Results 121 to 130 of about 27,247 (245)

Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells

, 2018
Cystic fibrosis patients exhibit chronic Pseudomonas aeruginosa respiratory infections and sustained proinflammatory state favoring lung tissue damage and remodeling, ultimately leading to respiratory failure.
Brochiero, Emmanuelle, Emmanuelle Brochiero, Roussel, Lucie, Manon Ruffin, Émilie Maillé, Ruffin, Manon, Lucie Roussel, Maillé, Émilie, Rousseau, Simon, Simon Rousseau   +9 more
core   +1 more source

Aggregate Market Power: Measurement, Drivers, and Macroeconomic Effects

Journal of Economic Surveys, EarlyView.
ABSTRACT This survey reviews the macroeconomic literature on market power, focusing on its measurement, determinants, and macroeconomic effects. It synthesizes evidence from concentration ratios, business dynamism indicators, and markup/markdown estimates, documenting a distinct change in trends since the 1980s, especially in the United States ...
Maria Alessandra Rossi
wiley   +1 more source

Unraveling the Mechanism of Action, Binding Sites, and Therapeutic Advances of CFTR Modulators: A Narrative Review

Current Issues in Molecular Biology
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, a chloride and bicarbonate channel localized on the plasma membrane of epithelial cells.
Debora Baroni
doaj   +1 more source

Maximal Swimming Speed Explains Differences in Habitat Use Among Invasive Ponto‐Caspian Dikerogammarus Species (Crustacea, Amphipoda)

Journal of Zoology, EarlyView.
The three invasive Ponto‐Caspian Dikerogammarus species (D. bispinosus, D. haemobaphes, and D. villosus) show niche differentiation along the current velocity gradient. In the present study, we experimentally measured their maximal swimming speeds to test whether they coincide with their tolerances for currents.
Milán Kerekes, James W. E. Dickey, Ádám Egri, Péter Borza   +3 more
wiley   +1 more source

The response of rare CFTR mutations to specific modulator combinations

ERJ Open Research
Background The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) modulators elexacaftor (VX-445)–tezacaftor (VX-661)–ivacaftor (VX-770) (ETI) enables the effective rescue of CFTR function in people with the F508del mutation ...
Noemie Stanleigh, Michal Gur, Michal Shteinberg, Aryeh Weiss, Naama Sebbag-Sznajder, Deborah Duran, Myriam Grunewald, Liron Birimberg-Schwartz, Lea Pevzner, Ronen Bar-Yoseph, Jeffrey M. Beekman, Eitan Kerem, Michael Wilschanski, Batsheva Kerem   +13 more
doaj   +1 more source

The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models

Photochemistry and Photobiology, EarlyView.
This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva, Rebeca Barros Nascimento, Giovanna Lopes Carvalho, Rebeca Boltes Cecatto, Maria Stella Moreira, Maria Fernanda Setúbal Destro Rodrigues   +5 more
wiley   +1 more source

CP7q increases the functional rescue of ΔF508-CFTR by VX-809 in A549 and FRT cells.

, 2016
(A) ΔF508-CFTR expressing A549 cells were incubated with 5 μM VX-809 in the presence and absence of 10 μM CP7q or 5 μM VX-770 for 48 hours. The traces are showing iodide influx via the rescued ΔF508-CFTR stimulated with 10 μM forskolin and 10 μM VX-770 ...
Jinhong Park (161037), Yohan Seo (773204), Sungwoo Jo (849568), Satish Kumar (37582), Pawan K. Sharma (805741), Ho K. Lee (773206), Dong-Kyu Jeon (849567), Poonam Khloya (849566), Wan Namkung (161030)   +8 more
core   +1 more source

Beyond biologic sex: Exploratory insights into the heterogeneity of hormonal and contextual drivers of periodontal and peri‐implant outcomes

Periodontology 2000, EarlyView.
Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole, Mark Gettas, Roberto Farina, Yvonne Hernandez‐Kapila   +3 more
wiley   +1 more source

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

A Machine Learning‐Based Model of Three‐Dimensional Ion Fluxes in the High‐Altitude Earth's Northern Cusp

Journal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 5, October 2026.
Abstract Magnetic reconnection at the dayside magnetopause is the primary pathway for transferring mass, momentum, and energy from the solar wind into the terrestrial magnetosphere. Previous studies have shown that the spatiotemporal dynamics of dayside magnetic reconnection can be inferred remotely from properties of Earth's cusps, specifically their ...
Gonzalo Cucho‐Padin, David Sibeck, Xueyi Wang, Daniel da Silva, Xiaolei Li, Gowtan Valluri, Cristian Ferradas, Hyunju Connor, Yu Lin   +8 more
wiley   +1 more source