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Von Willebrand disease diagnosis: from complexity to simplicity [PDF]
Research and Practice in Thrombosis and HaemostasisVon Willebrand disease (VWD) is a complex disorder in terms of both its pathophysiology and treatment. The broad recognition and treatment of patients with VWD is often hindered by the complicated diagnostic process.
Quentin Van Thillo, Cédric Hermans
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Genetic variants in VWF exon 26 and their implications for type 1 Von Willebrand disease in a Saudi Arabian population [PDF]
Open Life SciencesVon Willebrand disease (VWD) is one of the most common bleeding disorders, stemming from irregularities in the Von Willebrand factor (VWF). Globally, type 1 VWD (VWD1) is the most prevalent form, characterized by decreased levels of VWF in the blood ...
Alzahrani Faisal M. +8 more
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Rictor maintains endothelial integrity under shear stress
Frontiers in Cell and Developmental Biology, 2022 Background: Endothelial injury induced by low shear stress (LSS) is an initiating factor in the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, and thrombotic diseases.
Hui Li +9 more
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Frontiers in Pediatrics, 2022 BackgroundAcquired von Willebrand syndrome (AVWS) is a less common bleeding disorder, primarily manifested as mild to moderate mucocutaneous bleeding and laboratory tests are similar to hereditary von Willebrand disease (VWD).
Songmi Wang +6 more
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von Willebrand's disease [PDF]
European Journal of Haematology, 1975 The common inheritable hemorrhagic disorder, von Willebrand's disease, has been known for only about 50 yr. During these years it has been well established that the cause of the disease is a deficiency of a plasma protein with remarkable biological properties. Future research should focus on details of the molecular structure of this protein.
L, Holmberg, I M, Nilsson
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Pseudotumor of the Maxillary Sinus in a Child with Von Willebrand Disease [PDF]
Iranian Journal of Otorhinolaryngology, 2022 Introduction:Mandibular pseudotumors, also known as blood cysts, are rare complications which occur more frequently in patients with an associated bleeding disorder such as hemophilia.Case Report: We present a case of a 2-year and 6-month-old patient ...
Martha Gutierrez Perez +4 more
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Неврология, нейропсихиатрия, психосоматика, 2021 Endothelial dysfunction is a universal pathological mechanism underlying or contributing to the development/progression of many diseases, including cerebrovascular disease and multiple sclerosis.
I. A. Koltsov +5 more
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Pediatrics In Review, 2014 Von Willebrand disease (VWD) is an inherited defect of blood coagulation that may cause excessive bleeding.
Stacy, Cooper, Clifford, Takemoto
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Genetics in Medicine, 2011 von Willebrand disease is a common inherited bleeding disorder characterized by excessive mucocutaneous bleeding. Characteristic bleeding symptoms include epistaxis, easy bruising, oral cavity bleeding, menorrhagia, bleeding after dental extraction, surgery, and/or childbirth, and in severe cases, bleeding into joints and soft tissues.
Paula D, James, Anne C, Goodeve
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Mechanical Forces Impacting Cleavage of Von Willebrand Factor in Laminar and Turbulent Blood Flow
Fluids, 2021 Von Willebrand factor (VWF) is a large multimeric hemostatic protein. VWF is critical in arresting platelets in regions of high shear stress found in blood circulation. Excessive cleavage of VWF that leads to reduced VWF multimer size in plasma can cause
Alireza Sharifi, David Bark
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