Results 111 to 120 of about 27,703 (234)

SlideSAVR: Enabling Live Analysis during Data Presentations via Multimodal Sketching and Voice Input

Computer Graphics Forum, EarlyView.
Abstract Interpersonal communication in data science can yield sought‐after insights, but presentation environments are often not conducive for live analysis, forcing the process to move offline. Through a formative survey with 16 participants, we identified both technical (e.g., complexity of tools) and psychological (e.g., pressure of programming ...
C. Han, M.M. Tanjim, S. Guo, C. Dierk, K.E. Isaacs, J. Hoffswell   +5 more
wiley   +1 more source

Parallel Vectors Extraction using Bézier Clipping

Computer Graphics Forum, EarlyView.
Abstract In this paper, we propose a novel local feature extraction algorithm for the parallel vectors (PV) operator. Our method is based on Bézier clipping, which is a bracketing‐based root finding method that is commonly‐used in computer‐aided geometric design.
Nico Daßler, Tobias Günther
wiley   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

Effect of Aurora kinase inhibitor (VX-680) on myeloma SP cells.

, 2013
(A). Cell cycle analysis of RPMI 8226 and AMO1 cells exposed toVX-680 (1 µM). X-axis, PI; Y-axis, cell count. RPMI 8226+DMSO: subG1 1.1%, G0/G1 47.3%, S 18.5%, G2/M 33.2%; RPMI 8226+VX-680 (1 uM): subG1 1.7%, G0/G1 3.4%, S 16.4%, G2/M 78.5%.
Atsushi Watanabe (64183), Kenichi Sawada (385075), Mitsugu Ito (385068), Kazuaki Teshima (385067), Masaaki Kume (385071), Naoto Takahashi (385073), Yoshiaki Hatano (385072), Hiroyuki Tagawa (385076), Keiko Iwamoto (385069), Miho Nara (385066), Atsushi Kitabayashi (385070), Shinsuke Iida (385074)   +11 more
core   +1 more source

Immunomodulatory Peptide LW‐9 Enhances Doxorubicin Efficacy by Downregulating PD‐L1 and Promoting Intratumoral T‐Cell Responses in Murine Breast Cancer

Immunology, EarlyView.
LW‐9, a peptide derived from Phoneutria nigriventer venom, enhances antitumor immunity in a murine breast cancer model by remodelling the tumour microenvironment. Treatment reduces PD‐L1 expression while increasing CD3+ and GITR+ T‐cell infiltration, resulting in delayed tumour progression, particularly when combined with doxorubicin.
Ingrid Mayara Cavalcante Trevisan, Cibele Pereira Mariano, Sabrina Carvalho Brunelli, Gabriel da Silva Cordeiro, Jessika Takaki, Valquiria Aparecida Matheus, Liana Verinaud, Catarina Rapôso   +7 more
wiley   +1 more source

Aggregate Market Power: Measurement, Drivers, and Macroeconomic Effects

Journal of Economic Surveys, EarlyView.
ABSTRACT This survey reviews the macroeconomic literature on market power, focusing on its measurement, determinants, and macroeconomic effects. It synthesizes evidence from concentration ratios, business dynamism indicators, and markup/markdown estimates, documenting a distinct change in trends since the 1980s, especially in the United States ...
Maria Alessandra Rossi
wiley   +1 more source

Catalytic Degradation of the Nerve Agent VX by Water-Swelled Polystyrene-Supported Ammonium Fluorides

, 2016
The catalytic degradation of the nerve agent VX (O-ethyl S-2-(diisopropylamino)ethyl methylphosphonothioate) by water-swelled polymer-supported ammonium fluorides is described. VX (0.06–0.53 mol/mol F–) is rapidly degraded (t1/2 ∼ 10–30 min) to form the “
Daniele Marciano (1600009), Yossi Zafrani (1600012), Michael Goldvaser (1600000), Ishay Columbus (1599994)   +3 more
core   +1 more source

Systemic RVX‐208 Attenuates Experimental Periodontitis Through Inflammatory Host Modulation

Journal of Periodontal Research, EarlyView.
Prophylactic systemic treatment with RVX‐208 mitigated alveolar bone loss in experimental periodontitis. In THP‐1 cells, transcriptomic analysis showed that RVX‐208 downregulated inflammatory gene expression associated with Pg, and it produced a more moderate and limited effect on global gene expression than the pan‐BET inhibitor JQ1.
Sheikh Alam, Simrah Ansari, Birtan T. Yilmaz, David J. Cohen, James Sugai, Caroline Carrico, Melissa Morgan, Matthew S. Halquist, Sinem Esra Sahingur, Barbara D. Boyan, Zvi Schwartz, William V. Giannobile, Zhao Lin   +12 more
wiley   +1 more source

Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines

, 2008
Anaplastic thyroid cancers (ATC) are aggressive tumors, which exhibit cell cycle misregulations leading to uncontrolled cellular proliferation and genomic instability.
F. S. Ambesi Impiombato, J. G. Delcros, Y. Arlot Bonnemains, ULISSE, SALVATORE, B. Martin, BALDINI, ENKE, D'ARMIENTO, Massimino, M. Toller, F. Curcio   +8 more
core   +2 more sources

VX-548 in the treatment of acute pain

Pain Management
Acute pain management requires balancing analgesia with adverse effects risk. The voltage-gated sodium channel NaV1.8 plays an important role in pain physiology, and its inhibition was shown to have analgesic effects. VX-548 is a new oral NaV1.8-specific inhibitor that received United States Food and Drug Administration Fast Track and Breakthrough ...
Aaron Yik Hang Kong, Hon Sen Tan, Ashraf S Habib   +2 more
openaire   +3 more sources