Results 61 to 70 of about 2,628,839 (264)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Identifying and Mapping Vulnerable Populations
, 2018 Climate change does not affect all populations uniformly; there are disproportionate impacts on certain populations who are more vulnerable to displacement, injury or death due to risk factors such as poverty, race, age, and medical conditions.
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Effects of introduced trout predation on non-diadromous galaxiid fish populations across invaded riverscapes [PDF]
, 2013 We assessed the landscape-scale effect of predation pressure from trout on the population integrity and distributions of non-diadromous galaxiids in high-country streams of the South Island, New Zealand.
Darragh J. Woodford, Angus R. McIntosh
core
Global Impact of COVID -19 on Service Delivery and Vulnerable Populations' Access to Dental Care [PDF]
, 2020 The aim of this paper is to provide an overview of the global impact of COVID-19 on dental professionals as well as highlight the barriers and challenges of global access to oral health care during the pandemic, especially among vulnerable ...
Ramos-Gomez, Francesco +6 more
core
BMJ Open, 2020 Objective Cardiovascular disease is an underappreciated issue in prison medicine. Recent studies have revealed a higher prevalence of cardiovascular disease risk factors (CVDRFs) among individuals in prison, but the impact of incarceration on CVDRFs over
Patrick Bodenmann +6 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The Scientific World JournalChronic wounds, especially in diabetic patients, are difficult to manage because of delayed healing and high infection risk. Traditional polyherbal formulations, which are composed of multiple medicinal plants with synergistic effects, are widely used in
Samuel Abiodun Kehinde +4 more
doaj +1 more source
SAHARA-J, 2008 This exploratory study examines the links between drug use and high-risk sexual practices and HIV in vulnerable drug-using populations in South Africa, including commercial sex workers (CSWs), men who have sex with men (MSM), injecting drug users (IDUs ...
Charles Parry +4 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source