Results 51 to 60 of about 328,885 (284)
Clearance of von Willebrand factor [PDF]
Journal of Thrombosis and Haemostasis, 2013 Quantitative deficiencies in von Willebrand factor (VWF) are associated with abnormal hemostasis that can manifest in bleeding or thrombotic complications. Consequently, many studies have endeavored to elucidate the mechanisms underlying the regulation of VWF plasma levels. This review focuses on the role of VWF clearance pathways.
Caterina Casari +4 more
openaire +3 more sources
Ibrutinib effect in acquired von Willebrand syndrome secondary to Waldenström macroglobulinemia
Therapeutic Advances in Hematology, 2021 The pathological increase of clonal IgM in Waldenström macroglobulinemia can be associated with acquired von Willebrand syndrome and can be a major risk of bleeding symptoms in this subgroup of patients with Waldenström macroglobulinemia.
María Poza +6 more
doaj +1 more source
Zebrafish von Willebrand factor [PDF]
Blood Cells, Molecules, and Diseases, 2010 von Willebrand factor (vWF) is a large protein involved in primary hemostasis. A dysfunction in this protein or an insufficient production of the protein leads to improper platelet adhesion/aggregation, resulting in a bleeding phenotype known as von Willebrand disease (vWD).
Vrinda Kulkarni +4 more
openaire +3 more sources
Научно-практическая ревматология, 2004 Objective. To determine the importance of von Willebrand factor antigen as marker of endotheliae damage at the patients with systemic lupus erythematosus (SLE). Material and methods. 30 women from authentic SLE by criteria ACR, in the age of 20-45 years,
M E Zapryagaeva, E S Mach, A A Baranov
doaj +1 more source
Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
Nature Communications, 2017 Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis.
Hongxia Fu +5 more
semanticscholar +1 more source
Medicina, 2023 Acquired von Willebrand factor deficiency has been described in patients with aortic valve stenosis due to high shear forces developed during passage through the narrowed valve orifice, which determines structural changes in this molecule.
Andrei Emanuel Grigorescu +3 more
doaj +1 more source
Shear-induced unfolding and enzymatic cleavage of full-length VWF multimers [PDF]
, 2015 Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within the mechanosensitive A2 domain, which is believed to open under shear flow.
arxiv +1 more source
Von Willebrand factor and angiogenesis: basic and applied issues
Journal of Thrombosis and Haemostasis, 2017 The recent discovery that von Willebrand factor (VWF) regulates blood vessel formation has opened a novel perspective on the function of this complex protein.
A. Randi, M. Laffan
semanticscholar +1 more source
Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease
Case Reports in Hematology, 2015 von Willebrand disease type 3 (VWD3) is a rare but the most severe form of von Willebrand disease; it is due to almost complete lack of von Willebrand factor activity (VWF:RCo).
Victoria Campbell +3 more
doaj +1 more source
[Cost-minimization analysis of replacement therapy in the treatment of von Willebrand disease]
Farmeconomia: Health Economics and Therapeutic Pathways, 2016 BACKGROUND: Replacement therapy with von Willebrand factor (VWF)/factor VIII (FVIII) concentrates represents an effective approach for patients with von Willebrand disease (VWD) who are unresponsive to desmopressin.
Giancarlo Castaman
doaj +1 more source