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von Willebrand Disease

Medicine, 1997
Considerable progress has been made in characterizing the specific molecular defects responsible for the heterogeneous disorder known as von Willebrand disease (VWD). A large number of molecular defects have been identified and precise characterization may now be possible in the majority of type 2A, type 2B, type 2N, and potentially also type 3 VWD ...
William C. Nichols, David Ginsburg
openalex   +3 more sources

Intraindividual variability of von Willebrand factor and the need for repeated testing [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Diagnosing von Willebrand disease (VWD) is complicated by intraindividual variation of von Willebrand factor (VWF). Current guidelines define VWD as VWF antigen (VWF:Ag) or VWF activity of
Malene Helligsø Kirkeby, Johanne Andersen Højbjerg, Anders Mønsted Abildgaard, Julie Brogaard Larsen   +3 more
doaj   +2 more sources

Prevalence of iron deficiency in patients with mild to moderate bleeding disorders and bleeding disorder of unknown cause [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Iron deficiency (ID) and ID anemia (IDA) are often caused by chronic bleeding, especially heavy menstrual bleeding, and thus may occur at a high frequency in patients with mild to moderate bleeding disorders (MBDs).
Tim Dreier, Dino Mehic, Justin Oosterlee, Jasmin Rast, Alexandra Kaider, Helmuth Haslacher, Cihan Ay, Ingrid Pabinger, Johanna Gebhart   +8 more
doaj   +2 more sources

Treatment of Von Willebrand Disease [PDF]

Thrombosis and Haemostasis, 2001
SummaryIn von Willebrand disease, there are two main options for the treatment of spontaneous bleeding episodes and for bleeding prophylaxis: desmopressin and transfusional therapy with plasma products. Desmopressin is the treatment of choice for most patients with type 1, who account for approximately 70 to 80 per cent of all cases with the disease ...
P M Mannucci
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Acquired von Willebrand syndrome in young children with congenital heart defects: focus on patent ductus arteriosus and ventricular septal defect [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder due to a deficiency of von Willebrand factor (VWF). High shear stress causes stretching and rupture of VWF multimers, leading to functional loss and increased proteolysis ...
Oksana Trębacz, Katarzyna Szafarz, Joanna Zdziarska, Jacek Podlewski, Piotr Weryński, Wojciech Tarała, Teresa Iwaniec   +6 more
doaj   +2 more sources

Oral post-surgical complications in patients with hemophilia and von Willebrand disease [PDF]

Hematology, Transfusion and Cell Therapy
Objective: To determine the prevalence of post-surgical complications in patients with hemophilia and von Willebrand disease. Methods: A prospective, cross-sectional study with descriptive and exploratory data analysis was conducted at the outpatient ...
Luisa Catarina Porfirio de Sousa, Elanne Cristina Garcia da Costa Félix, Wagner Hespanhol, Raquel dos Santos Pinheiro   +3 more
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Case report: A case of acquired von Willebrand syndrome as onset clinical presentation of systemic lupus erythematosus manifested as epistaxis and pulmonary hemorrhage

Frontiers in Pediatrics, 2022
BackgroundAcquired von Willebrand syndrome (AVWS) is a less common bleeding disorder, primarily manifested as mild to moderate mucocutaneous bleeding and laboratory tests are similar to hereditary von Willebrand disease (VWD).
Songmi Wang, Qun Hu, Yaxian Chen, Xiufen Hu, Ning Tang, Ai Zhang, Aiguo Liu   +6 more
doaj   +1 more source

Rictor maintains endothelial integrity under shear stress

Frontiers in Cell and Developmental Biology, 2022
Background: Endothelial injury induced by low shear stress (LSS) is an initiating factor in the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, and thrombotic diseases.
Hui Li, Wen-Ying Zhou, Yi-Xian Liu, Yi-Yuan Xia, Chun-Lei Xia, Dao-Rong Pan, Zheng Li, Yi Shi, Shao-Liang Chen, Jun-Xia Zhang   +9 more
doaj   +1 more source

Pseudotumor of the Maxillary Sinus in a Child with Von Willebrand Disease [PDF]

Iranian Journal of Otorhinolaryngology, 2022
Introduction:Mandibular pseudotumors, also known as blood cysts, are rare complications which occur more frequently in patients with an associated bleeding disorder such as hemophilia.Case Report: We present a case of a 2-year and 6-month-old patient ...
Martha Gutierrez Perez, Juan Lugo Machado, Natalia Barreto Nino, Luis Paredes Bastos, David Acevedo Contreras   +4 more
doaj   +1 more source

von Willebrand's disease [PDF]

European Journal of Haematology, 1975
The common inheritable hemorrhagic disorder, von Willebrand's disease, has been known for only about 50 yr. During these years it has been well established that the cause of the disease is a deficiency of a plasma protein with remarkable biological properties. Future research should focus on details of the molecular structure of this protein.
Lars Holmberg, Inga Marie Nilsson
openaire   +5 more sources