Results 21 to 30 of about 20,520 (215)
iScience, 2022 Summary: Non-replicating rotavirus vaccines are an alternative strategy to improve the efficacy and safety of rotavirus vaccines. The spike protein VP4, which could be enzymatically cleaved into VP8∗ and VP5∗, is an ideal target for the development of ...
Guoxing Luo +11 more
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Genetic Diversity of Rotavirus Strains in the Era of Vaccination: A Pilot Study from Central Kerala, India [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Rotaviruses cause Acute Gastroenteritis (AGE) in children. Characterisation of rotavirus VP7, VP4 and VP6 genes revealed novel genotypes circulating in the region.
Sincy George +3 more
doaj +1 more source
Pathogens, 2020 The grass carp hemorrhagic disease, caused by the grass carp reovirus (GCRV), has resulted in severe economic losses in the aquaculture industry in China. VP4 and VP35 are outer capsid proteins of GCRV and can induce an immune response in the host. Here,
Changyong Mu +11 more
doaj +1 more source
Establishment of Sandwich ELISA for Quality Control in Rotavirus Vaccine Production
Vaccines, 2022 Non-replicating rotavirus vaccines are alternative strategies that may improve the protective efficacy of rotavirus vaccines in low- and middle-income countries.
Cao Li +9 more
doaj +1 more source
Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments [PDF]
, 2022 Rotavirus (RV) viroplasms are cytosolic inclusions where both virus genome replication and primary steps of virus progeny assembly take place. A stabilized microtubule cytoskeleton and lipid droplets are required for the viroplasm formation, which ...
Wiesendanger, Mahesa +9 more
core +2 more sources
Silencing of the rotavirus NSP4 protein decreases the incidence of biliary atresia in murine model. [PDF]
PLoS ONE, 2011 Biliary atresia is a common disease in neonates which causes obstructive jaundice and progressive hepatic fibrosis. Our previous studies indicate that rotavirus infection is an initiator in the pathogenesis of experimental biliary atresia (BA) through ...
Jiexiong Feng +4 more
doaj +1 more source
The SV40 late protein VP4 is a viroporin that forms pores to disrupt membranes for viral release. [PDF]
PLoS Pathogens, 2011 Nonenveloped viruses are generally released by the timely lysis of the host cell by a poorly understood process. For the nonenveloped virus SV40, virions assemble in the nucleus and then must be released from the host cell without being encapsulated by ...
Smita Raghava +4 more
doaj +1 more source
Trypsin Cleavage Stabilizes the Rotavirus VP4 Spike [PDF]
Journal of Virology, 2001 ABSTRACT Trypsin enhances rotavirus infectivity by an unknown mechanism. To examine the structural basis of trypsin-enhanced infectivity in rotaviruses, SA11 4F triple-layered particles (TLPs) grown in the absence (nontrypsinized rotavirus [NTR]) or presence (trypsinized rotavirus [TR]) of trypsin were characterized to determine ...
S E, Crawford +6 more
openaire +2 more sources
Cleavage of rotavirus VP4 in vivo
Journal of General Virology, 1996 The infectivity of rotavirus particles is dependent on proteolytic cleavage of the outer capsid protein, VP4, at a specific site. This cleavage event yields two fragments, identified as VP5* and VP8*. It has been hypothesized that the particle is more stable, but non-infectious, when VP4 is in the uncleaved state.
J E, Ludert +4 more
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VP4 serotype of the Gottfried strain of porcine rotavirus [PDF]
Journal of Clinical Microbiology, 1993 The antigenic relationships of the VP4 serotype of porcine rotavirus Gottfried strain with other rotaviruses were determined by using antiserum to Gottfried VP4-baculovirus recombinant. This antiserum failed to react significantly with virus of serotypes P1A, P1B, P3, and OSU; however, it reacted with P2 strains.
B, Li, M, Gorziglia
openaire +2 more sources