Results 141 to 150 of about 212,775 (379)

Ibrutinib treatment affects collagen and von Willebrand factor-dependent platelet functions.

open access: yesBlood, 2014
The oral Bruton's tyrosine kinase inhibitor, ibrutinib, has recently demonstrated high efficiency in patients with relapsed B-cell malignancies. Occurrence of bleeding events has been reported in a subgroup of ibrutinib-treated patients.
M. Levade   +10 more
semanticscholar   +1 more source

Epinephrine and dDAVP administration in patients with congenital nephrogenic diabetes insipidus Evidence for a pre-cyclic AMP V2 receptor defective mechanism [PDF]

open access: yes
Epinephrine and dDAVP administration in patients with congenital nephrogenic diabetes insipidus. Evidence for a pre-cyclic AMP V2 receptor defective mechanism. We recently showed that the administration of the antidiuretic V2 specific agonist, l-desamino[
Arthus, Marie-Françoise   +7 more
core   +1 more source

Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, life‐threatening thrombotic microangiopathy caused by a severe inherited deficiency of ADAMTS13, a von Willebrand factor (VWF) cleaving enzyme. Inadequate clinical endpoint data often make it challenging to statistically power clinical trials in ultra‐rare diseases ...
Cameron McBride   +8 more
wiley   +1 more source

Laminar Flow Alters EV Composition in HUVECs: A Study of Culture Medium Optimization and Molecular Profiling of Vesicle Cargo

open access: yesSmall Methods, EarlyView.
Schematic illustration of the current study. A) Multiple cell culture media are used for HUVEC cultures under both static and flow conditions. Cells are analyzed for morphology, endothelial markers, and gene expression. B) EVs are isolated from static and flow HUVEC cultures, and investigated for particle characterization, transcriptome and proteome ...
Arefeh Kardani   +13 more
wiley   +1 more source

Closing the gap – detection of clinically relevant von Willebrand disease in emergency settings through an improved algorithm based on rotational Thromboelastometry

open access: yesBMC Anesthesiology, 2019
Background Hemorrhage and blood loss are still among the main causes of preventable death. Global hemostatic assays are useful point-of-care test (POCT) devices to rapidly detect cumulative effects of plasma factors and platelets on coagulation ...
H.-G. Topf   +5 more
doaj   +1 more source

Menstrual suppression to decrease intrauterine device expulsion in adolescents with inherited bleeding disorders

open access: yes
International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 421-423, April 2025.
Peter H. Cygan   +3 more
wiley   +1 more source

Plasma POSTN Derived From Bile Proteome Is a Promising Biomarker for Cholangiocarcinoma With Efficacy Comparable and Complementary to CA19.9

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n 
Lichieh Julie Chu   +6 more
wiley   +1 more source

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