Results 111 to 120 of about 60,545 (283)

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

IL-6 Released from Hepatic Stellate Cells Promotes Glycolysis and Migration of HCC Through the JAK1/vWF/TGFB1 Axis

Journal of Hepatocellular Carcinoma
Yifei Zhu,1,* Jiayi Gu,1,* Yuxin Lu,1 Qianying Tao,1 Xinliang Cao,1 Yanqing Zhu,1 Mu-qing Yang,2 Xin Liang1 1Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of ...
Zhu Y, Gu J, Lu Y, Tao Q, Cao X, Zhu Y, Yang MQ, Liang X   +7 more
doaj  

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Scheme for measurement of active VWF.

, 2019
(A) The protein domain structure of mature VWF (adapted from Crawley et al.[27]). (B) The set-up of the immunosorbent assay described here, based on a variable heavy chain antibody fragment (VHH) directed against a cryptic epitope in the A1 domain of VWF
Jasper A. Remijn (6331226), Hilde Kelchtermans (12561), Philip G. de Groot (167182), Lisa N. van der Vorm (6331220), Dana Huskens (211452), Walid Chayouâ (6331223), Bas de Laat (339246), Li Li (14993), Mark Roest (377867)   +8 more
core   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Biomarkers of Prothrombotic State and Risk Assessment of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease

International Journal of COPD
Yan Jin,1,2,* Ke Zhu,1,* Shiyu Wu,1 Shiyi He,1 Chao Cao1 1Department of Respiratory and Critical Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, People’s Republic of China ...
Jin Y, Zhu K, Wu S, He S, Cao C
doaj  

Development of mass spectrometry methods for the identification and quantification of pro-thrombotic oxidative modifications of von Willebrand factor

reservedIl fattore di von Willebrand (vWF) è una proteina plasmatica multimerica ad alto peso molecolare essenziale per l’emostasi primaria. I suoi multimeri ultra-large sono particolarmente trombogenici.
REGINATO, DENISE
core  

Analytical characteristics of the active VWF assay.

, 2019
(A) Binding of the VHH to R1306W VWF (●), R1306Q VWF (○), HVWF (σ), VWF in NPP under static conditions (π) and NPP after vortexing to simulate shear stress (▪, only 10x diluted). Dilution factors are indicated at the x-axis. (B) Mean active VWF levels in
Jasper A. Remijn (6331226), Hilde Kelchtermans (12561), Philip G. de Groot (167182), Lisa N. van der Vorm (6331220), Dana Huskens (211452), Walid Chayouâ (6331223), Bas de Laat (339246), Li Li (14993), Mark Roest (377867)   +8 more
core   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Mean plasma and platelet VWF in patients with quantitative (upper panel) and functional (lower panel) VWF defects.

, 2016
Type 1 VWD patients were divided into severe and mild cases, based on their circulating VWF levels (< 10U/dL and < 50 U/dL, respectively). Mild type 1 patients were further grouped according to their normal or low platelet VWF content.
Elena Pontara (584553), Maria Grazia Cattini (2993664), Alessandra Casonato (584552), Viviana Daidone (2993667), Antonella Bertomoro (584551), Paolo Prandoni (2993661)   +5 more
core   +1 more source