Results 91 to 100 of about 20,520 (215)

APC receptor TLR22a-targeted antigen structure optimization enhances immune protection against grass carp reovirus II

Water Biology and Security
Grass carp (Ctenopharyngodon idella), a cornerstone of global freshwater aquaculture, face severe threats from grass carp reovirus II (GCRV-II), which causes massive mortality and economic losses.
Xue-Feng Wei, Zhu-Yang Deng, Fei-Fan Xu, Jia-Lun Tang, Le-Yang Chen, Bin Zhu   +5 more
doaj   +1 more source

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Yuan Li, Yingyu Wang, Bing Wang, Qin Ouyang, Weiqi Liu, Xiang Xu, Xu Zhang, Mingming Liu, Ruijuan Xiu   +8 more
wiley   +1 more source

Human rotavirus strains bearing VP4 gene P[6] allele recovered from asymptomatic or symptomatic infections share similar, if not identical, VP4 neutralization specificities

, 2003
A rotavirus VP4 gene P[6] allele has been documented in a number of countries to be characteristically associated with an endemic predominantly asymptomatic infection in neonates in maternity hospital nurseries.
Kapikian, Albert Z, Ross, Jerri, Hoshino, Yasutaka, Jones, Ronald W, Santos, Norma   +4 more
core   +1 more source

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

Analysis of proteolytic activity of viral VP4 protein.

, 2015
(A) 293T cells were transfected with the recombinant wild-type A-segment plasmid or the Ala or Asp substituted A-segment plasmids at sites pSer538, pTyr611 and pThr674 within VP4. At 24 h post-transfection, cell samples were harvested and electrophoresed
Boli Hu (750407), Lu Jia (295253), Jiyong Zhou (507690), Weiying Si (750408), Sanying Wang (507688), Xiaojuan Zheng (750409)   +5 more
core   +1 more source

Myristoylated rhinovirus VP4 protein activates TLR2-dependent pro-inflammatory gene expression.

, 2023
Asthma exacerbations are often caused by rhinovirus (RV). We and others have shown that Toll-like receptor 2 (TLR2), a membrane surface receptor that recognizes bacterial lipopeptides and lipoteichoic acid, is required and sufficient for RV-induced ...
Han, M, Ishikawa, T, Hershenson, MB, Goldsmith, AM, Jaipalli, S, Lei, J, Bentley, JK, Rajput, C, Hinde, J   +8 more
core   +1 more source

The Stronger Downregulation of in vitro and in vivo Innate Antiviral Responses by a Very Virulent Strain of Infectious Bursal Disease Virus (IBDV), Compared to a Classical Strain, Is Mediated, in Part, by the VP4 Protein

Frontiers in Cellular and Infection Microbiology, 2020
IBDV is economically important to the poultry industry. Very virulent (vv) strains cause higher mortality rates than other strains for reasons that remain poorly understood. In order to provide more information on IBDV disease outcome, groups of chickens
Katherine L. Dulwich, Katherine L. Dulwich, Amin Asfor, Alice Gray, Efstathios S. Giotis, Efstathios S. Giotis, Michael A. Skinner, Andrew J. Broadbent   +7 more
doaj   +1 more source

Optimization of the L/VP4 Substrate A.

, 2015
Alignment of SVV L/VP4 cleavage site (shown in italics) with L/VP4 junction sequences of closely related cardioviruses. The amino acids in each sequence that diverge from the consensus sequence (shown in bold) are highlighted. B. Conversion of modified L/
Linde A. Miles (754072), W. Nathaniel Brennen (754073), John T. Poirier (754074), Charles M. Rudin (163578)   +3 more
core   +1 more source

Molecular characterization of the outer capsid spike protein (VP4) gene from human group C rotavirus

, 1994
A cDNA copy of the third genomic RNA segment of a noncultivatable human group C rotavirus (Bristol) was generated by single primer amplification. Human group C rotavirus genome segment 3 contains 2283 bp and encodes the VP4 gene with an open reading ...
Fielding, P.A., Caul, E.O., Clarke, I.N., Lambden, P.R.   +3 more
core   +1 more source

First study conducted in Northern India that identifies group C rotavirus as the etiological agent of severe diarrhea in children in Delhi

Virology Journal, 2017
Background Group C Rotavirus (RVC) is an enteric pathogen responsible for acute gastroenteritis in children and adults globally. At present there are no surveillance studies on group C Rotaviruses in India and therefore their prevalence in India remains ...
Vasundhara Razdan Tiku, Baoming Jiang, Praveen Kumar, Satender Aneja, Arvind Bagga, Maharaj Kishen Bhan, Pratima Ray   +6 more
doaj   +1 more source