Results 211 to 220 of about 110,652 (333)

Interaction between Fast and Ultra-slow Inactivation in the Voltage-gated Sodium Channel [PDF]

, 2002
Karlheinz Hilber, Walter Sandtner, Oliver Kudlacek, Blanca Schreiner, Ian W. Glaaser, Wolfgang Schütz, Harry A. Fozzard, Samuel C. Dudley, Hannes Todt   +8 more
openalex   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Pharmacological targeting and characterization of Voltage-Gated Sodium Channels (VGSCs) expressed in the high-grade glioma microenvironment. [PDF]

BMC Cancer
Fletcher EV, Shard C, Boyle Y, Milligan CJ, Cross RSN, Jones AC, Francis A, Dewdney B, Barker M, Rezaeiravesh S, Ng ZY, Yeow Y, Kuznetsova I, Jones ME, Ormsby RJ, Poonnoose SI, Patil A, Valvi S, Jenkins MR, Forrest ARR, Petrou S, Gomez GA, Johns TG.   +22 more
europepmc   +1 more source

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons.

Cell, 2023
Libé-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Konstantoulea K, Nyitrai H, De Vleeschouwer M, Vennekens KM, Vidal N, Bird TW, Soto DC, Jaspers T, Dewilde M, Dennis MY, Rousseau F, Comoletti D, Schymkowitz J, Theys T, de Wit J, Vanderhaeghen P.   +24 more
europepmc   +1 more source

Non-psychotropic phytocannabinoid interactions with voltage-gated sodium channels: An update on cannabidiol and cannabigerol. [PDF]

Front Physiol, 2022
Ghovanloo MR, Dib-Hajj SD, Goodchild SJ, Ruben PC, Waxman SG.   +4 more
europepmc   +1 more source

Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole [PDF]

, 2012
Jean‐François Desaphy, Teresa Costanza, Roberta Carbonara, Maria Maddalena Cavalluzzi, Carlo Franchini, Giovanni Lentini, Diana Conte Camerino   +6 more
openalex   +1 more source

Voltage-Gated Sodium Channels [PDF]

, 2016
openaire   +2 more sources

Laparoscopic Delivery of a MnO2‐P‐ICG Patch for Photodynamic Therapy and NK Cell‐Driven Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin, Haoqi Pan, Ke Wu, Junjie Nan, Jinyao Dai, Yushun Chang, Hao Shen, Qingxuan Ye, Haowen Lu, Yuxuan Shen, Boqiang Liu, Ming Wu, Jicheng Yu, Xiujun Cai, Dong Cen   +14 more
wiley   +1 more source

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease. [PDF]

Rev Cardiovasc Med
Zhang XL, Wei TP, Yang F, Liu HH, Qian LL, Wang RX.   +5 more
europepmc   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source