Results 111 to 120 of about 243,296 (232)
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes
The FEBS Journal, EarlyView.During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb +4 more
wiley +1 more source
From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification. [PDF]
ChemphyschemThe development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Rodríguez-Dafonte P.
europepmc +2 more sources
Journal of Fish Biology, EarlyView.Abstract The migratory behaviour of Atlantic salmon kelts is poorly understood. Due to the Atlantic salmon's considerable socio‐economic and ecological importance, their precipitous population abundance declines, and the population resilience potential of salmon kelts, addressing these knowledge gaps is important.
Olivia Meredith Simmons +10 more
wiley +1 more source
New Phytologist, EarlyView.Summary Nonphotochemical quenching (NPQ) mechanisms fine‐tune light utilisation in the photosynthetic antenna, for example, in response to excess light, to prevent photodamage. NPQ comprises distinct mechanisms, all contributing to photoprotection but acting on different time scales.
Olga Blifernez‐Klassen +6 more
wiley +1 more source
New Phytologist, EarlyView.Summary Cellular ion and pH homeostasis are crucial factors affecting and regulating metabolic reactions, protein stability, signalling and transport mechanisms. To balance intracellular ion concentrations, organisms need to constantly sense and respond to both the extracellular environment and cell compartments' requests.
Anna Santin +15 more
wiley +1 more source
Functional divergence of LhcSR and PsbS in zeaxanthin‐mediated non‐photochemical quenching
New Phytologist, EarlyView.Summary To protect photosystem II from excess light, non‐photochemical quenching (NPQ) dissipates excess energy as heat. NPQ relies on trigger proteins, LhcSR in algae and PsbS in vascular plants, and the light‐regulated xanthophyll cycle, which interconverts violaxanthin and zeaxanthin through the opposite activities of violaxanthin de‐epoxidase and ...
Claudia Beraldo +8 more
wiley +1 more source
The response of rare CFTR mutations to specific modulator combinations
ERJ Open ResearchBackground The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) modulators elexacaftor (VX-445)–tezacaftor (VX-661)–ivacaftor (VX-770) (ETI) enables the effective rescue of CFTR function in people with the F508del mutation ...
Noemie Stanleigh +13 more
doaj +1 more source
Current Issues in Molecular BiologyCystic fibrosis (CF) is a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, a chloride and bicarbonate channel localized on the plasma membrane of epithelial cells.
Debora Baroni
doaj +1 more source