Results 71 to 80 of about 2,910 (199)

Cryo-EM structures of Banna virus in multiple states reveal stepwise detachment of viral spikes

Nature Communications
Banna virus (BAV) is the prototype Seadornavirus, a class of reoviruses for which there has been little structural study. Here, we report atomic cryo-EM structures of three states of BAV virions—surrounded by 120 spikes (full virions), 60 spikes (partial
Zhiqiang Li, Han Xia, Guibo Rao, Yan Fu, Tingting Chong, Kexing Tian, Zhiming Yuan, Sheng Cao   +7 more
doaj   +1 more source

Interaction Between Microbiota and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and New Therapeutic Opportunities

MedComm, Volume 6, Issue 7, July 2025.
This review systematically concludes the interaction between microbiota and immunity. We introduce six phyla: Bacteroidetes, Firmicutes, Actinobacteria, Proteobacteria, Fusobacteria, and Verrucomicrobia. We also elucidate molecular mechanisms, biological functions, diseases, and new therapeutic opportunities between microbiota and immunity. .
Jingjing Zeng, Zimeng He, Guoqing Wang, Yuxin Ma, Feng Zhang   +4 more
wiley   +1 more source

A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and Plasmodium as a Combination Vaccine Candidate

Vaccines
Background: Noroviruses, which cause epidemic acute gastroenteritis, and Plasmodium parasites, which lead to malaria, are two infectious pathogens that pose threats to public health.
Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Xi Jiang, Ming Tan   +5 more
doaj   +1 more source

Reassortment and genomic analysis of a G9P[8]-E2 rotavirus isolated in China

Virology Journal, 2023
Objective To isolate a prevalent G9P[8] group A rotavirus (RVA) (N4006) in China and investigate its genomic and evolutionary characteristics, with the goal of facilitating the development of a new rotavirus vaccine.
Rui Peng, Dandi Li, Jindong Wang, Guangping Xiong, Mengxuan Wang, Dan Liu, Yuhang Wei, Lili Pang, Xiaoman Sun, Huiying Li, Xiangyu Kong, Saleha Shahar, Zhaojun Duan   +12 more
doaj   +1 more source

Phenotyping, genome‐wide dissection, and prediction of maize root architecture for temperate adaptability

iMeta, Volume 4, Issue 2, April 2025.
This study dissects the genetic architecture of maize Root System Architecture, identifying significant root trait differences between tropical/subtropical and temperate lines. Using genome‐wide association study, 3511 genes were linked to root morphology, weight, and slice traits.
Weijun Guo, Fanhua Wang, Jianyue Lv, Jia Yu, Yue Wu, Hada Wuriyanghan, Liang Le, Li Pu   +7 more
wiley   +1 more source

Human Group C Rotavirus VP8*s Recognize Type A Histo-Blood Group Antigens as Ligands

, 2018
Group/species C rotaviruses (RVCs) have been identified as important pathogens of acute gastroenteritis (AGE) in children, family-based outbreaks, as well as animal infections. However, little is known regarding their host-specific interaction, infection,
Hongling Wen, George F. Gao, Mengxuan Wang, Xin Cong, Jianxun Qi, Ruchao Peng, Wengang Chai, Qing Zhang, Ming Tan, Dandi Li, Lihong Wang, Zhaojun Duan, Hong Wang, Xiaoman Sun   +13 more
core   +1 more source

Severe Diarrhea Outbreaks in Newborn Piglets in China Associated With Porcine Rotavirus B

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Rotavirus B (RVB) is among the enteric pathogens that can cause gastroenteritis in humans and various animals. However, severe diarrhea in newborn piglets has rarely been reported to be linked to porcine RVB (PoRVB). From 2023 to 2024, outbreaks of newborn piglet diarrhea with 20%–50% morbidity and 4%–10% mortality occurred in three herds situated in ...
Mingkai Sun, Tianzeng Li, Wugang Liu, Zhixing Guo, Zunbao Wang, Jianfeng Jiang, Qingxian Li, Biao He, Yidi Guo, Wenjie Gong, Xing-Yi Ge   +10 more
wiley   +1 more source

Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates [PDF]

Vaccine, 2012
Two currently licensed live oral rotavirus vaccines (Rotarix® and RotaTeq®) are highly efficacious against severe rotavirus diarrhea. However, the efficacy of such vaccines in selected low-income African and Asian countries is much lower than that in middle or high-income countries.
Xiaobo, Wen, Dianjun, Cao, Ronald W, Jones, Jianping, Li, Shousun, Szu, Yasutaka, Hoshino   +5 more
openaire   +2 more sources

Design of multi-epitope vaccine against porcine rotavirus using computational biology and molecular dynamics simulation approaches

Virology Journal
Porcine Rotavirus (PoRV) is a significant pathogen affecting swine-rearing regions globally, presenting a substantial threat to the economic development of the livestock sector.
Xiaochen Zhu, Xinyuan Wang, Tingting Liu, Dongchao Zhang, Tianming Jin   +4 more
doaj   +1 more source

Circulating rotavirus strains in children with acute gastroenteritis in Iran, 1986 to 2023 and their genetic/antigenic divergence compared to approved vaccines strains (Rotarix, RotaTeq, ROTAVAC, ROTASIIL) before mass vaccination: Clues for vaccination policy makers

Virus Research
In the present study, first, rotaviruses that caused acute gastroenteritis in children under five years of age during the time before the vaccine was introduced in Iran (1986 to 2023) are reviewed.
Somayeh Jalilvand, Tayebeh Latifi, Atefeh Kachooei, Mahtab Mirhoseinian, Somayeh-Sadat Hoseini-Fakhr, Farzane Behnezhad, Farzin Roohvand, Zabihollah Shoja   +7 more
doaj   +1 more source