Results 101 to 110 of about 27,247 (245)

Sparse Graphs With Local Covering Conditions on Edges

Journal of Graph Theory, EarlyView.
ABSTRACT In 1988, Erdős suggested the question of minimizing the number of edges in a connected n $n$‐vertex graph where every edge is contained in a triangle. Shortly after, Catlin, Grossman, Hobbs, and Lai resolved this in a stronger form. In this paper, we study a natural generalization of the question of Erdős in which we replace “triangle” with ...
Debsoumya Chakraborti, Amirali Madani, Anil Maheshwari, Babak Miraftab   +3 more
wiley   +1 more source

Good Real Perturbations of Simple Corank One Map Germs From R3$\mathbb {R}^3$ to R3$\mathbb {R}^3$

Mathematische Nachrichten, EarlyView.
ABSTRACT The existence of good real perturbations of map germs is one of the most interesting open questions in singularity theory. In this paper, we investigate this question for all simple corank one map germs from R3$\mathbb {R}^3$ to R3$\mathbb {R}^3$, we give a complete description of those that admit a good real perturbation.
A. J. Miranda, M. J. Saia, T. O. Souza
wiley   +1 more source

VX‐765 alleviates motor and cognitive impairments via inhibiting PANoptosis activation in the neonatal rats after hypoxic–ischemic brain damage

Pediatric Discovery
Neonatal hypoxia–ischemia (HI) is one of the main factors that cause neonatal severe neurologic impairment and death. Shown by a large number of studies, caspase‐1 plays a significant effect in diseases such as hypoxic–ischemic brain damage (HIBD) and ...
Xiaohuan Li, Mulan Chen, Boqing Xu, Yepeng Fan, Chunfang Dai, Zhifang Dong   +5 more
doaj   +1 more source

State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548

Molecular Pharmacology
Nav1.8 sodium channels (Nav1.8) are an attractive therapeutic target for pain because they are prominent in primary pain-sensing neurons with little expression in most other kinds of neurons. Recently, two Nav1.8-targeted compounds, VX-150 and VX-548, have shown efficacy in clinical trials for reducing pain.
Patric Vaelli, Akie Fujita, Sooyeon Jo, Han-Xiong Bear Zhang, Tomás Osorno, Xiao Ma, Bruce P. Bean   +6 more
openaire   +2 more sources

Mass Spectrometry in Authentication and Forensic Approaches for Determining the Origin of Hazardous Chemicals

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi, Grégoire Delaporte, Christine Albaret, Emmanuel Joubert, Anne Bossée, Emilien L. Jamin, Laurent Debrauwer   +6 more
wiley   +1 more source

TGF-beta downregulation of VX-809-corrected F508del CFTR in HAECs.

, 2014
F508del CFTR homozygous HAECs were grown at air-liquid interface culture for 6 weeks and treated with TGF-beta (10 ng/ml) and/or VX-809 (3 µM) for 48 h prior to Isc measurement.
Yan Sanders (636855), Anusha Sridharan (634793), Alicia J. Ostmann (456924), Amir Rezayat (456925), Stephanie Kortyka (636853), William T. Harris (444214), Hongtao Sun (456928), Anjaparavanda P. Naren (583409), John P. Clancy (438294), Kavitha Kotha (636854)   +9 more
core   +1 more source

Analysis of Mechanical‐Electrical‐Hydraulic Coupled Vibration Response Characteristics of Thermal Control Circulating Pumps Supported by Water‐Lubricated Bearings

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT The operational reliability of thermal control circulation pumps is significantly restricted by the multi‐physics coupled environment. To reveal the vibration transmission mechanisms and dynamic response characteristics under multi‐field coupled excitations, a multi‐DOF coupled dynamic representation of the overall system, incorporating the ...
Jianfeng Luo, Liukai Hou, Yutao Zou, Kaiyuan Hao, Guangwu Zhou   +4 more
wiley   +1 more source

Shortcourse RPG Maker VX Ace

, 2014
RPG Maker VX Ace merupakan solusi mudah bagi para pemula yang ingin belajar membuat game. RPG Maker VX Ace adalah sebuah software yang dapat digunakan untuk membuat game.
Ignas (ed.)
core  

Experimental assessment of column rectangularity in flat‐slab slab–column connections

Structural Concrete, EarlyView.
Abstract This paper presents an experimental investigation of the punching shear behavior of seven 3.00 m × 3.00 m × 0.20 m flat slabs without shear reinforcement, supported by internal rectangular columns. The column side lengths were varied to obtain aspect ratios, cmax/cmin, from 1.67 to 4.00, while the flexural reinforcement and overall slab ...
Liana de Lucca Jardim Borges, Ricardo de Paula Randi, Marília Gonçalves Marques, Elyson Andrew Pozo Liberati, Leandro Mouta Trautwein, Guilherme Sales Melo   +5 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source