Results 191 to 200 of about 110,652 (333)

Alternative splicing in voltage-gated sodium channels: mechanisms, regulatory networks and therapeutic implications. [PDF]

Ann Med
Qiu J, Wu P, Zhang Y, Li Y, Xia C, Peng S, Sun J.   +6 more
europepmc   +1 more source

Action potential conduction in the mouse and rat vagus nerve is dependent on multiple voltage-gated sodium channels (Na_V1s). [PDF]

J Neurophysiol, 2023
Nair SS, Pavelkova N, Murphy CM, Kollarik M, Taylor-Clark TE.   +4 more
europepmc   +1 more source

Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in theDrosophilaVoltage-Gated Sodium Channel Geneparalytic [PDF]

, 2016
Garrett A. Kaas, Junko Kasuya, Patrick Lansdon, Atsushi Ueda, Atulya Iyengar, Chun‐Fang Wu, Toshihiro Kitamoto   +6 more
openalex   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Block of Voltage-Gated Sodium Channels by Aripiprazole in a State-Dependent Manner. [PDF]

Int J Mol Sci, 2022
Föhr KJ, Rapp M, Fauler M, Zimmer T, Jungwirth B, Messerer DAC.   +5 more
europepmc   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment. [PDF]

J Comp Neurol
Lysakowski A, Govindaraju AC, Price SD, Gaboyard-Niay S, Calin-Jageman I, Chidavaenzi RL, Eatock RA, Raphael RM, Goldberg JM.   +8 more
europepmc   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Molecular determinants of prokaryotic voltage‐gated sodium channels for recognition of local anesthetics [PDF]

, 2016
Takushi Shimomura, Katsumasa Irie, Yoshinori Fujiyoshi   +2 more
openalex   +1 more source

Preorganized Electric Fields in Voltage-Gated Sodium Channels. [PDF]

Chembiochem
Zheng Y, Chen T, Vaissier Welborn V.
europepmc   +1 more source