Results 81 to 90 of about 2,910 (199)

Biotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus

Cell Biochemistry and Function, Volume 42, Issue 8, December 2024.
ABSTRACT Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live‐attenuated vaccines. Challenges such as limited efficacy in low‐income regions, safety concerns for immunocompromised individuals, and cold‐chain dependency necessitate alternative vaccine strategies ...
Mukta Prajapati, Pooja Malik, Astha Sinha, Honey Yadav, Yachna K. Jaiwal, Yogesh K. Ahlawat, Darshna Chaudhary, Ranjana Jaiwal, Nisha Sharma, Pawan K. Jaiwal, Vijay K. Chattu   +10 more
wiley   +1 more source

Eco-alternative treatments for Vibrio parahaemolyticus and V. cholerae biofilms from shrimp industry through Eucalyptus (Eucalyptus globulus) and Guava (Psidium guajava) extracts: A road for an Ecuadorian sustainable economy.

PLoS ONE
Understanding how environmental variables influence biofilm formation becomes relevant for managing Vibrio biofilm-related infections in shrimp production.
Nicolás Renato Jara-Medina, Dario Fernando Cueva, Ariana Cecibel Cedeño-Pinargote, Arleth Gualle, Daniel Aguilera-Pesantes, Miguel Ángel Méndez, Lourdes Orejuela-Escobar, Diego F Cisneros-Heredia, Rebeca Cortez-Zambrano, Nelson Miranda-Moyano, Eduardo Tejera, António Machado   +11 more
doaj   +1 more source

Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC ‐ What is Coming Next?

Advanced Science, Volume 11, Issue 33, September 4, 2024.
This review focuses on the main challenge of oral peptide delivery ‐ overcoming the epithelial barrier. With many peptide drugs in development, there is a huge unmet need for more efficient intestinal permeation enhancers (PEs). Biophysiological fundamentals are explained while highlighting possible new targets.
Marilena Bohley, Jean‐Christophe Leroux   +1 more
wiley   +1 more source

The PADMET platform - pharmacokinetic characterization of carbohydrate mimetics [PDF]

, 2012
More than two decades ago it was realized that drug discovery and development strategies focusing exclusively on affinity enhancement and potency are unsuccessful.
Wittwer, Matthias Beat
core   +1 more source

Rotavirus A Infection Prevalence and Spatio-Temporal Genotype Shift among Under-Five Children in Amhara National Regional State, Ethiopia: A Multi-Center Cross-Sectional Study

Vaccines
Background: Globally, rotavirus (RV) A (RVA) is the most common cause of severe and sometimes fatal diarrhea in young children. It is also the major cause of acute gastroenteritis among children in Ethiopia.
Debasu Damtie, Aschalew Gelaw, Yitayih Wondimeneh, Yetemwork Aleka, Maryssa K. Kick, Zemene Tigabu, Ulrich Sack, Zelalem H. Mekuria, Anastasia N. Vlasova, Belay Tessema   +9 more
doaj   +1 more source

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+

PLOS Pathogens
Rotaviruses infect cells by delivering into the cytosol a transcriptionally active inner capsid particle (a "double-layer particle": DLP). Delivery is the function of a third, outer layer, which drives uptake from the cell surface into small vesicles from which the DLPs escape.
Marilina de Sautu, Tobias Herrmann, Gustavo Scanavachi, Simon Jenni, Stephen C. Harrison   +4 more
openaire   +3 more sources

Vaccine process technology—A decade of progress

Biotechnology and Bioengineering, Volume 121, Issue 9, Page 2604-2635, September 2024.
Abstract In the past decade, new approaches to the discovery and development of vaccines have transformed the field. Advances during the COVID‐19 pandemic allowed the production of billions of vaccine doses per year using novel platforms such as messenger RNA and viral vectors.
Barry Buckland, Gautam Sanyal, Todd Ranheim, David Pollard, Jim A. Searles, Sue Behrens, Stefanie Pluschkell, Jessica Josefsberg, Christopher J. Roberts   +8 more
wiley   +1 more source

Expresión y purificación de las proteínas estructurales del rotavirus VP5* y VP8* en bacterias E. coli BL21(DE3)

, 2013
Título en ingles: Expression and purification of rotavirus structural proteins VP5* and VP8* in bacteria E. coli BL21(DE3) Resumen La caracterización de las proteínas estructurales del rotavirus y de las proteínas de la superficie de la célula hospedera ...
Acosta, Orlando, Carlos Arturo Guerrero, Moreno, Luz Yurany, Orlando Acosta, Luz Yurany Moreno, Guerrero, Carlos Arturo   +5 more
core  

Revolutionizing disease treatment through bioengineered probiotics and glucagon‐like peptide 1 (GLP‐1) based strategies: A path towards effective cures

Food Bioengineering, Volume 3, Issue 3, Page 280-300, September 2024.
The advancement in technologies has enabled bioengineering of probiotics for targeting particular cells and tissues instead of the entire body. GLP‐1 peptides which are incretin hormones have been shown to be more effective when combined with engineered probiotics.
Smriti Jain, Adarsh Kumar Shukla, Deepika, Surbhi Panwar, Anita Kumari, Ashok Kumar Yadav, Ashwani Kumar   +6 more
wiley   +1 more source

Expresión y purificación de las proteínas recombinantes estructurales VP5, VP6 y VP8 del rotavirus / Expression and purification of recombinant structural rotavirus proteins VP5, VP6 and VP8

, 2010
La identificación de posibles receptores del rotavirus y su participación durante la unión y penetración del virus en células suceptibles a la infección han requerido la expresión y purificación de las proteínas virales. Por tanto, el objetivo general de
Moreno Rueda, Luz Yurany
core