Results 81 to 90 of about 56,156 (204)

Regulated von Willebrand factor (vWf) secretion is restored by pro-vWf expression in a transfectable endothelial cell line [PDF]

, 2000
Von Willebrand factor (vWf) is a glycoprotein involved in primary hemostasis and synthesized in endothelial cells (EC). vWf is stored in secretory granules specific for EC called Weibel–Palade bodies (WPb).
Ribba, A.-S., Kruithof, E.K.O., Rosnoblet, C., Wollheim, C.B., Vischer, U.M.   +4 more
core   +1 more source

Hemodynamic activation of von Willebrand factor in children with congenital heart diseases

Акушерство, гинекология и репродукция
Quite complex and non-linear cellular and molecular mechanisms underlie hemostasis changes in patients with congenital heart diseases (CHD). Altered activity ratio between von Willebrand factor (vWF) and metalloproteinase ADAMTS-13 (a disintegrin and ...
K. A. Tokmakova, D. N. Shilkin, A. A. Kupryashov   +2 more
doaj   +1 more source

Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11,673 Subjects.

PLoS ONE, 2015
ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII activity,
Jaewoo Song, Fengju Chen, Marco Campos, Doug Bolgiano, Katie Houck, Lloyd E Chambless, Kenneth K Wu, Aaron R Folsom, David Couper, Eric Boerwinkle, Jing-fei Dong   +10 more
doaj   +1 more source

Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage

Blood, 2009
Abstract Human umbilical vein endothelial cell (HUVEC)–released ADAMTS-13 (a disintegrin and metalloprotease with thrombospondin repeats) and HUVEC-secreted von Willebrand factor (VWF) strings were investigated under static conditions that allow the accumulation and analysis of ADAMTS-13.
Nancy A, Turner, Leticia, Nolasco, Zaverio M, Ruggeri, Joel L, Moake   +3 more
openaire   +3 more sources

Maternal blood proteomics during relapse of early preeclampsia

Акушерство, гинекология и репродукция
Aim: to study the contribution of maternal blood endothelial proteins to developing relapse of early preeclampsia (ePE).Materials and Methods. A proteomic analysis of the peripheral blood of 137 pregnant women was performed. Clinically, three groups were
M. G. Nikolaeva, V. Yu. Terekhina, A. P. Momot   +2 more
doaj   +1 more source

Increased VWF-platelet binding and plasma VWF:Ag and active VWF levels in dengue patients. [PDF]

, 2019
(A) Platelet-VWF binding measured by flow cytometry in unstimulated samples (line is geometric mean with 95% confidence interval) and (B) after ex vivo stimulation with increasing concentrations of ristocetin in participants with acute dengue and healthy
Silvita Fitri Riswari (476299), Quirijn de Mast (167198), Gloria S. R. Utari (6439901), Nur Farhanah (6439904), Gijs J. Overheul (142176), Dirk J. Lefeber (190780), Bachti Alisjahbana (270243), Rolf T. Urbanus (502328), Vesla Kullaya (6439895), Rahajeng N. Tunjungputri (4451650), Philip. G. de Groot (6439907), M. Hussein Gasem (263447), Ronald P. van Rij (142192), Fadel M. Garishah (6439898), Andre van der Ven (103962)   +14 more
core   +1 more source

Development of mass spectrometry methods for the identification and quantification of pro-thrombotic oxidative modifications of von Willebrand factor [PDF]

reservedIl fattore di von Willebrand (vWF) è una proteina plasmatica multimerica ad alto peso molecolare essenziale per l’emostasi primaria. I suoi multimeri ultra-large sono particolarmente trombogenici.
REGINATO, DENISE
core  

O-glycan determinants regulate VWF trafficking to Weibel-Palade bodies. [PDF]

Von Willebrand factor (VWF) undergoes complex post-translational modification within endothelial cells (EC) prior to secretion. This includes significant N- and O-linked glycosylation.
Petra E Bürgisser (18770413), Ruben Bierings (159083), Dearbhla Doherty (10046030), James O'Donnell (7895615), Ellie Karampini (8712483), Stephanie Elliott (18770416), Massimiliano Garre (11051937), Ingmar Schoen (7895582)   +7 more
core   +4 more sources

Value of vWF-related indicators in the diagnosis of liver cirrhosis progression in patients with hepatitis B [PDF]

Zhenduanxue lilun yu shijian
Objective To evaluate the correlation between von Willebrand factor (vWF) and its related indicators and the progression of liver cirrhosis in patients with hepatitis B and explore the diagnostic value of vWF-related indicators in assisting the diagnosis
YANG Mingkang, LIU Yu, XU Guanqun, WANG Jianbiao, WANG Xuefeng, LIANG Qian
doaj   +1 more source

Von Willebrand Factor and ADAMTS13 in COVID-19 and Beyond: A Question of Balance

European Medical Journal Nephrology, 2021
von Willebrand factor (VWF) is a large, adhesive, multimeric protein involved in haemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein. A deficiency or defect in VWF can lead to von Willebrand disease
Emmanuel J Favaloro, Brandon Michael Henry, Giuseppe Lippi   +2 more
doaj