A Subunit Vaccine Based on the VP2 Protein of Porcine Parvovirus 1 Induces a Strong Protective Effect in Pregnant Gilts [PDF]
Vaccines, 2023 Porcine parvovirus 1 (PPV1) is one of the most prevalent pathogens that can cause reproductive disorder in sows. The VP2 protein of PPV1 is the most important immunogenic protein that induces neutralizing antibodies and protective immunity.
Zhanye Ling +4 more
doaj +5 more sources
Neddylation of Enterovirus 71 VP2 Protein Reduces Its Stability and Restricts Viral Replication. [PDF]
J Virol, 2022 Neddylation is a ubiquitin-like posttranslational modification by conjugation of neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to specific proteins for regulation of their metabolism and biological activities.
Wang H +6 more
europepmc +6 more sources
Study of the immunogenicity of the VP2 protein of canine parvovirus produced using an improved Baculovirus expression system [PDF]
BMC Veterinary Research, 2020 Background Canine parvovirus (CPV) is now recognized as a serious threat to the dog breeding industry worldwide. Currently used CPV vaccines all have their specific drawbacks, prompting a search for alternative safe and effective vaccination strategies ...
Dao Chang +7 more
doaj +3 more sources
Identification and characterization of DNA aptamers specific to VP2 protein of canine parvovirus. [PDF]
Appl Microbiol Biotechnol, 2021 Canine parvovirus‐2 (CPV‐2) is ubiquitously distributed in dog population worldwide causing a severe and often fatal gastroenteritis. Owing to its highly contagious nature, rapid detection of CPV is crucial in effective control of the disease.
Singh M +10 more
europepmc +5 more sources
Characterization of a recombinant pseudorabies virus expressing porcine parvovirus VP2 protein and porcine IL-6 [PDF]
Virology Journal, 2020 Background Porcine parvovirus (PPV) and pseudorabies virus (PRV) are the important etiological agents of swine infectious diseases, resulting in huge economic losses to the Chinese swine industry. Interleukin-6 (IL-6) has the roles to support host immune
Hui-Hua Zheng +5 more
doaj +3 more sources
The Construction and Immunogenicity Analyses of a Recombinant Pseudorabies Virus with Senecavirus A VP2 Protein Coexpression. [PDF]
Microbiol Spectr, 2023 This study reports the construction of a recombinant PRV with SVA for the first time, and the resulting virus, rPRV-XJ-ΔTK/gE/gI-VP2, can induce high levels of neutralizing antibodies against both PRV and SVA in model mice.
Tao Q +10 more
europepmc +2 more sources
Development of an indirect ELISA using a novel linear epitope at the C-terminal region of the VP2 protein to specifically detect antibodies against Senecavirus A. [PDF]
Virol J, 2022 Background Senecavirus A (SVA) is a pathogen that has recently caused porcine idiopathic vesicular disease (PIVD). The clinical signs are similar to those of foot-and-mouth disease, porcine vesicular disease, and vesicular stomatitis.
Ma Z, Lv J, Zhang Z, Pan L.
europepmc +2 more sources
Feline Panleukopenia Virus With G299E Substitution in the VP2 Protein First Identified From a Captive Giant Panda in China. [PDF]
Front Cell Infect Microbiol, 2021 A feline panleukopenia virus (FPV), Giant panda/CD/2018, was isolated from a captive giant panda with mild diarrhea in 2018 in Chengdu, China, and further identified via indirect immunofluorescence assay (IFA), transmission electron microscopy (TEM ...
Yi S +16 more
europepmc +2 more sources
Identification of a conserved neutralizing epitope in Seneca Valley virus VP2 protein: new insight for epitope vaccine designment. [PDF]
Virol J, 2022 Background Seneca Valley virus (SVV) is a picornavirus that causes vesicular disease in swine. Clinical characteristics of the disease are similar to common viral diseases such as foot-and-mouth disease virus, porcine vesicular disease virus, and ...
Wen W +5 more
europepmc +2 more sources
The expression in plants of an engineered VP2 protein of Infectious Bursal Disease Virus induces formation of structurally heterogeneous particles that protect from a very virulent viral strain. [PDF]
PLoS One, 2021 Infectious Bursal Disease Virus (IBDV), the etiological agent of Gumboro disease, causes mortality and immunosuppression in chickens and major losses to poultry industry worldwide.
Marusic C +10 more
europepmc +2 more sources