Results 101 to 110 of about 80,049 (294)
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
, 2018 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P. +6 more
core +4 more sources
Food Safety and Health, EarlyView.A conceptual framework of virtual water showing its sources, major applications, components of the virtual water footprint, and emerging future directions. The diagram emphasizes the growing role of virtual water in global sustainability and resource planning.
Priti Bhowmik +2 more
wiley +1 more source
Haematologica, 2010 Background Type 2B von Willebrand factor (VWF) is characterized by gain of function mutations in the A1 domain inducing a greater affinity for platelet GPIb, possibly associated with the disappearance of large VWF multimers and thrombocytopenia.Design ...
Alessandra Casonato +7 more
doaj +1 more source
Clinical Features And Laboratory Patterns In A Cohort Of Consecutive Argentinian Patients With Von Willebrand's Disease [PDF]
, 2001 Background and Objectives. von Willebrand's disease (vWD) is a bleeding disorder with variable clinical expression. Our aim was to classify patients with vWD and to determine the phenotype in their relatives. Design and Methods.
Blanco, A. N. +6 more
core
The Journal of Cell Biology, 2006 ![Graphic][1] Extended organelle form (left) is needed for later correct function. CUTLER/ELSEVIERFollowing blood vessel injury, long strings of multimeric von Willebrand's factor (VWF) act as a scaffold for platelets to help staunch bleeding. The VWF strings, 100-μm long or more,
openaire +1 more source
International Journal of Cancer, EarlyView.Although immune checkpoint inhibitors (ICI) have transformed metastatic melanoma treatment, thromboembolic events (TEEs) remain a serious complication. Moreover, existing risk assessment models were developed prior to ICI use and lack clinical validation.
Tim Zell +12 more
wiley +1 more source
Von Willebrand Factor and ADAMTS13 in COVID-19 and Beyond: A Question of Balance
European Medical Journal Nephrology, 2021 von Willebrand factor (VWF) is a large, adhesive, multimeric protein involved in haemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein. A deficiency or defect in VWF can lead to von Willebrand disease
Emmanuel J Favaloro +2 more
doaj
Autosomal dominant C1149R von Willebrand disease: phenotypic findings and their implications
Haematologica, 2009 Background Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD).Design and Methods Eight patients from three unrelated families with this mutation were included in
Almudena Pérez-Rodríguez +5 more
doaj +1 more source
Animal Conservation, EarlyView.Captive populations of threatened species risk losing genetic diversity over time. We evaluated the genetic status of contemporary captive western lowland gorillas (Gorilla gorilla gorilla) at Howletts and Port Lympne and compared this with specimens from a historical wild population.
Jaimie Morris +5 more
wiley +1 more source
Hemostasis biomarkers and incident cognitive impairment: the REGARDS study [PDF]
, 2018 Essentials Cognitive disorders are increasing and vascular risk factors play a role in this. We performed a nested case control study of hemostasis biomarkers and cognitive impairment (CI). Higher baseline fibrinogen, factor VIII and D-dimer were related
Callas, P.W. +7 more
core +1 more source