Results 71 to 80 of about 56,156 (204)

Molecular Mechanisms of vWF Secretion [PDF]

, 2014
von Willebrand factor (vWF) secreted by endothelial cells (EC) is essential for hemostasis and thrombosis. However the molecular mechanism of vWF secretion is poorly understood.
Luiza Rusu (7973144)
core  

Mean plasma and platelet VWF in patients with quantitative (upper panel) and functional (lower panel) VWF defects. [PDF]

, 2016
Type 1 VWD patients were divided into severe and mild cases, based on their circulating VWF levels (< 10U/dL and < 50 U/dL, respectively). Mild type 1 patients were further grouped according to their normal or low platelet VWF content.
Elena Pontara (584553), Maria Grazia Cattini (2993664), Alessandra Casonato (584552), Viviana Daidone (2993667), Antonella Bertomoro (584551), Paolo Prandoni (2993661)   +5 more
core   +1 more source

Von Willebrand disease type Vicenza: In search of a classification for the archetype of reduced von Willebrand factor survival

eJHaem, 2021
Type Vicenza von Willebrand disease (VWD) features a von Willebrand factor (VWF) with a very short half‐life, and is classified as a form of type 1 VWD. To test the appropriateness of type Vicenza VWD classification, the main features of 17 patients from
Alessandra Casonato, Eva Galletta, Federico Galvanin, Viviana Daidone   +3 more
doaj   +1 more source

Scheme for measurement of active VWF. [PDF]

, 2019
(A) The protein domain structure of mature VWF (adapted from Crawley et al.[27]). (B) The set-up of the immunosorbent assay described here, based on a variable heavy chain antibody fragment (VHH) directed against a cryptic epitope in the A1 domain of VWF
Jasper A. Remijn (6331226), Hilde Kelchtermans (12561), Philip G. de Groot (167182), Lisa N. van der Vorm (6331220), Dana Huskens (211452), Walid Chayouâ (6331223), Bas de Laat (339246), Li Li (14993), Mark Roest (377867)   +8 more
core   +1 more source

Analytical characterization and reference interval of an enzyme-linked immunosorbent assay for active von Willebrand factor.

PLoS ONE, 2019
BackgroundInteraction of von Willebrand factor (VWF) with platelets requires a conformational change that exposes an epitope within the VWF A1 domain, enabling platelet glycoprotein Ibα binding.
Lisa N van der Vorm, Li Li, Dana Huskens, Walid Chayouâ, Hilde Kelchtermans, Philip G de Groot, Mark Roest, Jasper A Remijn, Bas de Laat   +8 more
doaj   +1 more source

Clinical phenotype and pathophysiological mechanisms underlying qualitative Low VWF [PDF]

Previous reports have highlighted that some patients with low von Willebrand factor (VWF) with significant bleeding were diagnosed based on an isolated but persistent reduction in plasma VWF activity levels in the 30 to 50 IU/dL range. These patients had
Doyle, Mairead, van Galen, Karin P M, Schols, Saskia E M, Preston, Roger J S, van Kwawegen, Calvin B., Cnossen, Marjon H., Heubel-Moenen, Floor C J I, Baker, Ross I., van der Bom, Johanna G, Eikenboom, Jeroen C J, Leebeek, Frank W G, Heubel-Moenen, Floor C.J.I., van Heerde, Waander L, James, Paula, Doyle, Mairead M, Di Paola, Jorge, van Kwawegen, Calvin, O'Donnell, James S, Schols, Saskia E.M., O'Connell, Niamh M, Cnossen, Marjon H, James, Paula D, van der Bom, Johanna G., Meijer, Karina; id_orcid, Fijnvandraat, Karin, Atiq, Ferdows, Preston, Roger J.S., O'Donnell, James S., Doherty, Dearbhla, Baker, Ross Ian, Blok, Robin, de Meris, Joke, Hulshof, Anne-Marije, Byrne, Mary B, Hulshof, Anne Marije, Leebeek, Frank W.G.; id_orcid, Meijer, Karina, O'Connell, Niamh M., van Galen, Karin P.M., Leebeek, Frank W.G., Byrne, Mary, Lavin, Michelle, Eikenboom, Jeroen, Ryan, Kevin, van Heerde, Waander L.   +44 more
core   +4 more sources

Figure 5: Immunohistologic Staining for vWF [PDF]

, 2019
Representative micrograph images of von Willebrand factor (vWF) immunohistochemistry staining on cross sections of silk grafts at 3 (A), 6 (B), 12 (C), and 24 (D) weeks. vWF staining is red, and 4′,6-diamidino-2-phenylindole staining is blue. Scale bar =
Nianji Yang (6821876), Jelena Rnjak-Kovacina (1356204), Elysse C. Filipe (761411), Juichien Hung (2590255), Alex H.P. Chan (4786665), Martin K.C. Ng (6820748), Steven G. Wise (761405), Bob S.L. Lee (4786662), Miguel Santos (748732)   +8 more
core   +1 more source

Comparative assessment of changes ADAMTS-13/von Willebrand factor axis in singleton and bichorial biamniotic pregnancy

Акушерство, гинекология и репродукция
Aim: to compare changes in the ADAMTS-13 metalloproteinase/von Willebrand factor (vWF) axis in pregnant women with spontaneous or following in vitro fertilization (IVF) singleton and bichorial biamniotic pregnancies.Materials and Methods.
F. Е. Yagubova, V. O. Bitsadze, N. V. Samburova, J. Kh. Khizroeva, A. D. Makatsariya   +4 more
doaj   +1 more source

Assay of von Willebrand Factor (vWF)-cleaving Protease Based on Decreased Collagen Binding Affinity of Degraded vWF [PDF]

, 1999
SummaryPatients with thrombotic thrombocytopenic purpura (TTP) have a deficiency of von Willebrand factor (vWF)-cleaving protease, whereas patients with hemolytic-uremic syndrome (HUS) show normal activity of this protease.
Bernhard Lämmle, Miha Furlan, Peter Turecek, Hans Schwarz, Helena Gerritsen   +4 more
core   +1 more source

External genital endometriosis post-surgery hemostasis parameters

Акушерство, гинекология и репродукция
Introduction. Endometriosis is one of the common diseases with poorly elucidated underlying nature and pathogenetic mechanisms. Clinical trials suggest that women suffering from it have hemostasis disorders.
B. Baigalmaa, V. O. Bitsadze, A. G. Solopova, A. E. Efanov, A. Е. Voynovskiy   +4 more
doaj   +1 more source