Results 51 to 60 of about 2,561,860 (169)

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Prevalence of Eight Viruses in Captive Amur Tigers (Panthera tigris altaica) From Harbin, China 中国哈尔滨市圈养东北虎8种病毒的流行

Wildlife Letters, EarlyView.
The Amur tiger, an endangered flagship species mainly found in the Russia Far East and Northeastern China, holds immense biological importance, and has been listed under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES).
Wei Xie, Luyao Wang, Mengna Chen, Qinjie Chang, Hongyu Jiang, Haitao Xu, Liu Dan, Xiang Li, Yulong Wang, Xiangwei Zeng, Bin Yang, Miaowei Wang, Yonggang Jiang, Hongliang Chai, Siyuan Yang, Yajun Wang   +15 more
wiley   +1 more source

Encephalomyocarditis virus abrogates the IFN-β signaling pathway via its structural protein VP2

, 2020
Type I interferon (IFN) - mediated antiviral responses are critical at modulating host-virus responses and indeed viruses have evolved strategies to antagonize this pathway.
Xu, Shujuan, Xie, Jingying, Bi, Yingjie, Idris, Adi, Feng, Ruofei, Zhang, Haixia, Han, Yumei, Li, Xiangrong, Bai, Jialin   +8 more
core   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Update on Viral Gene Therapy Clinical Trials for Retinal Diseases [PDF]

, 2022
In 2001, the first large animal was successfully treated with a gene therapy that restored its vision. Lancelot, the Briard dog that was treated, suffered from a human childhood blindness called Leber's congenital amaurosis type 2.
Cheng, Shun-Yun, Punzo, Claudio
core   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

First identification of canine parvovirus ‐2a/2b variant in unvaccinated domestic dogs with gastrointestinal signs in Türkiye

Veterinary Medicine and Science
Background Canine parvovirus type 2 (CPV‐2) is the most common enteric virus that infects canids. CPV is the causative agent of a contagious disease defined mostly by clinical gastrointestinal signs in dogs.
Hasbi Sait SALTIK, B Taylan KOÇ
doaj   +1 more source

Development of a Highly Efficient CRISPR/Cas9-Mediated Herpesvirus of Turkey-Based Vaccine against Novel Variant Infectious Bursal Disease Virus

Vaccines
Infectious bursal disease (IBD), caused by IBD virus (IBDV), is an extremely contagious immunosuppressive disease that causes major losses for the poultry industry worldwide.
Jun-Feng Zhang, Jong-Yeol Park, Sang-Won Kim, Yu-Ri Choi, Se-Yeoun Cha, Hyung-Kwan Jang, Bai Wei, Min Kang   +7 more
doaj   +1 more source

Molecular Detection of Parvovirus in Captive Siberian Tigers and Lions in Northeastern China From 2019 to 2021

Frontiers in Microbiology, 2022
The fact that wild felines are carriers of pernicious infectious viruses should be a major concern due to the potential cross-species transmission between the felines and human or domestic animals.
Shuping Huang, Xiang Li, Wei Xie, Lijun Guo, Dan You, Haitao Xu, Dan Liu, Yulong Wang, Zhijun Hou, Xiangwei Zeng, Siyuan Yang, Hongliang Chai, Yajun Wang   +12 more
doaj   +1 more source