Results 71 to 80 of about 1,438,104 (293)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Communally established cattle feedlots as a sustainable livelihood option for climate change resilience and food security in sub-Saharan Africa: a systematic review

Frontiers in Sustainable Food Systems
Climate change poses a significant threat to agriculture and livestock production in sub-Saharan Africa, a region heavily reliant on livestock for smallholder farmers’ livelihoods.
Mhlangabezi Slayi, Leocadia Zhou, Patrick Nyambo, Ishmael Festus Jaja, Shadreck Muchaku   +4 more
doaj   +1 more source

The role of adult socioeconomic and relational reserves regarding the effect of childhood misfortune on late-life depressive symptoms

SSM: Population Health, 2019
Background: Childhood misfortune is associated with late-life depressive symptoms, but it remains an open question whether adult socioeconomic and relational reserves could reduce the association between childhood misfortune and late-life depressive ...
Martina von Arx, Boris Cheval, Stefan Sieber, Dan Orsholits, Eric Widmer, Matthias Kliegel, Idris Guessous, Michelle Kelly-Irving, Delphine S. Courvoisier, Matthieu P. Boisgontier, Stéphane Cullati   +10 more
doaj   +1 more source

Physical vulnerability to dynamic flooding: Vulnerability curves and vulnerability indices

Journal of Hydrology, 2022
Vulnerability analysis is crucial to assess natural hazard risk. Methods for vulnerability assessment include indices as well as vulnerability curves. Vulnerability curves make use of empirical data to show the relationship between the process intensity and the resulting degree of loss on each affected building whereas vulnerability indices are based ...
Maria Papathoma-Köhle, Matthias Schlögl, Lea Dosser, Florian Roesch, Marco Borga, Marcel Erlicher, Margreth Keiler, Sven Fuchs   +7 more
openaire   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mental health of undocumented migrants and migrants undergoing regularization in Switzerland: a cross-sectional study

BMC Psychiatry, 2021
Background Undocumented migrants live and work in precarious conditions. Few studies have explored the mental health consequences of such environment.
Julien Fakhoury, Claudine Burton-Jeangros, Liala Consoli, Aline Duvoisin, Delphine Courvoisier, Yves Jackson   +5 more
doaj   +1 more source

Prevalence and clinical features of anxiety disorders: Tunisian study about 436 subjects

European Psychiatry, 2022
Introduction Anxiety disorders represent one of the most common mental disorders following a chronic course. Objectives The aim of our study is to determine the prevalence, incidence and clinical characteristics of these disorders.
M. Jabeur, L. Gassab, A. Ayadi, B. Ben Mohamed, F. Zaafrane, L. Gaha   +5 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Dynamic response mechanism and cumulative damage effect of Al0.3CoCrFeNi high-entropy alloy under repeated impact loading

Baozha yu Chongji
To investigate the evolution of phase structure, dislocation distribution, energy absorption capacity, and impact accumulation effect of high-entropy alloys (HEA) under shock loading, molecular dynamics simulations were employed to systematically analyze
Jialin CHEN, Shutao LI, Ming AN, Longyun ZHOU, Sheng ZHANG, Rongxin LI, Yeqing CHEN   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source