Results 31 to 40 of about 20,520 (215)

Structures of Rotavirus Reassortants Demonstrate Correlation of Altered Conformation of the VP4 Spike and Expression of Unexpected VP4-Associated Phenotypes [PDF]

Journal of Virology, 2003
ABSTRACT Numerous prior studies have indicated that viable rotavirus reassortants containing structural proteins of heterologous parental origin may express unexpected phenotypes, such as changes in infectivity and immunogenicity. To provide a structural basis for alterations in phenotypic expression, a three-dimensional structural analysis ...
Joseph B, Pesavento, Angela M, Billingsley, Ed J, Roberts, Robert F, Ramig, B V Venkataram, Prasad   +4 more
openaire   +2 more sources

Membrane Interactions and Uncoating of Aichi Virus, a Picornavirus That Lacks a VP4 [PDF]

Journal of Virology, 2022
To initiate infection, viruses must enter a host cell and deliver their genome into the appropriate location. The picornavirus family of small nonenveloped RNA viruses includes significant human and animal pathogens and is also a model to understand the process of cell entry.
James T. Kelly, Jessica Swanson, Joseph Newman, Elisabetta Groppelli, Nicola J. Stonehouse, Tobias J. Tuthill   +5 more
openaire   +4 more sources

An Engineered Maturation Cleavage Provides a Recombinant Mimic of Foot-and-Mouth Disease Virus Capsid Assembly-Disassembly

Life, 2021
Picornavirus capsids are assembled from 60 copies of a capsid precursor via a pentameric assembly intermediate or ‘pentamer’. Upon completion of virion assembly, a maturation event induces a final cleavage of the capsid precursor to create the capsid ...
Joseph Newman, David J. Rowlands, Tobias J. Tuthill   +2 more
doaj   +1 more source

Metabolic and performance responses of male runners wearing 3 types of footwear: Nike Vaporfly 4%, Saucony Endorphin racing flats, and their own shoes

Journal of Sport and Health Science, 2022
Purpose: We compared running economy (RE) and 3-km time-trial (TT) variables of runners wearing Nike Vaporfly 4% (VP4), Saucony Endorphin lightweight racing flats (FLAT), and their habitual running (OWN) footwear.
Kim Hébert-Losier, Steven J. Finlayson, Matthew W. Driller, Blaise Dubois, Jean-François Esculier, Christopher Martyn Beaven   +5 more
doaj   +1 more source

Evolution of P[8], P[4], and P[6] VP8* genes of human rotaviruses globally reported during 1974 and 2017: possible implications for rotavirus vaccines in development

Human Vaccines & Immunotherapeutics, 2019
Non-replicating parenteral rotavirus (RV) vaccine candidates are in development in an attempt to overcome the lower efficacy and effectiveness of oral RV vaccines in low-income countries.
Daniel E. Velasquez, Baoming Jiang
doaj   +1 more source

The VP8 fragment of VP4 is the rhesus rotavirus hemagglutinin

Virology, 1991
The amino-terminal trypsin cleavage fragment of VP4, called VP8, was expressed from a recombinant baculovirus in Sf-9 cells. The baculovirus-expressed VP8 protein is antigenically conserved as demonstrated by its recognition by a library of neutralizing monoclonal antibodies. In Sf-9 cell sonicates, the expressed VP8 protein is capable of agglutinating
L, Fiore, H B, Greenberg, E R, Mackow
openaire   +2 more sources

Grass Carp Reovirus Major Outer Capsid Protein VP4 Interacts with RNA Sensor RIG-I to Suppress Interferon Response

Biomolecules, 2020
Diseases caused by viruses threaten the production industry and food safety of aquaculture which is a great animal protein source. Grass carp reovirus (GCRV) has caused tremendous loss, and the molecular function of viral proteins during infection needs ...
Hang Su, Chengjian Fan, Zhiwei Liao, Chunrong Yang, Jihong Liu Clarke, Yongan Zhang, Jianguo Su   +6 more
doaj   +1 more source

Rotavirus genetic diversity, disease association, and temporal change in hospitalized rural Kenyan children [PDF]

, 2010
Background. The effectiveness of rotavirus vaccines will be dependent on the immunity conferred against prevalent and emergent variants causing severe diarrheal disease.
Peenze, Ina, Williams, Thomas N., Peenze, I, Netshifhefhe, Lufuno, Seheri, Mapaseka, De Beer, MC, Nokes, D. James, Nokes, DJ, Seheri, M, Steele, D, De Beer, Mariet C., Williams, TN, Netshifhefhe, L, Williams, Thomas, Page, N, De Beer, De, Abwao, J, Abwao, John, Page, Nicola, Steele, Duncan   +19 more
core   +1 more source

Detection and sequencing of rotavirus among sudanese children

The Pan African Medical Journal, 2017
INTRODUCTION: Diarrheal diseases are a big public health problem worldwide, particularly among developing countries. The current study was conducted to detect and characterize group A rotavirus among admitted children with gastroenteritis to the ...
Magzoub Abbas Magzoub, Naser Eldin Bilal, Jalal Ali Bilal, Mohammad Abdulrahman Alzohairy, Bahaeldin Khalid Elamin, Gasim Ibrahim Gasim   +5 more
doaj   +1 more source

Auxotrophic Lactobacillus Expressing Porcine Rotavirus VP4 Constructed Using CRISPR-Cas9D10A System Induces Effective Immunity in Mice

Vaccines, 2022
Porcine rotavirus (PoRV) mainly causes acute diarrhea in piglets under eight weeks of age and has potentially high morbidity and mortality rates. As vaccine carriers for oral immunization, lactic acid bacteria (LAB) are an ideal strategy for blocking ...
Hailin Zhang, Haiyuan Zhao, Yuliang Zhao, Ling Sui, Fengsai Li, Huijun Zhang, Jiaxuan Li, Yanping Jiang, Wen Cui, Guojie Ding, Han Zhou, Li Wang, Xinyuan Qiao, Lijie Tang, Xiaona Wang, Yijing Li   +15 more
doaj   +1 more source