Plasma concentration of voriconazole under concomitant use of nirmatrelvir/ritonavir in patients with COVID-19: a multicenter retrospective study. [PDF]
Front PharmacolBackgroundThe concomitant use of nirmatrelvir/ritonavir and voriconazole is generally contraindicated in clinical practice because of drug‒drug interactions (DDIs).
Shi H, Zhang X, Kong Q, Yu L, Yu Z.
europepmc +2 more sources
The pharmacokinetics of voriconazole [PDF]
British Journal of Clinical Pharmacology, 2003 Voriconazole (Vfend® Pfizer Global Research and Development, Sandwich, Kent, UK) is a broad-spectrum antifungal triazole that is structurally related to fluconazole. As with all triazole antifungal agents, voriconazole works principally by inhibition of cytochrome P450 14-α-demethylase (P450 14DM) [1, 2].
A. E. Johnston
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Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case-control study. [PDF]
Front PharmacolIntroductionVoriconazole is widely used to prevent and treat invasive aspergillosis. However, its use is restricted by adverse effects, including acute liver injury (ALI).
Ren J +8 more
europepmc +2 more sources
Metamizole induces voriconazole metabolism and results in subtherapeutic voriconazole concentrations [PDF]
British Journal of Clinical PharmacologyAimsVoriconazole is extensively metabolized via cytochrome P450 (CYP) enzymes, predominantly CYP2C19 and CYP3A4. Drugs influencing the activity or expression of CYP enzymes can cause clinically relevant changes in the metabolism and voriconazole exposure. Metamizole is known to induce CYP3A4 and CYP2C19.
Simone D. Baan +3 more
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Prediction of the Impact of CYP2C19 Polymorphism on Drug-Drug Interaction between Voriconazole and Tacrolimus Using Physiologically-Based Pharmacokinetic Modelling [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2023 Voriconazole increases tacrolimus blood concentration significantly when coadministrated. The recommendation of reducing tacrolimus to 1/3 in voriconazole package insert seems not to be satisfactory in clinical practice.
Zhi-Ping Jin +8 more
doaj +1 more source
Journal of Fungi, 2022 Voriconazole is an antifungal drug used to treat invasive aspergillosis. Voriconazole exhibits nonlinear behavior and considerable individual variability in its pharmacokinetic profile.
Takeo Yasu +6 more
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Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid
Antibiotics, 2021 Background: Voriconazole is an antifungal drug used as one of the first-line treatments for invasive aspergillosis. This drug is extensively metabolized, predominantly via cytochrome P450 enzymes.
Ruth Van Daele +12 more
doaj +1 more source
An appraisal of antifungal impacts of nano-liposome containing voriconazole on voriconazole-resistant Aspergillus flavus isolates as a groundbreaking drug delivery system [PDF]
Nanomedicine Research Journal, 2020 Background: This study is an attempt to investigate the effect of nano-liposome containing voriconazole on voriconazole-resistant A. flavus strains on the one hand, and to consider the expression of cyp51A and MDR1genes, regarded as important genes ...
Parviz Hassanpour +7 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Voriconazole is a second-generation azole widely used for the prevention and treatment of fungal infection in leukemia patients. We report a case of 9-year-old girl with T-cell acute lymphoblastic leukemia who developed hallucinations and visual ...
Rujiang Zheng +5 more
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Therapeutic Advances in Drug Safety, 2022 Aims: The gene polymorphism of voriconazole metabolism–related liver enzyme is notable in East Asia population. It casts a significant influence on the rational use of voriconazole.
Kunlu Shen +7 more
doaj +1 more source