Results 61 to 70 of about 20,520 (215)

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Rescue of Infectious Rotavirus Reassortants by a Reverse Genetics System Is Restricted by the Receptor-Binding Region of VP4

Viruses, 2021
The rotavirus species A (RVA) capsid contains the spike protein VP4, which interacts with VP6 and VP7 and is involved in cellular receptor binding. The capsid encloses the genome consisting of eleven dsRNA segments.
Alexander Falkenhagen, Marno Huyzers, Alberdina A. van Dijk, Reimar Johne   +3 more
doaj   +1 more source

Hepatic Arterial Infusion Chemotherapy plus either Toripalimab or Sorafenib as First‐line Therapy for Locally Advanced Hepatocellular Carcinoma: A Non‐comparative, Randomized Phase 2 Trial

MedComm, Volume 7, Issue 6, June 2026.
This phase II study explored the efficacy and safety of HAIC plus toripalimab in locally advanced HCC. The primary endpoint was the PFS rate at 6 months. The 6‐month PFS rate was 63.9% in the TorHAIC group and 61.1% in the SoraHAIC group. Treatment with the TorHAIC regimen resulted in a median OS of 20.9 months and a median PFS of 9.1 months.
Zhicheng Lai, Aojie Ge, Hanyue Ouyang, Zichao Wu, Yexing Huang, Qijiong Li, Li Xu, Binkui Li, Minshan Chen, Dongsheng Wen, Anna Kan, Ming Shi, Minke He   +12 more
wiley   +1 more source

VP4 forms a multimeric complex.

, 2014
A. VP4His was incubated in the presence of the membrane-mimetic detergent DHPC or liposomes, or mock-treated (−), resolved by native PAGE and visualised by silver staining.
Mike Strauss (611080), Terry Jackson (363618), Hannah Wenham (611081), Nicola J. Stonehouse (62738), Tobias J. Tuthill (258499), Anusha Panjwani (611079), James J. Chou (48364), David J. Rowlands (258522), James M. Hogle (11757), Sarah Gold (363614)   +9 more
core   +1 more source

Genetic code expansion for chemosensing and chemical actuation of biological functions

Bulletin of the Korean Chemical Society, Volume 47, Issue 5, Page 617-635, May 2026.
Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley   +1 more source

A very late viral protein triggers the lytic release of SV40.

PLoS Pathogens, 2007
How nonenveloped viruses such as simian virus 40 (SV40) trigger the lytic release of their progeny is poorly understood. Here, we demonstrate that SV40 expresses a novel later protein termed VP4 that triggers the timely lytic release of its progeny. Like
Robert Daniels, Dorota Sadowicz, Daniel N Hebert   +2 more
doaj   +1 more source

Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore.

PLoS Pathogens, 2014
Non-enveloped viruses must deliver their viral genome across a cell membrane without the advantage of membrane fusion. The mechanisms used to achieve this remain poorly understood. Human rhinovirus, a frequent cause of the common cold, is a non-enveloped
Anusha Panjwani, Mike Strauss, Sarah Gold, Hannah Wenham, Terry Jackson, James J Chou, David J Rowlands, Nicola J Stonehouse, James M Hogle, Tobias J Tuthill   +9 more
doaj   +1 more source

Specific interactions between rotavirus outer capsid proteins VP4 and VP7 determine expression of a cross-reactive, neutralizing VP4-specific epitope [PDF]

Journal of Virology, 1992
We previously reported that the expression of rotavirus phenotypes by reassortants was affected by recipient genetic background and proposed specific interactions between the outer capsid proteins VP4 and VP7 as the basis for the phenotypic effects (D. Chen, J. W. Burns, M. K. Estes, and R. F. Ramig, Proc. Natl. Acad. Sci. USA 86:3743-3747, 1989).
D Y, Chen, M K, Estes, R F, Ramig
openaire   +2 more sources

Picornavirus entry: membrane permeability induced by capsid protein VP4 [PDF]

, 2013
Non-enveloped viruses such as picornaviruses must penetrate the host cell membrane without the advantage of membrane fusion. This process is thought to involve membrane permeabilisation but the mechanism remains poorly understood.
Panjwani, Anusha
core  

Bluetongue virus VP4 is an RNA-capping assembly line

Nature Structural & Molecular Biology, 2007
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel ...
Sutton, G, Grimes, J, Stuart, D, Roy, P
openaire   +2 more sources