Results 121 to 130 of about 72,933 (233)

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of TCE‐secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, Volume 13, Issue 19, 2 April 2026.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, Volume 13, Issue 22, 17 April 2026.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Oncolytic vesicular stomatitis virus alone or in combination with JAK inhibitors is effective against ovarian cancer

Molecular Therapy: Oncology
Therapy-resistant ovarian cancers have a poor prognosis and novel effective treatment options are urgently needed. In this study, we evaluated the therapeutic efficacy of the oncolytic vesicular stomatitis virus (VSV) against a panel of patient-derived ...
Karen Geoffroy, Victor Mullins-Dansereau, Kim Leclerc-Desaulniers, Mélissa Viens, Marie-Claude Bourgeois-Daigneault   +4 more
doaj   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Transgelin Expression in Activated Cancer‐Associated Fibroblasts Regulates Stromal Contractility and Promotes Colon Cancer Progression

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Transgelin is an actin‐binding protein that promotes cancer progression via activation of cancer‐associated fibroblasts and has been identified as a prognostic marker. However, its distribution and functional role in colon cancer remain unclear. In this study, we aimed to elucidate the mechanistic role of transgelin in colon cancer progression
Ryuji Okamoto, Tetsuro Hiroi, Yuka Nakamura, Hiroko Hashimoto, Shingo Sakashita, Naoya Sakamoto, Shumpei Ishikawa, Horacio Cabral, Triantafyllos Stylianopoulos, Yuichiro Tsukada, Atsushi Ochiai, Tomonori Yano, Masaaki Ito, Genichiro Ishii, Motohiro Kojima   +14 more
wiley   +1 more source

Biodegradable, Breathable, and Skin‐Friendly Solution‐Blown Quercetin Nanofibers for Antiviral Nonwoven Filter

EcoMat, Volume 8, Issue 4, April 2026.
A nanofiber filter of quercetin and poly(ethylene oxide), produced through a solution‐blowing technique, serves as an eco‐friendly, high‐performance alternative for antiviral mask filters. The resulting material combines effective particle filtration with excellent breathability, robust mechanical strength, and rapid biodegradability, while also ...
Dogun Park, Joo‐Hyun Hong, Zijun Li, Yeongtak Son, Yea Jung Choi, Sullim Lee, Hyun‐Woo Kim, Daekyu Choi, Kiyong Kim, Yun Seok Joh, Do‐Kyun Kim, Hee Min Yoo, Ki Hyun Kim, Seongpil An   +13 more
wiley   +1 more source

ATG7 Limits Basal Antiviral Gene Expression and Moderately Promotes VSV Replication in Mammalian Non-Immune Cells

Pathogens
The autophagy regulator ATG7 helps maintain cellular homeostasis and has been suggested to modulate aspects of antiviral immune responses. In Drosophila, ATG7-dependent autophagy contributes to host resistance to vesicular stomatitis virus (VSV), a ...
Xiaohan Tong, Ruixue Wang, Yaxin Liu, Malia B. Potts, Shondra M. Pruett-Miller, Michael A. Whitt, Weikuan Gu, Kui Li   +7 more
doaj   +1 more source

Guidance for Documentation of Therapeutic Apheresis Interventions in the Medical Record: An American Society for Apheresis (ASFA) Practice Perspective

Journal of Clinical Apheresis, Volume 41, Issue 2, April 2026.
ABSTRACT In 2007, the American Society for Apheresis (ASFA) published guidance for physician documentation related to oversight of therapeutic apheresis (TA). Due to 21st century changes in healthcare delivery, the ASFA Board of Directors (BOD) charged its Public Affairs and Advocacy Committee (PAAC) to coordinate a review and update of the guidance ...
Chester Andrzejewski, Yanhua Li, Ding Wen Wu, Gustaaf De Ridder, Jan C. Hofmann, Susan Knight, Sajjad Hassan, Nicole A. Aqui, Walter Linz   +8 more
wiley   +1 more source

Transcriptome analysis of long non-coding RNA and mRNA Profiles in VSV-infected BHK-21 Cells

BMC Genomics
Background Vesicular stomatitis virus (VSV) is a typical non-segmented negative-sense RNA virus of the genus Vesiculovirus in the family Rhabdoviridae. VSV can infect a wide range of animals, including humans, with oral blister epithelial lesions. VSV is
Wuweiyi Han, Xiaojuan Fei, Fan Yang, Xintong Sun, Jianshe Yang, Jinxin Qiu, Luhua Zhang, Wenhui Zhang, Guohua Chen, Wei Han, Xiaobo He, Yongsheng Liu, Weike Li   +12 more
doaj   +1 more source

Glioblastoma Cells Expressing Oncogenic EGFR Release Multiple Extracellular Vesicle Subpopulations Positive or Negative for EGFR

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Extracellular vesicle (EV) heterogeneity is well documented but poorly defined. This is especially important in cancer where EVs serve as carriers of unique oncogenic macromolecules that can be transferred to recipient cells or targeted for liquid biopsy diagnostics.
Elham Pishavar, Fereshteh Shojaei‐Ghahrizjani, Brian Meehan, Nadim Tawil, Cristiana Spinelli, Dongsic Choi, Fang Cheng Wong, Mahsa Jalali, Janusz Rak   +8 more
wiley   +1 more source