Key residues regulating von Willebrand factor A1/A2 interactions: insights from molecular dynamics simulations and experimental validation. [PDF]
Res Pract Thromb HaemostFang J +5 more
europepmc +1 more source
IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura
Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak +7 more
wiley +1 more source
Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice
Aging Cell, Volume 25, Issue 2, February 2026.Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy +9 more
wiley +1 more source
von Willebrand disease combined with other hemostasis disorders: an overlooked clinical entity. [PDF]
Res Pract Thromb HaemostSeidizadeh O, Mannucci PM, Peyvandi F.
europepmc +1 more source
A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System
Aging Cell, Volume 25, Issue 2, February 2026.Transcriptomic and cellular atlas of peripheral blood mononuclear cells (PBMCs) and stem and progenitor cells of the hematopoietic compartment (HSPCs) of aged C57Bl/6J mice. Analysis shows global alterations related to immune function and identifies potential pathways and cell populations that can be targeted for therapeutic intervention.
Ryan R. White +9 more
wiley +1 more source
Immune Thrombocytopenia and Type 1 von Willebrand Disease in a Patient With a Femoral Fracture: A Case Report. [PDF]
CureusFerreira A, Roberto A.
europepmc +1 more source
Landscape and Spectrum of VWF Variants in Type 2 Von Willebrand Disease: Insights from a German Patient Cohort [PDF]
Hamideh Yadegari +17 more
openalex +1 more source
Characterising the Periodontal Granulation Tissue Using scRNAseq
Journal of Clinical Periodontology, Volume 53, Issue 2, Page 308-320, February 2026.ABSTRACT Aim To investigate the cellular composition and molecular mechanisms of periodontal granulation tissue formation using single‐cell RNA sequencing (scRNA‐seq), aiming to enhance the understanding of periodontal disease pathogenesis and identify potential targets for regenerative therapies.
Wentao Zhu +7 more
wiley +1 more source