Results 211 to 220 of about 1,043,722 (370)

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

open access: yesAdvanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen   +11 more
wiley   +1 more source

Vulnerable mobile populations overlooked

open access: yesForced Migration Review, 2010
Many countries have been seemingly overwhelmed by the speed with which the HIV epidemic has spread and its impact on forced migrants and other mobile populations.
Leo Kenny   +2 more
doaj  

MIGRATORY CONNECTIVITY AND RATE OF POPULATION DECLINE IN A VULNERABLE SONGBIRD [PDF]

open access: bronze, 2008
Jason Jones   +5 more
openalex   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

open access: yesAdvanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai   +14 more
wiley   +1 more source

Adapting Psychiatric Approaches to the Needs of Vulnerable Populations: A Qualitative Analysis. [PDF]

open access: yesEur J Investig Health Psychol Educ
Besson P   +3 more
europepmc   +1 more source

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