Results 71 to 80 of about 434,617 (300)

Editorial : clinical cancer research in vulnerable populations

, 2023
Vulnerable populations in cancer care include a wide array of possible conditions (see Table 1). Their vulnerabilities, whether medical, sociocultural, age- or socioeconomic-related, cause these cancer populations to be excluded from clinical trials ...
Schofield, Patricia, Parris, Christopher N., Debruyne, Philip R., Boterberg, Tom, Tack, Laura   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Rapid assessment of drug use and sexual HIV risk patterns among vulnerable drugusing populations in Cape Town, Durban and Pretoria, South Africa

SAHARA-J, 2008
This exploratory study examines the links between drug use and high-risk sexual practices and HIV in vulnerable drug-using populations in South Africa, including commercial sex workers (CSWs), men who have sex with men (MSM), injecting drug users (IDUs ...
Charles Parry, Petal Petersen, Tara Carney, Sarah Dewing, Richard Needle   +4 more
doaj   +1 more source

Development of a Frailty Framework Among Vulnerable Populations [PDF]

, 2014
Frailty is a public health issue that is experienced by homeless and other vulnerable populations; to date, a frailty framework has not been proposed to guide researchers who study hard-to-reach populations.
Nyamathi, Adeline, Brecht, Mary-Lynn, Phillips, Linda R, Mentes, Janet C, Sarkisian, Catherine, Salem, Benissa E   +5 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Complementary medicine among individuals experiencing homelessness in Switzerland: a quantitative and qualitative descriptive study

BMC Complementary Medicine and Therapies
Background People experiencing homelessness (PEH) are disproportionately affected by health issues yet remain underserved by the health care system. Emerging findings suggest that complementary medicine (CM) approaches might help address the low access ...
Véronique S. Grazioli, Evelyne Hangartner, Patrick Bodenmann, Luana Schaad, Léa Grosjean, Justin Nikles, David J. T. Campbell, Laurent Hyvert, Tshahé Anongba Varela, Susan E. Collins, Caroline Leblanc, Christine Loignon, Chantal Berna   +12 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Clinical Effectiveness of Traditional Polyherbal Formulations for Wound Healing: A Systematic Review and Meta-Analysis

The Scientific World Journal
Chronic wounds, especially in diabetic patients, are difficult to manage because of delayed healing and high infection risk. Traditional polyherbal formulations, which are composed of multiple medicinal plants with synergistic effects, are widely used in
Samuel Abiodun Kehinde, Nurulhusna Awaeloh, Pinanong Na-Phatthalung, Siriwan Kantisin, Sasitorn Chusri   +4 more
doaj   +1 more source

An Efficient Gatekeeper Algorithm for Detecting GxE

Cancer Informatics, 2010
The risk for many complex diseases is believed to be a result of the interactive effects of genetic and environmental factors. Developing efficient techniques to identify gene-environment interactions (GxE) is important for unraveling the etiologic basis
Jimmy T. Efird
doaj   +1 more source

Effects of introduced trout predation on non-diadromous galaxiid fish populations across invaded riverscapes [PDF]

, 2013
We assessed the landscape-scale effect of predation pressure from trout on the population integrity and distributions of non-diadromous galaxiids in high-country streams of the South Island, New Zealand.
Darragh J. Woodford, Angus R. McIntosh
core