Results 71 to 80 of about 2,319 (158)

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+

PLOS Pathogens
Rotaviruses infect cells by delivering into the cytosol a transcriptionally active inner capsid particle (a "double-layer particle": DLP). Delivery is the function of a third, outer layer, which drives uptake from the cell surface into small vesicles from which the DLPs escape.
Marilina de Sautu, Tobias Herrmann, Gustavo Scanavachi, Simon Jenni, Stephen C. Harrison   +4 more
openaire   +3 more sources

Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC ‐ What is Coming Next?

Advanced Science, Volume 11, Issue 33, September 4, 2024.
This review focuses on the main challenge of oral peptide delivery ‐ overcoming the epithelial barrier. With many peptide drugs in development, there is a huge unmet need for more efficient intestinal permeation enhancers (PEs). Biophysiological fundamentals are explained while highlighting possible new targets.
Marilena Bohley, Jean‐Christophe Leroux   +1 more
wiley   +1 more source

Vaccine process technology—A decade of progress

Biotechnology and Bioengineering, Volume 121, Issue 9, Page 2604-2635, September 2024.
Abstract In the past decade, new approaches to the discovery and development of vaccines have transformed the field. Advances during the COVID‐19 pandemic allowed the production of billions of vaccine doses per year using novel platforms such as messenger RNA and viral vectors.
Barry Buckland, Gautam Sanyal, Todd Ranheim, David Pollard, Jim A. Searles, Sue Behrens, Stefanie Pluschkell, Jessica Josefsberg, Christopher J. Roberts   +8 more
wiley   +1 more source

Revolutionizing disease treatment through bioengineered probiotics and glucagon‐like peptide 1 (GLP‐1) based strategies: A path towards effective cures

Food Bioengineering, Volume 3, Issue 3, Page 280-300, September 2024.
The advancement in technologies has enabled bioengineering of probiotics for targeting particular cells and tissues instead of the entire body. GLP‐1 peptides which are incretin hormones have been shown to be more effective when combined with engineered probiotics.
Smriti Jain, Adarsh Kumar Shukla, Deepika, Surbhi Panwar, Anita Kumari, Ashok Kumar Yadav, Ashwani Kumar   +6 more
wiley   +1 more source

A Reverse Genetics System for Cypovirus Based on a Bacmid Expressing T7 RNA Polymerase

Viruses, 2019
Dendrolimus punctatus cypovirus (DpCPV), belonging to the genus Cypovirus within the family Reoviridae, is considered the most destructive pest of pine forests worldwide. DpCPV has a genome consisting of 10 linear double-stranded RNA segments.
Gaobo Zhang, Jian Yang, Fujun Qin, Congrui Xu, Jia Wang, Chengfeng Lei, Jia Hu, Xiulian Sun   +7 more
doaj   +1 more source

Examination of In Vivo Mutations in VP4 (VP8*) of the Rotarix^® Vaccine from Shedding of Children Living in the Amazon Region

Viruses
Group A rotaviruses (RVAs) remain the leading cause of acute gastroenteritis (AGE) in young children in low- and middle-income countries. In Brazil, the oral attenuated RVA vaccine (Rotarix®), monovalent genotype G1P[8], is distributed by the national ...
Mauro França Silva, Beatriz Vieira da Silva, Emanuelle Ramalho, Yan Cardoso Pimenta, Leonardo Luiz Pimenta da Silva, Laricy da Silva Vieira, Maria da Penha Trindade Pinheiro Xavier, Alberto Ignacio Olivares Olivares, José Paulo Gagliardi Leite, Marcia Terezinha Baroni de Moraes   +9 more
doaj   +1 more source

Severe diarrhea outbreak in beef calves (Bos indicus) caused by G6P[11], an emergent genotype of bovine rotavirus group A

Pesquisa Veterinária Brasileira, 2014
The episodes of diarrhea caused by neonatal bovine rotavirus group A (BoRVA) constitute one of the major health problems in the calf rearing worldwide. The main G (VP7) and P (VP4) genotypes of BoRVA strains involved in the etiology of diarrhea in calves
Thais N.S. Medeiros, Elis Lorenzetti, Alice F. Alfieri, Amauri A. Alfieri   +3 more
doaj   +1 more source

Rotavirus Serotype G9P[8] and Acute Gastroenteritis Outbreak in Children, Northern Australia

Emerging Infectious Diseases, 2004
During 2001, an outbreak of severe acute gastroenteritis swept through Central and northern Australia and caused serious disruption to health services. We tracked and characterized the rotavirus strain implicated in the outbreak.
Carl D. Kirkwood, Nada Bogdanovic-Sakran, Graeme Barnes, Ruth Bishop   +3 more
doaj   +1 more source

Safety and immunogenicity of a parenterally administered rotavirus VP8 subunit vaccine in healthy adults

Vaccine, 2015
The P2-VP8 subunit vaccine for the prevention of rotavirus gastroenteritis is comprised of a truncated VP8 subunit protein from the rotavirus Wa strain (G1[P8]) fused to the tetanus toxin P2 epitope, and adsorbed on aluminum hydroxide for intramuscular administration.Three groups of 16 adults were randomized to receive three injections of P2-VP8 (12 ...
Fix, Alan D., Harro, Clayton, McNeal, Monica, Dally, Len, Flores, Jorge, Robertson, George, Boslego, John W., Cryz, Stanley   +7 more
openaire   +2 more sources

Immunological response to recombinant VP8* subunit protein of bovine rotavirus in pregnant cattle

Journal of General Virology, 1995
Bovine rotavirus VP8*, N-terminal trypsin cleavage product of VP4, was produced in Escherichia coli. To examine if this antigen could induce neutralizing antibody responses, different species of animals were immunized with the recombinant VP8* protein. The VP8* antigen was found to stimulate a neutralizing immune response in rabbits.
J, Lee, L A, Babiuk, R, Harland, E, Gibbons, Y, Elazhary, D, Yoo   +5 more
openaire   +2 more sources