Results 21 to 30 of about 59,509 (256)

Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel

Nature Communications, 2022
NaX is an atypical member of the voltage-gated sodium channel family that may contribute to Na+ homeostasis. Here, the authors describe the structural and functional attributes of the human NaX channel to reveal new insights into its physiology.
Cameron L. Noland, Han Chow Chua, Marc Kschonsak, Stephanie Andrea Heusser, Nina Braun, Timothy Chang, Christine Tam, Jia Tang, Christopher P. Arthur, Claudio Ciferri, Stephan Alexander Pless, Jian Payandeh   +11 more
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Voltage‐gated Sodium Channels in Epilepsy [PDF]

Epilepsia, 2002
Summary: Animal experiments, and particularly functional investigations on human chronically epileptic tissue as well as genetic studies in epilepsy patients and their families strongly suggest that some forms of epilepsy may share a pathogenetic mechanism: an alteration of voltage‐gated sodium channels. This review summarizes recent data on changes of
openaire   +2 more sources

Structural Advances in Voltage-Gated Sodium Channels

Frontiers in Pharmacology, 2022
Voltage-gated sodium (NaV) channels are responsible for the rapid rising-phase of action potentials in excitable cells. Over 1,000 mutations in NaV channels are associated with human diseases including epilepsy, periodic paralysis, arrhythmias and pain disorders.
Daohua Jiang, Daohua Jiang, Jiangtao Zhang, Jiangtao Zhang, Zhanyi Xia, Zhanyi Xia   +5 more
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Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. [PDF]

PLoS Genetics, 2008
In many mammalian neurons, dense clusters of ion channels at the axonal initial segment and nodes of Ranvier underlie action potential generation and rapid conduction.
Alexis S Hill, Atsuo Nishino, Koichi Nakajo, Giuxin Zhang, Jaime R Fineman, Michael E Selzer, Yasushi Okamura, Edward C Cooper   +7 more
doaj   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease

Reviews in Cardiovascular Medicine
Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI.
Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang   +5 more
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Functional correlates of clinical phenotype and severity in recurrent SCN2A variants

Communications Biology, 2022
A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki, Katherine B. Howell, Jacqueline Heighway, Nelson Olivier, Jill Rodda, Isabella Overmars, Danique R. M. Vlaskamp, Tyson L. Ware, Simone Ardern-Holmes, Gaetan Lesca, Michael Alber, Pierangelo Veggiotti, Ingrid E. Scheffer, Samuel F. Berkovic, Markus Wolff, Steven Petrou   +15 more
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Voltage-gated sodium channels in cancers

Biomarker Research
AbstractVoltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate classic action potentials, showing potential as a promising pharmacological target for cancer ...
Hengrui Liu, Jieling Weng, Christopher L.-H. Huang, Antony P. Jackson   +3 more
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Voltage-gated sodium channels dysfunction in depression: the hypothesis

Psychiatry and Behavioral Sciences, 2016
Voltage-gated sodium (Na+) channels (VGSCs) are responsible for action potential initiation and propagation in most electrically excitable cells which are implicated in a wide range physiological functions including neuronal signalling, muscle ...
Osman Ozdemir
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A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.

PLoS Computational Biology, 2007
The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission. The currently most accurate method for determining ion channel kinetic mechanisms is single-channel recording and analysis.
Meron Gurkiewicz, Alon Korngreen
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Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging

Scientific Reports, 2023
Voltage-gated sodium channels shape action potentials that propagate signals along cells. When the membrane potential reaches a certain threshold, the channels open and allow sodium ions to flow through the membrane depolarizing it, followed by the ...
Shih-Ying Scott Chang, Patricia M. Dijkman, Simon A. Wiessing, Misha Kudryashev   +3 more
doaj   +1 more source