Results 11 to 20 of about 20,520 (215)

Site-Directed Mutagenesis of Avibirnavirus VP4 Gene

Virology, 2002
Virus protein VP4 of infectious bursal disease virus (IBDV) is a protease which separates VPX and VP3 from the polyprotein. We studied the importance of serine and aspartic acid on cleavage at the VPX/VP4 junction and analysed the role of the proposed H547, D590, and S653 catalytic site using five different mutations on VP4.
Rodríguez-Lecompte, Juan Carlos, Kibenge, Frederick S.B.   +1 more
core   +4 more sources

Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin? [PDF]

mSphere, 2020
The simian polyomavirus SV40 was reported to express Vp4, an N-terminally truncated form of the minor capsid proteins Vp2 and Vp3. Since a missense mutation of the putative Vp4 start codon (Vp2M228I) was found to give reduced progeny release and delayed ...
Stian Henriksen, Christine Hanssen Rinaldo   +1 more
doaj   +2 more sources

Generation of Antibodies against Foot-and-Mouth-Disease Virus Capsid Protein VP4 Using Hepatitis B Core VLPs as a Scaffold [PDF]

Life, 2021
The picornavirus foot-and-mouth disease virus (FMDV) is the causative agent of the economically important disease of livestock, foot-and-mouth disease (FMD). VP4 is a highly conserved capsid protein, which is important during virus entry.
Jessica Swanson, Rennos Fragkoudis, Philippa C. Hawes, Joseph Newman, Alison Burman, Anusha Panjwani, Nicola J. Stonehouse, Tobias J. Tuthill   +7 more
doaj   +2 more sources

Birnavirus VP4 Processing Endopeptidase

, 2013
The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing
Delmas, Bernard, Mundt, Egbert, Gorbalenya, Alexander E.   +2 more
openaire   +4 more sources

Liver resection in selective hepatocellular carcinoma with Vp3 or Vp4 portal vein tumor thrombosis improves prognosis [PDF]

Journal of Liver Cancer
Background/Aim Hepatocellular carcinoma (HCC) tumor thrombi located in the first branch of the portal vein (Vp3) or in the main portal trunk (Vp4) are associated with poor prognosis. This study aimed to investigate the clinicopathological characteristics
Manuel Lim, Jongman Kim, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh   +4 more
doaj   +2 more sources

Seneca valley virus VP4 protein regulates the transcription of different cytokines in vitro [PDF]

Frontiers in Veterinary Science
To understand the effect of Seneca valley virus (SVV) VP4 protein on innate immune factors, the VP4 gene was cloned into the pEGFP-C1 expression plasmid to construct the pEGFP-C1-VP4 recombinant plasmid. After the recombinant plasmid was transfected into
Chaoliang Leng, Yu Ge, Mengfan Ruan, Wenxiao Zhao, Ximei Yang, Sainan Gao, Hongyue Zhai, Dandan Li, Dan Rao, Jianguo Dong   +9 more
doaj   +2 more sources

Outcomes of Hepatocellular Carcinoma involving the Portal Vein Main Trunk and/or the Inferior Vena Cava: Experience From a Multidisciplinary Liver Cancer Clinic. [PDF]

Cancer Med
ABSTRACT Background Vascular invasion by hepatocellular carcinoma (HCC), particularly involving the main portal vein or inferior vena cava (IVC), is associated with poor prognosis. However, contemporary real‐world outcomes and the clinical benefit of liver‐directed therapies (LDT) in this setting are poorly defined.
Liu IC, Zaheer A, Hu C, Shubert C, Lafaro K, Burns WR, Burkhart R, He J, Philosophe B, Zorzi J, Griffith P, Strauss AT, Kim AK, Liddell R, Hong K, Georgiades C, Anders R, Oshima K, Hallab E, Narang A, Ho WJ, Yarchoan M, Baretti M, Meyer J.   +23 more
europepmc   +2 more sources

VP4 Mutation Boosts Replication of Recombinant Human/Simian Rotavirus in Cell Culture

Viruses
Rotavirus A (RVA) is the leading cause of diarrhea requiring hospitalization in children and causes over 100,000 annual deaths in Sub-Saharan Africa. In order to generate next-generation vaccines against African RVA genotypes, a reverse genetics system ...
Roman Valusenko-Mehrkens, Katja Schilling-Loeffler, Reimar Johne, Alexander Falkenhagen   +3 more
doaj   +2 more sources

Hepatic Arterial Infusion Chemotherapy Combined with Radiation Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombosis of the Main Trunk or Bilobar of the Portal Vein

Liver Cancer, 2021
Background: Overall survival of patients with advanced hepatocellular carcinoma (HCC) with Vp4 (tumor thrombosis of the main trunk or bilobar of the portal vein) is extremely poor. Purpose: The purpose of this study is to clarify the prognosis of hepatic
Yumi Kosaka, Tomoki Kimura, Tomokazu Kawaoka, Yutaro Ogawa, Kei Amioka, Kensuke Naruto, Yuki Yoshikawa, Chihiro Kikukawa, Yosuke Suehiro, Kenji Yamaoka, Yuwa Ando, Shinsuke Uchikawa, Kei Morio, Takashi Nakahara, Eisuke Murakami, Shoichi Takahashi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Keigo Chosa, Kazuo Awai, Yasushi Nagata, Kazuaki Chayama, Hiroshi Aikata   +23 more
doaj   +1 more source

VP4 monotype specificities among porcine rotavirus strains of the same VP4 serotype [PDF]

Journal of Virology, 1991
The porcine rotavirus OSU strain was used to produce monoclonal antibodies (MAbs) directed against the outer capsid protein VP4. From two separate fusions, eight MAbs that inhibited hemagglutination activity of the OSU strain were selected. All MAbs immunoprecipitated both the OSU VP4 protein derived from a lysate of infected MA104 cells and the OSU ...
F, Liprandi, I, Rodriguez, C, Piña, G, Larralde, M, Gorziglia   +4 more
openaire   +2 more sources