Results 71 to 80 of about 56,101 (281)

The interaction between factor H and Von Willebrand factor. [PDF]

PLoS ONE, 2013
Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS).
Shuju Feng, Xiaowen Liang, Miguel A Cruz, Hangoc Vu, Zhou Zhou, Naresh Pemmaraju, Jing-Fei Dong, Michael H Kroll, Vahid Afshar-Kharghan   +8 more
doaj   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

External genital endometriosis post-surgery hemostasis parameters

Акушерство, гинекология и репродукция
Introduction. Endometriosis is one of the common diseases with poorly elucidated underlying nature and pathogenetic mechanisms. Clinical trials suggest that women suffering from it have hemostasis disorders.
B. Baigalmaa, V. O. Bitsadze, A. G. Solopova, A. E. Efanov, A. Е. Voynovskiy   +4 more
doaj   +1 more source

Summary of 8 mAbs to VWF and their effects on VWF proteolysis by ADAMTS13.

, 2013
Summary of 8 mAbs to VWF and their effects on VWF proteolysis by ADAMTS13.
Ningzheng Dong (328283), Changgeng Ruan (328282), Jingyu Zhang (256203), Yiming Zhao (348349), Zhenni Ma (328280), Jian Su (86223), Anyou Wang (281729), Fang Liu (13271), Fei Shen (348351)   +8 more
core   +1 more source

Clinical phenotype and pathophysiological mechanisms underlying qualitative Low VWF [PDF]

Previous reports have highlighted that some patients with low von Willebrand factor (VWF) with significant bleeding were diagnosed based on an isolated but persistent reduction in plasma VWF activity levels in the 30 to 50 IU/dL range. These patients had
Doyle, Mairead, van Galen, Karin P M, Schols, Saskia E M, Preston, Roger J S, van Kwawegen, Calvin B., Cnossen, Marjon H., Heubel-Moenen, Floor C J I, Baker, Ross I., van der Bom, Johanna G, Eikenboom, Jeroen C J, Leebeek, Frank W G, Heubel-Moenen, Floor C.J.I., van Heerde, Waander L, James, Paula, Doyle, Mairead M, Di Paola, Jorge, van Kwawegen, Calvin, O'Donnell, James S, Schols, Saskia E.M., O'Connell, Niamh M, Cnossen, Marjon H, James, Paula D, van der Bom, Johanna G., Meijer, Karina; id_orcid, Fijnvandraat, Karin, Atiq, Ferdows, Preston, Roger J.S., O'Donnell, James S., Doherty, Dearbhla, Baker, Ross Ian, Blok, Robin, de Meris, Joke, Hulshof, Anne-Marije, Byrne, Mary B, Hulshof, Anne Marije, Leebeek, Frank W.G.; id_orcid, Meijer, Karina, O'Connell, Niamh M., van Galen, Karin P.M., Leebeek, Frank W.G., Byrne, Mary, Lavin, Michelle, Eikenboom, Jeroen, Ryan, Kevin, van Heerde, Waander L.   +44 more
core   +2 more sources

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome

American Journal of Hematology, EarlyView.
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source

Hemodynamic activation of von Willebrand factor in children with congenital heart diseases

Акушерство, гинекология и репродукция
Quite complex and non-linear cellular and molecular mechanisms underlie hemostasis changes in patients with congenital heart diseases (CHD). Altered activity ratio between von Willebrand factor (vWF) and metalloproteinase ADAMTS-13 (a disintegrin and ...
K. A. Tokmakova, D. N. Shilkin, A. A. Kupryashov   +2 more
doaj   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects.

PLoS ONE, 2015
ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII activity,
Jaewoo Song, Fengju Chen, Marco Campos, Doug Bolgiano, Katie Houck, Lloyd E Chambless, Kenneth K Wu, Aaron R Folsom, David Couper, Eric Boerwinkle, Jing-fei Dong   +10 more
doaj   +1 more source

Binding of recombinant full-length and truncated fH molecules to VWF and VWF-A2.

, 2013
(A) Recombinant GST VWF-A2 protein (100 nM) was mixed with recombinant full-length or truncated fH (30 nM) and precipitated using glutathione agarose beads.
Vahid Afshar-Kharghan (450560), Michael H. Kroll (450559), Jing-Fei Dong (450558), Miguel A. Cruz (368558), Naresh Pemmaraju (450557), Hangoc Vu (450556), Shuju Feng (450555), Xiaowen Liang (373131), Zhou Zhou (154603)   +8 more
core   +1 more source