Results 91 to 100 of about 246,536 (223)

Data‐Driven Detection of Internal Erosion Initiation in Gap‐Graded Soils: Combining Particle‐Scale CFD‐DEM Simulation With 3D Convolutional Autoencoder

International Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.
ABSTRACT Internal erosion in gap‐graded soils poses significant risks to water‐retaining structures such as earth dams. However, its underlying mechanisms at the particle scale remain poorly understood. This study couples the discrete element method (DEM) with computational fluid dynamics (CFD) to simulate internal erosion in gap‐graded soil assemblies
Jie Qi, Negin Yousefpour, Guillermo A. Narsilio, Mehdi Pouragha   +3 more
wiley   +1 more source

The CFTR Corrector, VX-809 (Lumacaftor), Rescues ABCA4 Trafficking Mutants: a Potential Treatment for Stargardt Disease.

Cellular Physiology and Biochemistry, 2019
BACKGROUND/AIMS Mutations in ABCA4 cause Stargardt macular degeneration, which invariably ends in legal blindness. We studied two common mutants, A1038V (in NBD1) and G1961E (in NBD2), with the purpose of exploring how they interact with the cell's ...
Qiangni Liu, I. Sabirzhanova, E. Bergbower, M. Yanda, William G Guggino, L. Cebotaru   +5 more
semanticscholar   +1 more source

Interplay of trophic relaxation and directional selection shapes eco‐evolutionary responses to selective harvest in predator–prey systems

Oikos, EarlyView.
Fisheries‐induced evolution (FIE) describes the evolutionary changes in life‐history traits exhibited by target species in response to selective fishing pressures. Current studies predominantly focus on single‐species contexts, often assuming stationary natural selection and neglecting the impact of interacting species.
Yangke Shang, Minoru Kasada, Michio Kondoh   +2 more
wiley   +1 more source

Combination of ERK2 inhibitor VX-11e and voreloxin synergistically enhances anti-proliferative and pro-apoptotic effects in leukemia cells

Apoptosis, 2019
ERK1/2 inhibitors are new promising anticancer drugs. The aim of this study was to investigate the effect of the combination of ERK2 inhibitor VX-11e and voreloxin on MOLM-14, K562, REH and MOLT-4 leukemia cell lines.
E. Jasek-Gajda, H. Jurkowska, M. Jasińska, J. A. Litwin, G. Lis   +4 more
semanticscholar   +1 more source

Spectroscopic, X‐Ray Crystallographic, and Hirshfeld Surface Analyses for the Investigation of Intermolecular Interactions in Carboxamide Hydrazone Hybrids

ChemistryOpen, EarlyView.
Two novel carboxamide hydrazone hybrids are synthesized and characterized. Structural, spectroscopic, and computational analyses reveal dominant hydrogen bonding, π–π stacking, and reactive sites. Compound 2b exhibits potent antibacterial activity against Staphylococcus aureus, highlighting its potential as a cost‐effective therapeutic agent.
Nabila A. Kheder, Mostafa E. Salem, Saied M. Soliman, Ismail A. Elhaty, Naglaa S. Mahmoud, Mohamed Abdel‐Megid, Kamal M. Dawood   +6 more
wiley   +1 more source

Synergistic Continuous and Short Fiber Reinforcement in Additively Manufactured Poly(Ether Ether Ketone) Composites

Polymer Composites, EarlyView.
Synergistic Composite: Fabrication and Evaluation of Continuous and Chopped Fiber Reinforced PEEK Matrix. ABSTRACT Enhancing the mechanical properties of 3D‐printed thermoplastic composites has become a critical focus in advanced manufacturing, particularly for high‐performance materials like PEEK.
Altuğ Uşun, Hamdi Kuleyin, Recep Gümrük   +2 more
wiley   +1 more source

Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.

Chemical Research in Toxicology, 2018
Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human acetylcholinesterase (hAChE) was observed to be stereospecific.
S. Bester, M. Guelta, J. Cheung, M. Winemiller, Sue Y. Bae, J. Myslinski, S. Pegan, J. Height   +7 more
semanticscholar   +1 more source

MXene‐Supported Vanadium Sulfide Composites Reinforced by Tailored Carbon Nanotube Networks for High‐Performance Supercapattery

Small, EarlyView.
A rationally designed vanadium sulfide–MXene (VS–MX) hybrid composite reinforced with carbon nanotube (CNT) networks, for high‐performance supercapattery electrodes, is demonstrated. Structural analysis confirms uniform VS4 integration on MXene sheets, while CNT incorporation significantly boosts charge storage capacity.
Rahul S. Ingole, Snehal L. Kadam, Kwangjun Kim, Minwook Kim, Yong Tae Kim, Jun Seok Lee, Jong G. Ok   +6 more
wiley   +1 more source

HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001 [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

3D Bioprinted Engineered Living Microreactors for Continuous Organophosphorus Compound Degradation

Small Science, EarlyView.
3D bioprinted engineered living microreactors offer a novel solution for continuous organophosphorus compound (OPC) degradation. This work details the fabrication and characterization of porous microbial ELM bioreactors containing genetically engineered Escherichia coli for cyclic OPC detoxification.
Mark R. Shannon, Graham J. Day, Hermes Bloomfield‐Gadêlha, Valeska P. Ting, Adam W. Perriman   +4 more
wiley   +1 more source