Results 61 to 70 of about 434,617 (300)

mHealth app using machine learning to increase physical activity in diabetes and depression: clinical trial protocol for the DIAMANTE Study

BMJ Open, 2020
Introduction Depression and diabetes are highly disabling diseases with a high prevalence and high rate of comorbidity, particularly in low-income ethnic minority patients.
Urmimala Sarkar, Jing Xu, Bibhas Chakraborty, Adrian Aguilera, Caroline A Figueroa, Rosa Hernandez-Ramos, Anupama Cemballi, Laura Gomez-Pathak, Jose Miramontes, Elad Yom-Tov, Xiaoxi Yan, Arghavan Modiri, Jai Aggarwal, Joseph Jay Williams, Courtney R Lyles   +14 more
doaj   +1 more source

Emergency preparedness for vulnerable populations

, 2023
This paper seeks to understand the current relationship between emergency preparedness and vulnerable populations. Vulnerable populations refer to individuals with physical, cognitive, or sensory disadvantages as well as individuals in low-income housing/

core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Utilization of the Behavior Change Wheel framework to develop a model to improve cardiometabolic screening for people with severe mental illness

Implementation Science, 2017
Background Individuals with severe mental illness (e.g., schizophrenia, bipolar disorder) die 10–25 years earlier than the general population, primarily from premature cardiovascular disease (CVD).
Christina Mangurian, Grace C. Niu, Dean Schillinger, John W. Newcomer, James Dilley, Margaret A. Handley   +5 more
doaj   +1 more source

Working with vulnerable populations

, 2015
We discuss key issues to consider when conducting clinical trials with vulnerable children, youths, and families, with particular attention to groups affected by communal violence/war and families affected by HIV/AIDS.
Fredrick Kanyanganzi, Catherine Kirk, Moses Zombo, Morris Munyana, Katrina Hann, Theresa S. Betancourt, Christine Mushashi, William Beardslee, Justin I. Bizimana   +8 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Identifying and Mapping Vulnerable Populations

, 2018
Climate change does not affect all populations uniformly; there are disproportionate impacts on certain populations who are more vulnerable to displacement, injury or death due to risk factors such as poverty, race, age, and medical conditions.

core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Impact of incarceration on cardiovascular disease risk factors: a systematic review and meta-regression on weight and BMI change

BMJ Open, 2020
Objective Cardiovascular disease is an underappreciated issue in prison medicine. Recent studies have revealed a higher prevalence of cardiovascular disease risk factors (CVDRFs) among individuals in prison, but the impact of incarceration on CVDRFs over
Patrick Bodenmann, Constantin Bondolfi, Patrick Taffe, Aurélie Augsburger, Cécile Jaques, Mary Malebranche, Carole Clair   +6 more
doaj   +1 more source