Results 31 to 40 of about 192,512 (365)

Comprehensive Analyses of Coagulation Parameters in Patients with Vascular Anomalies

Biomolecules, 2022
Background: Vascular anomalies comprise a diverse group of rare diseases with altered blood flow and are often associated with coagulation disorders. The most common example is a localized intravascular coagulopathy in venous malformations leading to ...
Friedrich G. Kapp, Cedric Schneider, Annegret Holm, Hannah Glonnegger, Charlotte M. Niemeyer, Jochen Rößler, Barbara Zieger   +6 more
doaj   +1 more source

von Willebrand factor propeptide: biology and clinical utility.

Blood, 2015
von Willebrand factor (VWF) is a large multimeric glycoprotein that mediates the attachment of platelets to damaged endothelium and also serves as the carrier protein for coagulation factor VIII (FVIII), protecting it from proteolytic degradation ...
S. Haberichter
semanticscholar   +1 more source

Predicting Shape Development: a Riemannian Method [PDF]

Shape in Medical Imaging, pp. 211-222, 2023, 2022
Predicting the future development of an anatomical shape from a single baseline observation is a challenging task. But it can be essential for clinical decision-making. Research has shown that it should be tackled in curved shape spaces, as (e.g., disease-related) shape changes frequently expose nonlinear characteristics.
arxiv   +1 more source

ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis [PDF]

, 2005
Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family are known to influence development, angiogenesis, coagulation and progression of arthritis.
Jones, GC, Riley, GP
core   +2 more sources

Von Willebrand Factor, Angiodysplasia and Angiogenesis

Mediterranean Journal of Hematology and Infectious Diseases, 2013
The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes.
A. Randi, M. Laffan, R. Starke
semanticscholar   +1 more source

Beyond Barker: Infant Mortality at Birth and Ischaemic Heart Disease in Older Age [PDF]

, 2022
Adverse conditions in early life can have consequential impacts on individuals' health in older age. In one of the first papers on this topic, Barker and Osmond 1986 show a strong positive relationship between infant mortality rates in the 1920s and ischaemic heart disease in the 1970s.
arxiv   +1 more source

Shear-induced acquired von Willebrand syndrome: an accomplice of bleeding events in adults on extracorporeal membrane oxygenation support

Frontiers in Cardiovascular Medicine, 2023
Extracorporeal membrane oxygenation (ECMO) is an increasingly acceptable life-saving mechanical assistance system that provides cardiac and/or respiratory support for several reversible or treatable diseases.
Haiwang Wang, Haiwang Wang, Haiwang Wang, Duo Li, Duo Li, Duo Li, Yuansen Chen, Yuansen Chen, Yuansen Chen, Ziquan Liu, Ziquan Liu, Ziquan Liu, Yanqing Liu, Yanqing Liu, Yanqing Liu, Xiangyan Meng, Xiangyan Meng, Xiangyan Meng, Haojun Fan, Haojun Fan, Haojun Fan, Shike Hou, Shike Hou, Shike Hou   +23 more
doaj   +1 more source

Dental management considerations for the patient with an acquired coagulopathy. Part 1: Coagulopathies from systemic disease [PDF]

, 2003
Current teaching suggests that many patients are at risk for prolonged bleeding during and following invasive dental procedures, due to an acquired coagulopathy from systemic disease and/or from medications.
A Barber, AB Lumb, AD Kaye, AGG Turpie, AH Friedlander, AI Schafer, AM Ziffer, AS Gewirtz, AT Mailloux, BS Coller, C Kearon, CA Petruff, CH Mielke Jr., CL Norred, D Blinder, D Deykin, DB Petitti, DF Pawlak, DM Eisenberg, EM Hylek, F Catella-Lawson, FE Silverstein, G Palareti, G Russo, H Bagheri, H Ogiuchi, IW Scopp, J Gibson, J Harenberg, J Hirsh, J Hirsh, J Hirsh, J Leitch, J Marshall, JA Oates, JA Ware, JC O'Laughlin, JH Campbell, JN George, JN Saour, JR Vane, K Webster, L Bodner, L Mengle-Gaw, LC Tsen, LS Simon, M Akbarian, M Hurlen, M Levine, MH Eckman, MH Eckman, MJ Steinburg, MJ Troulis, MJ Wahl, MJ Wahl, MK Ang-Lee, MMW Koopman, N May, OR Beirne, P B Lockhart, P Devani, PC Amrein, PJ Sharis, R Benoliel, R De Caterina, R Hull, R Mulligan, R Mulligan, R Stern, RA Seymour, RE Alexander, RH White, RI Shorr, RT Weibert, S Cronberg, S Goldman, S H Pond, S Lippert, SC Cannegieter, SD Fihn, SE Lind, SE Lind, SI Rapaport, SJ Behrman, SR Cox, SS De Rossi, T Bandrowsky, TP Rooney, VA Ferraris, WR Bartle, WW Herman   +90 more
core   +1 more source

Changes of von Willebrand Factor during Pregnancy in Women with and without von Willebrand Disease

Mediterranean Journal of Hematology and Infectious Diseases, 2013
Delivery in von Willebrand disease (VWD) represents a significant hemostatic challenge because of the variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF.
G. Castaman
semanticscholar   +1 more source

Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis [PDF]

J. Thromb. Haemost. 2009 (7), 2096-2105, 2009
To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations.
arxiv   +1 more source