Results 31 to 40 of about 33,525 (258)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez +12 more
wiley +1 more source
Ligation of macrophage Fcγ receptors recapitulates the gene expression pattern of vulnerable human carotid plaques. [PDF]
PLoS ONE, 2011 Stroke is a leading cause of death in the United States. As ∼60% of strokes result from carotid plaque rupture, elucidating the mechanisms that underlie vulnerability is critical for therapeutic intervention.
Michelle R Lennartz +8 more
doaj +1 more source
Redox Biology, 2023 NADPH oxidases 2 (NOX2) is the main source of ROS in macrophages, which plays a critical role in the formation of atherosclerosis. However, effects of NOX2 inhibition on established vulnerable plaques and the potential role involved remain unclear.
Yue Wang +7 more
doaj +1 more source
The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen +5 more
wiley +1 more source
Advanced Functional Materials, EarlyView.This study presents an injectable hydrogel that responds to Pseudomonas aeruginosa infection by releasing a dual‐phage cocktail on demand. The system degrades selectively in infected wounds, enhances phage localization and stability, and shows potent antibiofilm activity and biocompatibility in an ex vivo human skin model—offering a promising strategy ...
Siyuan Tao +9 more
wiley +1 more source
Seeing inside the Body Using Wearable Sensing and Imaging Technologies
Advanced Healthcare Materials, EarlyView.This review explores wearable technologies for noninvasive internal health monitoring. It categorizes approaches into indirect sensing (e.g., bioelectrical and biochemical signals) and direct imaging (e.g., wearable ultrasound and EIT), highlighting multimodal integration and system‐level innovation toward personalized, continuous healthcare.
Sumin Kim +3 more
wiley +1 more source
The Impact of Coronary Artery Calcification on Long-Term Cardiovascular Outcomes
Journal of Interdisciplinary Medicine, 2021 Decades of research and experimental studies have investigated various strategies to prevent acute coronary events. However, significantly efficient preventive methods have not been developed and still remains a challenge to determine if a coronary ...
Mitra Noémi +5 more
doaj +1 more source
Advanced Materials, EarlyView.This work has developed a dual enzyme‐mimicking and ultrasound‐responsive Nb2C‐Pt@HA‐PEG nanozyme. ROS‐eliminating and antiinflammatory capability of Nb2C‐Pt@HA‐PEG under US irradiation are demonstrated on macrophages and endothelial cells in vitro. Nb2C‐Pt@HA‐PEG‐mediated sonocatalytic therapy exerts an outstanding anti‐atherosclerosis efficacy by ...
Qianqian Bai +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld +23 more
wiley +2 more sources
Advanced Materials, EarlyView.A rapid glass‐substrate 3D microfabrication method creates anatomically accurate carotid artery‐on‐a‐chip models from stroke patient scans in 2 h. These miniaturized devices replicate patient‐specific blood vessel geometry and flow patterns, enabling real‐time imaging of clot formation under controlled injury.
Yunduo Charles Zhao +14 more
wiley +1 more source