Results 281 to 290 of about 69,458 (313)

Endothelial function and vascular events in patients with limited cutaneous systemic sclerosis (EFVELSS): a prospective observational study. [PDF]

open access: yesRheumatol Int
Jud P   +19 more
europepmc   +1 more source
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Critical independent regions in the VWF propeptide and mature VWF that enable normal VWF storage

Blood, 2003
Von Willebrand factor (VWF) is synthesized in endothelial cells, where it is stored in Weibel-Palade bodies. Administration of 1-desamino-8-D-arginine-vasopressin (DDAVP) to patients with type 1 von Willebrand disease and to healthy individuals causes a rapid increase in plasma VWF levels.
Robert R. Montgomery   +2 more
openaire   +3 more sources

Uptake of vWF–Anti-vWF Complexes by Platelets in Suspension

Arteriosclerosis, Thrombosis, and Vascular Biology, 1996
Efforts to identify the translocation of glycoprotein (GP) Ib/IX receptors, either bound to von Willebrand factor (vWF) or not, from exposed surfaces to interior membranes of thrombin-activated platelets in suspension have been unsuccessful. To observe vWF uptake by platelets, we added an anti-vWF antibody and staphylococcal protein A–gold (to act as a
Marlys D. Krumwiede   +3 more
openaire   +3 more sources

Sequence Alignment between vWF and Peptides Inhibiting the vWF-collagen Interaction Does not Result in the Identification of a Collagen-binding Site in vWF

Thrombosis and Haemostasis, 2000
SummaryWe previously found that two peptides (N- and Q-peptide) selected by phage display for binding to an anti-vWF antibody, were able to inhibit vWF-binding to collagen (1). The sequence of those peptides could be aligned with the sequence in vWF at position 1129-1136 just outside the A3-domain.
Hans Deckmyn   +6 more
openaire   +4 more sources

The smaller, the better: VWF in stroke

Blood, 2010
In this issue of Blood , Fujioka and colleagues demonstrate that the von Willebrand factor–cleaving protease ADAMTS13 limits brain infarction in a murine model of ischemic stroke.[1][1] Platelet aggregation at sites of vascular injury is essential for normal hemostasis but also causes ...
Bernhard Nieswandt, Guido Stoll
openaire   +3 more sources

Comparison of Von Willebrand factor (VWF) activity VWF:Ac with VWF ristocetin cofactor activity VWF:RCo

Thrombosis Research, 2014
Ristocetin cofactor activity of Von Willebrand factor (VWF:RCo) and the ratio VWF:RCo to its antigen VWF:Ag are used as routine screening to estimate VWF function and to detect types of Von Willebrand disease (VWD) caused by loss of high molecular weight multimers. However, the VWF:RCo test is prone to analytic imprecisions due to various reasons.
Geisen, Ulrich   +6 more
openaire   +4 more sources

Evaluation of Monoclonal Antibodies to vWf Antigen for Use in Autoradiographing vWf Multimer Analysis

Thrombosis and Haemostasis, 1987
SummaryNine monoclonal antibodies (MAb, coded ESvWF 1-5, 7-10) to human von Willebrand’s factor (vWf) have been studied for their labelling characteristics with 125I and their ability to demonstrate vWf multimers by autoradiography after discontinuous SDS electrophoresis on agarose and agarose/acrylamide gels in plasma from normal and von Willebrand’s ...
M S Enayat   +4 more
openaire   +3 more sources

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