Results 91 to 100 of about 56,101 (281)
Von Willebrand Factor and ADAMTS13 in COVID-19 and Beyond: A Question of Balance
European Medical Journal Nephrology, 2021 von Willebrand factor (VWF) is a large, adhesive, multimeric protein involved in haemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein. A deficiency or defect in VWF can lead to von Willebrand disease
Emmanuel J Favaloro +2 more
doaj
Autosomal dominant C1149R von Willebrand disease: phenotypic findings and their implications
Haematologica, 2009 Background Mutation C1149R in the von Willebrand factor (VWF) gene has been thought to cause autosomal dominant severe type 1 von Willebrand disease (VWD).Design and Methods Eight patients from three unrelated families with this mutation were included in
Almudena Pérez-Rodríguez +5 more
doaj +1 more source
GrM does not affect VWF multimerization.
, 2013 Purified plasma VWF (2 µg/mL) was incubated with indicated concentrations of GrM, GrB, GrM-SA and GrB-SA in Tris (pH 7.4) for 1 hour at 37°C. (A) Samples analyzed at 6% SDS-PAGE and Western blot, using an antibody against VWF. Mature VWF and VWF cleavage
Martine J. Hollestelle (345019) +6 more
core +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib +8 more
wiley +1 more source
O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies. [PDF]
Von Willebrand factor (VWF) undergoes complex post-translational modification within endothelial cells (EC) prior to secretion. This includes significant N- and O-linked glycosylation.
Petra E Bürgisser (18770413) +7 more
core +2 more sources
, 2013 Nexus file containing phased alleles from vWF sequences of Javan Crocidura.
Jacob A. Esselstyn (214666) +9 more
core +1 more source
Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration
BMEMat, EarlyView.The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang +13 more
wiley +1 more source
Haematologica, 2010 Background Type 2B von Willebrand factor (VWF) is characterized by gain of function mutations in the A1 domain inducing a greater affinity for platelet GPIb, possibly associated with the disappearance of large VWF multimers and thrombocytopenia.Design ...
Alessandra Casonato +7 more
doaj +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia +2 more
wiley +1 more source
Analytical characteristics of the active VWF assay.
, 2019 (A) Binding of the VHH to R1306W VWF (●), R1306Q VWF (○), HVWF (σ), VWF in NPP under static conditions (π) and NPP after vortexing to simulate shear stress (▪, only 10x diluted). Dilution factors are indicated at the x-axis. (B) Mean active VWF levels in
Jasper A. Remijn (6331226) +8 more
core +1 more source