Results 101 to 110 of about 60,545 (283)

Excessive cleavage of von Willebrand factor multimers by ADAMTS13 may predict the progression of transplant-associated thrombotic microangiopathy

Research and Practice in Thrombosis and Haemostasis
Background: Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication of hematopoietic stem cell transplantation and is characterized by severe thrombocytopenia, hemolytic anemia, and organ dysfunction.
Shinya Yamada, Kazuya Sakai, Masayuki Kubo, Hirokazu Okumura, Hidesaku Asakura, Toshihiro Miyamoto, Masanori Matsumoto   +6 more
doaj   +1 more source

vWF sequences

, 2016
Nexus file containing phased alleles from vWF sequences of Sunda shelf Crocidura.
Handika, Heru, Demos, Terrence C., Thomas C. Giarla (3199704), Maharadatunkamsi (3199695), Heru Handika (3199701), Kevin C. Rowe (223136), Terrence C. Demos (798528), Jacob A. Esselstyn (214666), Rowe, Kevin C., Anang S. Achmadi (3199698), Giarla, Thomas C., Esselstyn, Jacob A., Maharadatunkamsi, Achmadi, Anang S.   +13 more
core   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Deficiency of high‐molecular‐weight von Willebrand factor mitigates thrombo‐complement injury in an LPS‐induced TMA‐like mouse model

VIEW, EarlyView.
Reduction of high‐molecular‐weight von Willebrand factor disrupts the platelet–complement amplification loop, attenuating microvascular thrombosis, complement deposition, endothelial injury, and organ damage in complement‐mediated thrombotic microangiopathy.
Yang Li, Chihao Zhang, Xiaoqian Xu, Sicong Wang, Xiaofan Hu, Junjie Yao, Xi Wu, Difeng Zhu, Qian Liang, Yeling Lu, Yu Liu, Guanqun Xu, Jiakuan Zhou, Qiulan Ding, Wenman Wu, Ya Li, Jing Dai, Xuefeng Wang   +17 more
wiley   +1 more source

Heart Rate Variability Features as Predictors of Intermittent Theta‐Burst Stimulation Response in Posttraumatic Stress Disorder

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Background Posttraumatic stress disorder (PTSD) is associated with autonomic dysfunction as indicated by deficits in the sympathetic and parasympathetic nervous systems. These abnormalities are expressed as elevated heart rate and reduced heart rate variability (HRV), respectively.
Camila Cosmo, Antonia V. Seligowski, Emily M. Aiken, Mascha van't Wout‐Frank, Noah S. Philip   +4 more
wiley   +1 more source

GrM does not affect VWF multimerization.

, 2013
Purified plasma VWF (2 µg/mL) was incubated with indicated concentrations of GrM, GrB, GrM-SA and GrB-SA in Tris (pH 7.4) for 1 hour at 37°C. (A) Samples analyzed at 6% SDS-PAGE and Western blot, using an antibody against VWF. Mature VWF and VWF cleavage
Martine J. Hollestelle (345019), Philip G. de Groot (167182), Tom Sprong (278692), Peter J. Lenting (133252), Niels Bovenschen (345021), Ka Wai Lai (345020), Marcel van Deuren (15650)   +6 more
core   +1 more source

Genotyping Contemporary Captive and Historical Wild Western Lowland Gorillas Indicates Captive Breeding Is Maintaining Genetic Diversity in a Critically Endangered Primate

Animal Conservation, EarlyView.
Captive populations of threatened species risk losing genetic diversity over time. We evaluated the genetic status of contemporary captive western lowland gorillas (Gorilla gorilla gorilla) at Howletts and Port Lympne and compared this with specimens from a historical wild population.
Jaimie Morris, Tony King, John Hills, Simon C. Harvey, Jane Hopper, Rodrigo Vega   +5 more
wiley   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Challenges and considerations of genetic testing in von Willebrand disease

Research and Practice in Thrombosis and Haemostasis
von Willebrand disease (VWD) is the most common inherited bleeding disorder characterized by defects in the quantity or function of the von Willebrand factor (VWF).
Omid Seidizadeh, Luciano Baronciani, Flora Peyvandi   +2 more
doaj   +1 more source