Results 91 to 100 of about 418,282 (300)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation

Frontiers in Pharmacology, 2020
The hERG (human-ether-à-go-go-related gene) channel underlies the rapid delayed rectifier current, Ikr, in the heart, which is essential for normal cardiac electrical activity and rhythm.
Yu Patrick Shi, Samrat Thouta, Thomas W. Claydon   +2 more
doaj   +1 more source

Pixel design and evaluation in CMOS image sensor technology [PDF]

, 2009
A chip designed in a 0.18 μm CMOS Image Sensor Technology (CIS) is presented which incorporates different pixel design alternatives for Active Pixel Sensor (APS).
Liñán Cembrano, Gustavo, Roca Moreno, Elisenda, Vargas Sierra, Sonia   +2 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Compensated Current Injection circuit, theory and applications [PDF]

, 2002
This paper presents a detailed description, analysis and example of practical application of a wide frequency band voltage-to-current converter. The converter is characterized by a combination of positive and negative feedback loops.
Giorgio Fontana, Jafry Y., Lafargue L., Touboul P.   +3 more
core   +2 more sources

Voltage-Dependent Gating in a “Voltage Sensor-Less” Ion Channel

PLoS Biology, 2010
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity. We have identified a remarkable point mutation that confers significant voltage dependence to Kir6.2, a ligand-gated channel that lacks ...
Kurata, Harley T, Rapedius, Markus, Kleinman, Marc J, Baukrowitz, Thomas, Nichols, Colin G   +4 more
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9

Toxins, 2012
Human voltage-activated sodium (Nav) channels are adept at rapidly transmitting electrical signals across long distances in various excitable tissues. As such, they are amongst the most widely targeted ion channels by drugs and animal toxins. Of the nine
John Gilchrist, Frank Bosmans
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Ultra-High Voltage NV Center Magnetic Sensing System Based on Power over Fiber

Photonics
Aiming to address the insulation and power supply challenges faced by electrical measurement in ultra-high voltage (UHV) environments, this study proposes and implements a nitrogen-vacancy (NV) center magnetic sensing system based on Power over Fiber ...
Linfeng Zhan, Chenggang Guan, Chaoqiang Dong, Xuelong Fan, Qingtao Guo, Weiqi Wang, Yifan Xiao, Xuan Chen, Junchang Huang, Xueyou Zhang, Wenxin Jiang, Jiaoli Gong   +11 more
doaj   +1 more source