Results 71 to 80 of about 59,509 (256)

Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review

Journal of Cannabis Research
Background Voltage-gated sodium channels regulate dorsal root ganglion excitability and are critical for nociceptive transmission. Cannabidiol (CBD) and related phytocannabinoids have been proposed to modulate these channels, offering potential non ...
Samuel Gonçalves Castro, Sarah Eduarda Silva, Julio Cesar Moreira Brito, Alessandra Matavel   +3 more
doaj   +1 more source

Whole-exome sequencing in obstructive coronary artery disease identifies rare and novel variants in cardiac arrhythmia and pulmonary arterial hypertension–associated genes

Biomolecules & Biomedicine
Coronary artery disease (CAD) represents a complex interplay of genetic, environmental, and lifestyle factors. In this study, we utilized whole-exome sequencing (WES) on 28 patients with obstructive CAD to identify rare variants that may influence ...
Mohammad Fahad Ullah, Rashid Mir, Jamsheed Javid, Imadeldin Elfaki, Faisal H. Altemani, Jameel Barnawi, Naseh A. Algehainy, Mohammed M. Jalal, Malik A. Altayar, Salem Owaid Albalawi, Syed Khalid Mustafa, Aadil Yousif, Eram Husain, Faris J. Tayeb, Faisel M. AbuDuhier   +14 more
doaj   +1 more source

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

Nature Communications, 2016
Gating of the central pore in voltage-dependent ion channels is mediated by changes in membrane potential. Here, the authors use substituted cysteine accessibility and metal cross-bridging to identify gate residues that form a physical occlusion when ...
Kevin Oelstrom, Baron Chanda
doaj   +1 more source

Boolean Logic‐Based Control Over Recombinant Protein Biomaterial Degradability and Therapeutic Delivery

Advanced Materials, EarlyView.
Fully recombinant protein‐based biomaterials execute complex Boolean logic for user‐programmable material degradation and concomitant therapeutic cargo release. Biologics, such as growth factors, can be incorporated within the crosslinkers as “drugamers”, while encapsulated cells can be released according to nested YES/OR/AND‐type logical operations ...
Murial L. Ross, Ryan Gharios, Shivani Kottantharayil, Cole A. DeForest   +3 more
wiley   +1 more source

Skeletal Muscle Na+ Channel Disorders

Frontiers in Pharmacology, 2011
Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Nav1.4.
Dina eSimkin, Saïd eBendahhou
doaj   +1 more source

Inherited disorders of voltage-gated sodium channels [PDF]

Journal of Clinical Investigation, 2005
A variety of inherited human disorders affecting skeletal muscle contraction, heart rhythm, and nervous system function have been traced to mutations in genes encoding voltage-gated sodium channels. Clinical severity among these conditions ranges from mild or even latent disease to life-threatening or incapacitating conditions.
openaire   +2 more sources

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

Sodium channels and mammalian sensory mechanotransduction

Molecular Pain, 2012
Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin, Rugiero Francois, Kiesewetter Hannes, Hatch Rachel, Hummler Edith, Nassar Mohammed A, Wang Fan, Wood John N   +7 more
doaj   +1 more source

Voltage-gated sodium channels in the mammalian heart

Global Cardiology Science and Practice, 2014
Mammalian species express nine functional voltage-gated Na(+) channels. Three of them, the cardiac-specific isoform Nav1.5 and the neuronal isoforms Nav1.8 and Nav1.9, are relatively resistant to the neurotoxin tetrodotoxin (TTX; IC50 ≥ 1 μM). The other six isoforms are highly sensitive to TTX with IC50 values in the nanomolar range. These isoforms are
Zimmer, Thomas, Haufe, Volker, Blechschmidt, Steve   +2 more
openaire   +2 more sources