Results 121 to 130 of about 27,703 (234)
The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models
Photochemistry and Photobiology, EarlyView.This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva +5 more
wiley +1 more source
Current Issues in Molecular BiologyCystic fibrosis (CF) is a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, a chloride and bicarbonate channel localized on the plasma membrane of epithelial cells.
Debora Baroni
doaj +1 more source
Favorable Pendant-Amino Metal Chelation in VX Nerve Agent Model Systems
, 2016 We have performed DFT computational studies [B3LYP, 6-31+G*] to obtain metal ion coordination isomers of VX-Me [MeP(O)(OMe)(SCH2CH2NMe2)], a model of two of the most lethal nerve agents: VX [MeP(O)(OEt)(SCH2CH2N(iPr)2)] and Russian-VX [MeP(O)(OCH2CHMe2)(
David G. Churchill (1856689) +3 more
core +1 more source
Periodontology 2000, EarlyView.Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole +3 more
wiley +1 more source
The response of rare CFTR mutations to specific modulator combinations
ERJ Open ResearchBackground The combination of the cystic fibrosis transmembrane conductance regulator (CFTR) modulators elexacaftor (VX-445)–tezacaftor (VX-661)–ivacaftor (VX-770) (ETI) enables the effective rescue of CFTR function in people with the F508del mutation ...
Noemie Stanleigh +13 more
doaj +1 more source
, 2017 This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete.
Australian Red Cross Society, National Office
core
TGF-beta downregulation of VX-809-corrected F508del CFTR in HAECs.
, 2014 F508del CFTR homozygous HAECs were grown at air-liquid interface culture for 6 weeks and treated with TGF-beta (10 ng/ml) and/or VX-809 (3 µM) for 48 h prior to Isc measurement.
Yan Sanders (636855) +9 more
core +1 more source
Comprehensive Physiology, Volume 16, Issue 6, December 2026.Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou +5 more
wiley +1 more source
Enabling Hybrid Modeling in Commercial MBS Software: A Force‐Level Approach
Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 4, December 2026.ABSTRACT Hybrid modeling aims to combine physical and data‐driven models to increase simulation accuracy without losing physical interpretability. In the context of dynamic mechanical systems, this enables the compensation of modeling inaccuracies that arise from simplifications, missing effects, or uncertain parameters. In this work, a hybrid model is
Meike Wohlleben +3 more
wiley +1 more source
VX-809 stabilizes the cell-surface pool of rΔF508 CFTR.
, 2015 (A) ΔF508 CFTR in CFBE41o-ΔF cells were rescued to cell surface by incubating at 27°C for 48 h followed by 3 h pretreatment with 3 μM VX-809. The cells were transferred to fresh medium containing cycloheximide (CHX) with or without VX-809 that is ...
Lianwu Fu (724853) +6 more
core +1 more source