Results 71 to 80 of about 1,471,775 (278)

Increased macrophage activity in coronary plaques in patients with acute coronary syndrome and familial hypercholesterolemia

International Journal of Cardiology. Cardiovascular Risk and Prevention
Background: Patients with familial hypercholesterolemia (FH) experience acute coronary syndrome (ACS) at a younger age and have a higher risk of recurrent coronary events. The study aimed to elucidate the morphological characteristics of coronary plaques
Toshiyuki Iwaya, Yoshiyasu Minami, Kiyoshi Asakura, Takako Nagata, Masahiro Katamine, Takuya Hashimoto, Junya Ako   +6 more
doaj   +1 more source

Ligation of macrophage Fcγ receptors recapitulates the gene expression pattern of vulnerable human carotid plaques. [PDF]

PLoS ONE, 2011
Stroke is a leading cause of death in the United States. As ∼60% of strokes result from carotid plaque rupture, elucidating the mechanisms that underlie vulnerability is critical for therapeutic intervention.
Michelle R Lennartz, Ankur Aggarwal, Tanya M Michaud, Paul J Feustel, David M Jones, M Julia Brosnan, Rebecca S Keller, Daniel J Loegering, Paul B Kreienberg   +8 more
doaj   +1 more source

Optical Coherence Tomography Vulnerable Plaque Segmentation Based on Deep Residual U-Net.

Reviews in cardiovascular medicine, 2019
Automatic and accurate segmentation of intravascular optical coherence tomography imagery is of great importance in computer-aided diagnosis and in treatment of cardiovascular diseases.
Lincan Li, Tong Jia
semanticscholar   +1 more source

NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK/PI3K/AKT pathway

Redox Biology, 2023
NADPH oxidases 2 (NOX2) is the main source of ROS in macrophages, which plays a critical role in the formation of atherosclerosis. However, effects of NOX2 inhibition on established vulnerable plaques and the potential role involved remain unclear.
Yue Wang, Xin-yan Liu, Yue Wang, Wen-xin Zhao, Fa-dong Li, Peng-rong Guo, Qian Fan, Xiao-fan Wu   +7 more
doaj   +1 more source

Personalized Assessment of the Coronary Atherosclerotic Arteries by Intravascular Ultrasound Imaging: Hunting the Vulnerable Plaque

Journal of Personalized Medicine, 2019
The term “vulnerable plaque” is commonly used to refer to an atherosclerotic plaque that is prone to rupture and the formation of thrombosis, which can lead to several cardiovascular and cerebrovascular events.
T. Papaioannou, C. Kalantzis, E. Katsianos, D. Sanoudou, M. Vavuranakis, D. Tousoulis   +5 more
semanticscholar   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Imaging Atherosclerosis and Vulnerable Plaque [PDF]

Journal of Nuclear Medicine, 2010
Identifying patients at high risk for an acute cardiovascular event such as myocardial infarction or stroke and assessing the total atherosclerotic burden are clinically important. Currently available imaging modalities can delineate vascular wall anatomy and, with novel probes, target biologic processes important in plaque evolution and plaque ...
Mehran M, Sadeghi, David K, Glover, Gregory M, Lanza, Zahi A, Fayad, Lynne L, Johnson   +4 more
openaire   +2 more sources

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

ASSESSMENT OF ATHEROSCLEROTIC PLAQUE VULNERABILITY OF CORONARY ARTERIES IN CASES OF SUDDEN CARDIAC DEATH

Pakistan Armed Forces Medical Journal, 2010
Objective: To study the plaque vulnerability in coronary arteries taken from autopsy specimens, of individuals dying of ischemic heart disease in our setup and to compare it with atheroma of those who died of non-cardiac causes.
Brig Shahid Jamal, Salma Naz, Azhar Mubarik, Tariq Masood Malik, Alia Zubair   +4 more
doaj   +2 more sources