Results 51 to 60 of about 144,472 (263)
Frontiers in Marine Science, 2019 Ship traffic in Northwestern European seas is intense and continuing to increase, posing a threat to vulnerable seabird species as a result of disturbance.
Katharina Leonia Fliessbach +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Seismic risk assessment of algerian buildings in urban area
Journal of Civil Engineering and Management, 2013 The recent earthquakes in Algeria have caused significant human and economic losses. The frequent occurrence of damaging earthquakes clearly demonstrates the urgent need of study on seismic risk assessment methods of buildings to effectively reduce the ...
Fatima Zohra Baba Hamed +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Arctic Permafrost Vulnerability Index
SustainabilityAs permafrost thaw accelerates, Arctic communities living on permafrost face new challenges that require the development of local adaptation policies. Vulnerability assessments have not yet been applied in the context of permafrost thaw. We develop a conceptual framework to assess vulnerabilities related to permafrost thaw in the Arctic Circumpolar ...
Ramage, Justine +7 more
openaire +2 more sources
Exposer Intensity, Vulnerability Index And Landscape Change Assessment In Olomouc, Czech Republic [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015 The objective of this study is vulnerability and exposer intensity due to land use change in Olomouc, Czech Republic. Vulnerability assessment with exposer intensity to land use/cover change is an important step for enhancing the understanding and ...
M. S. Boori, V. Vozenilek, K. Choudhary
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source