Results 41 to 50 of about 1,043,722 (370)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
A Climate Change Vulnerability Assessment Framework: A Spatial Approach [PDF]
arXiv, 2021 Climate change is affecting every known society, especially for small farmers in Low-Income Countries because they depend heavily on rain, seasonality patterns, and known temperature ranges. To build climate change resilient communities among rural farmers, the first step is to understand the impact of climate change on the population.
arxiv
Montefiore Medical Center: Integrated Care Delivery for Vulnerable Populations [PDF]
, 2010 Describes a system of hospitals and community- and school-based clinics tailored to low-income patients through systemwide strategies, high-quality specialty and hospital care, and integrated care delivery via care management and information ...
Deborah Chase
core
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
A scoping review of social determinants of health curricula in post-graduate medical education
Canadian Medical Education Journal, 2019 Social determinants of health are responsible for 50% of ill health. The Royal College of Physicians and Surgeons of Canada CanMEDS role of “physician advocate” requires physicians to attain competency in this particular domain, but physician trainees ...
Kimberly Anne Hunter, Ben Thomson
doaj +1 more source
Layers of Limbo: Governing Vulnerable & Displaced Populations in Thailand [PDF]
, 2013 In Thailand, the international community is confronted by one of the most protracted and complicated migration crises in the world. By examining this complex issue from the vantage point of a variety of stakeholders – the Royal Thai Government (RTG ...
Christiansen, Morgan +4 more
core +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Human Activity and Mobility Data Reveal Disparities in Exposure Risk Reduction Indicators among Socially Vulnerable Populations during COVID-19 [PDF]
arXiv, 2021 Non-pharmacologic interventions (NPIs) are one method to mitigate the spread and effects of the COVID-19 pandemic in the United States. NPIs promote protective actions to reduce exposure risk and can reduce mobility patterns within communities. Growing research literature suggests that socially vulnerable populations are disproportionately impacted ...
arxiv
Understanding Vulnerable Populations [PDF]
, 2021 Human mobility, in its different manifestations — international and domestic migration; refugees, asylum seekers, and displaced populations; and human trafficking — is at the center of many political and public debates.
Caldwell, Dakota
core +1 more source
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source