Results 1 to 10 of about 3,985 (161)

Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate [PDF]

Viruses, 2010
A recently solved structure of the aquareovirus virion (Zhang, X; Jin, L.; Fang, Q; Hui, W.H.; Zhou Z.H. 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry.
Shane D. Trask, Kristen M. Guglielmi, John T. Patton   +2 more
doaj   +3 more sources

Molecular Characterization of Outer Capsid Proteins VP5 and VP7 of Grass Carp Reovirus

Viruses, 2022
Aquareovirus, which is a member of the Reoviridae family, was isolated from aquatic animals. A close molecular evolutionary relationship between aquareoviruses and mammalian orthoreoviruses was revealed.
Fuxian Zhang, Diangang Sun, Qin Fang
doaj   +3 more sources

Analysis of Conserved, Computationally Predicted Epitope Regions for VP5 and VP7 Across three Orbiviruses [PDF]

Bioinformatics and Biology Insights, 2018
Orbiviruses are double-stranded RNA viruses that have profound economic and veterinary significance, 3 of the most important being African horse sickness virus (AHSV), bluetongue virus (BTV), and epizootic hemorrhagic disease virus (EHDV).
Bonnie L Russell, Nishal Parbhoo, Samantha Gildenhuys   +2 more
doaj   +3 more sources

Proteomic analysis reveals differential accumulation of small heat shock proteins and late embryogenesis abundant proteins between ABA-deficient mutant vp5 seeds and wild-type Vp5 seeds in maize [PDF]

Frontiers in Plant Science, 2015
ABA is a major plant hormone that plays important roles during many phases of plant life cycle, including seed development, maturity and dormancy, and especially the acquisition of desiccation tolerance.
Xiaolin eWu, Fangping eGong, Le eYang, Xiuli eHu, Fuju eTai, Wei eWang   +5 more
doaj   +3 more sources

VP5* Rearranges when Rotavirus Uncoats [PDF]

Journal of Virology, 2009
ABSTRACT Trypsin primes rotavirus for efficient infectivity by cleaving the spike protein, VP4, into VP8* and VP5*. A recombinant VP5* fragment has a trimeric, folded-back structure. Comparison of this structure with virion spikes suggests that a rearrangement, analogous to those of enveloped virus fusion proteins, may mediate membrane ...
Joshua D, Yoder, Shane D, Trask, T Phuoc, Vo, Mawuena, Binka, Ningguo, Feng, Stephen C, Harrison, Harry B, Greenberg, Philip R, Dormitzer   +7 more
openaire   +2 more sources

Rotavirus Capsid Protein VP5* Permeabilizes Membranes [PDF]

Journal of Virology, 1999
ABSTRACT Proteolytic cleavage of the VP4 outer capsid spike protein into VP8* and VP5* proteins is required for rotavirus infectivity and for rotavirus-induced membrane permeability. In this study we addressed the function of the VP5* cleavage fragment in permeabilizing membranes.
E, Denisova, W, Dowling, R, LaMonica, R, Shaw, S, Scarlata, F, Ruggeri, E R, Mackow   +6 more
openaire   +2 more sources

Oral PLGA-based DNA vaccines using interferons as adjuvants remarkably promote the immune protection of grass carp (Ctenopharyngodon idella) against GCRV infection

Water Biology and Security, 2023
Grass carp hemorrhagic disease caused by grass carp reovirus (GCRV) results in significant economic losses to the global grass carp aquaculture industry. Oral vaccination is an ideal choice for disease precaution in aquaculture. However, oral vaccine can
Chaolin Jiang, Xingchen Huo, Lingjie Tang, Meidi Hu, Chunrong Yang, Daji Luo, Jianguo Su   +6 more
doaj   +1 more source

Cypovirus capsid protein VP5 has nucleoside triphosphatase activity [PDF]

Virologica Sinica, 2017
As a major protein of cypovirus capsid shell,VP5 performs as the clamp protein to stabilize the capsid shell structure (Yu et al.,2008).And as a part of viral RNA (vRNA) replication machinery,VP5 has been found to possess an ATP-independent RNA chaperoning activity (Yang et al.,2014).Here,we report that VP5 also has the nucleoside triphosphatase ...
Jie Yang, Qi Qian, Teng-Feng Li, Xueli Yang, Sok Jin Won, Xi Zhou   +5 more
openaire   +2 more sources

The VP5 Domain of VP4 Can Mediate Attachment of Rotaviruses to Cells [PDF]

Journal of Virology, 2000
ABSTRACT Some animal rotaviruses require the presence of sialic acid (SA) on the cell surface to infect the cell. We have isolated variants of rhesus rotavirus (RRV) whose infectivity no longer depends on SA. Both the SA-dependent and -independent interactions of these viruses with the cell are mediated by the virus spike protein
S, Zárate, R, Espinosa, P, Romero, E, Méndez, C F, Arias, S, López   +5 more
openaire   +5 more sources

Enhanced and Extended Anti-Hypertensive Effect of VP5 Nanoparticles [PDF]

International Journal of Molecular Sciences, 2016
Hypertension has become a significant global public health concern and is also one of the most common risk factors of cardiovascular disease. Recent studies have shown the promising result of peptides inhibiting angiotensin converting enzyme (ACE) in lowering the blood pressure in both animal models and humans.
Yu, Ting, Zhao, Shengnan, Li, Ziqiang, Xu, Bei, Fang, Dailong, Wang, Fazhan, Zhang, Zhi, He, Lili, Song, Xiangrong, Yang, Jian, Wang, Yi   +10 more
openaire   +3 more sources