Results 101 to 110 of about 27,703 (234)

Mass Spectrometry in Authentication and Forensic Approaches for Determining the Origin of Hazardous Chemicals

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi, Grégoire Delaporte, Christine Albaret, Emmanuel Joubert, Anne Bossée, Emilien L. Jamin, Laurent Debrauwer   +6 more
wiley   +1 more source

Analysis of Mechanical‐Electrical‐Hydraulic Coupled Vibration Response Characteristics of Thermal Control Circulating Pumps Supported by Water‐Lubricated Bearings

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT The operational reliability of thermal control circulation pumps is significantly restricted by the multi‐physics coupled environment. To reveal the vibration transmission mechanisms and dynamic response characteristics under multi‐field coupled excitations, a multi‐DOF coupled dynamic representation of the overall system, incorporating the ...
Jianfeng Luo, Liukai Hou, Yutao Zou, Kaiyuan Hao, Guangwu Zhou   +4 more
wiley   +1 more source

VX‐765 alleviates motor and cognitive impairments via inhibiting PANoptosis activation in the neonatal rats after hypoxic–ischemic brain damage

Pediatric Discovery
Neonatal hypoxia–ischemia (HI) is one of the main factors that cause neonatal severe neurologic impairment and death. Shown by a large number of studies, caspase‐1 plays a significant effect in diseases such as hypoxic–ischemic brain damage (HIBD) and ...
Xiaohuan Li, Mulan Chen, Boqing Xu, Yepeng Fan, Chunfang Dai, Zhifang Dong   +5 more
doaj   +1 more source

Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells

, 2018
Cystic fibrosis patients exhibit chronic Pseudomonas aeruginosa respiratory infections and sustained proinflammatory state favoring lung tissue damage and remodeling, ultimately leading to respiratory failure.
Brochiero, Emmanuelle, Emmanuelle Brochiero, Roussel, Lucie, Manon Ruffin, Émilie Maillé, Ruffin, Manon, Lucie Roussel, Maillé, Émilie, Rousseau, Simon, Simon Rousseau   +9 more
core   +1 more source

Cinnamic Acid Attenuates Ethanol‐Exacerbated Hepatocyte Pyroptosis in Type 2 Diabetes via AMPK‐Mediated NLRP3/GSDMD Inhibition

Phytotherapy Research, EarlyView.
CA directly binds to and activates AMPK to suppress NLRP3/GSDMD signaling, thereby alleviating hepatocyte pyroptosis in T2DM mice. ABSTRACT Type 2 diabetes mellitus (T2DM) is frequently accompanied by chronic ethanol (ET) consumption, which worsens metabolic dysregulation and organ damage.
Huaiying Tang, Qin Xiang, Yue Zhang, Yu Zhang, Xiangxiang Fu, Liming Tan, Yongli Zhang, Siqi Li, Dong Gong, Xu Guo, Yonghong Zhang, Li Chen, Tao Zheng, Qibin Wang   +13 more
wiley   +1 more source

Experimental assessment of column rectangularity in flat‐slab slab–column connections

Structural Concrete, EarlyView.
Abstract This paper presents an experimental investigation of the punching shear behavior of seven 3.00 m × 3.00 m × 0.20 m flat slabs without shear reinforcement, supported by internal rectangular columns. The column side lengths were varied to obtain aspect ratios, cmax/cmin, from 1.67 to 4.00, while the flexural reinforcement and overall slab ...
Liana de Lucca Jardim Borges, Ricardo de Paula Randi, Marília Gonçalves Marques, Elyson Andrew Pozo Liberati, Leandro Mouta Trautwein, Guilherme Sales Melo   +5 more
wiley   +1 more source

Pengembangan Software Game Menggunakan Rpg Maker Vx

, 2010
Dalam Tugas Akhir ini dibahas mengenai perancangan game Role Playing Game (RPG) menggunakan RPG Maker VX. Software RPG Maker VX ini digunakan untuk mempermudah dalam pembuatan perangkat lunak game atau software game.
Beny
core  

Profiling the Response of Rare Cystic Fibrosis Variants to VX-121

To compare the variant-specific effects of VX-121 to those of other current correctors, we employed DMS to survey its effects on the plasma membrane expression of 232 CF variants.
JHANGIANI, ASHISH R.
core   +1 more source

CP7q increases the functional rescue of ΔF508-CFTR by VX-809 in A549 and FRT cells.

, 2016
(A) ΔF508-CFTR expressing A549 cells were incubated with 5 μM VX-809 in the presence and absence of 10 μM CP7q or 5 μM VX-770 for 48 hours. The traces are showing iodide influx via the rescued ΔF508-CFTR stimulated with 10 μM forskolin and 10 μM VX-770 ...
Jinhong Park (161037), Yohan Seo (773204), Sungwoo Jo (849568), Satish Kumar (37582), Pawan K. Sharma (805741), Ho K. Lee (773206), Dong-Kyu Jeon (849567), Poonam Khloya (849566), Wan Namkung (161030)   +8 more
core   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source