Results 131 to 140 of about 72,933 (233)

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Diamine Grafting of Pyrazole‐Based MOF‐303 for Diluted‐Source CO2 Capture

Small, Volume 22, Issue 23, 22 April 2026.
Vapor‐phase diffusion of ethylenediamine (EDA) into the pyrazole‐based MOF‐303 framework enables efficient amine grafting via pyrazole deprotonation and ion‐pair–stabilized hydrogen bonding with the pore walls. Spectroscopic analyses elucidate the interaction, while breakthrough experiments confirm the material's performance and cyclability.
Giuseppe Mastronardi, Jacopo Perego, Charl Xavier Bezuidenhout, Wim Temmerman, Veronique Van Speybroeck, Valentina Crocellà, Silvia Bracco, Nello Li Pira, Angiolina Comotti, Silvia Bordiga   +9 more
wiley   +1 more source

Ginsenoside Rh1 Suppresses Vesicular Stomatitis Virus Replication by Inhibiting Autophagy to Promote Immune Responses

Microorganisms
Vesicular stomatitis virus (VSV), a member of the Vesiculovirus genus within the Rhabdoviridae family, is a widespread pathogen affecting all hoofed livestock species, leading to reduced animal growth and productivity.
Hongmei Chen, Qinglu Zhao, Dingcheng Wei, Zhanying Hu, Xueliang Zhu, Rui Zhang   +5 more
doaj   +1 more source

Senescent Factors Suppress Innate Antiviral Immunity in Aged Mice via Two Distinct Mechanisms

Aging Cell, Volume 25, Issue 4, April 2026.
Four secreted factors from senescent cells, including GDF15, IGF1, IL1α, and IL6, cooperatively suppress antiviral innate immunity. GDF15/IGF1 trigger AKT‐MEK‐mediated inactivation of GSK3β, leading to suppression of the TBK1‐IRF3 axis, whereas IL1α/IL6 induce p52 and RelB to suppress transcription of antiviral genes.
Xu Zhang, Qi Zhang, Li Wang, Shu Li, Hong‐Bing Shu   +4 more
wiley   +1 more source

Development of a vesicular stomatitis virus pseudotyped with herpes B virus glycoproteins and its application in a neutralizing antibody detection assay

mBio
Herpes B virus (BV) is a zoonotic virus and belongs to the genus Simplexvius, the same genus as human herpes simplex virus (HSV). BV typically establishes asymptomatic infection in its natural hosts, macaque monkeys.
Hitomi Kinoshita, Souichi Yamada, Takuma Ogawa, Phu Hoang Anh Nguyen, Shizuko Harada, Madoka Kawahara, Keita Ishijima, Ken Maeda, Hideki Ebihara, Shuetsu Fukushi   +9 more
doaj   +1 more source

Repeated harvest enables efficient production of VSV-GP

Frontiers in Bioengineering and Biotechnology
Viral products keep gaining importance in multiple therapeutic fields. Considering the scale and production slot limitations, optimizing the outcome of every manufacturing batch is essential to minimize costs and make this therapeutic modality broadly available to patients.
Rebecca Habisch, Peter Neubauer, Jorge Soza-Ried, Eva Puschmann   +3 more
openaire   +3 more sources

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, Volume 293, Issue 7, Page 2086-2097, April 2026.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source

VSV-hIFNbeta-NIS [PDF]

, 2020
openaire   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, Volume 56, Issue 4, Page 420-435, April 2026.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Auto‐inducible expression of chimeric antigen receptor T cells using the NR4A1 promoter

Immunology &Cell Biology, Volume 104, Issue 4, Page 381-395, April 2026.
The NR4A1 promoter is a compact auto‐inducible promoter to drive CAR expression in T cells. Compared with EF1α, or existing synthetic antigen‐inducible promoters, NR4A1 is more compact and ensures that resting CAR T cells express reduced baseline CAR. NR4A1 allows rapid induction upon antigen encounter with reduced T‐cell exhaustion.
Samuel WJ Smith‐Bell, Joshua C Halpin, Phillip K Darcy, Thiloma Liyanage, Lachlan J Dobson, Alexander D McLellan   +5 more
wiley   +1 more source