Results 91 to 100 of about 24,286 (193)

Potentiation of BKCa channels by cystic fibrosis transmembrane conductance regulator correctors VX-445 and VX-121

Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel, ultimately leading to diminished transepithelial anion secretion and mucociliary clearance.
Robert J. Bridges, Michael B. Butterworth, Daniel C. Devor, Aaron Kolski-Andreaco, Stefanie Taiclet, John Sembrat, Zachary P. Wills, Michael M. Myerburg, Adam C. Straub   +8 more
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VX penetration following percutaneous poisoning: a dermal microdialysis study in the guinea pig

, 2008
VX, a potent organophosphorus compound, acts primarily by irreversibly inhibiting acetylcholinesterase resulting in an accumulation of acetylcholine, which produces the characteristic signs of nerve agent poisoning.
Wetherell, Janet R., Clough, Geraldine F., Read, Robert W., Armstrong, Stuart J.   +3 more
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High Pressure Densification Investigation of Li3PS4 and Li6PS5Cl Solid Electrolytes using Combine X‐Ray Diffraction, X‐Ray Absorption Tomography and Ionic Measurement

Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.
We used multiple analytical techniques at the Psiché beamline, Synchrotron Soleil, and at D20 instrument in Institut Laue Langevin, to study the densification of thiophosphate solid electrolytes Li3PS4 and Li6PS5Cl. Our combined X‐ray diffraction, absorption tomography, absorption density, neutron power diffraction, and ionic conductivity analyses ...
Oskar Thompson, Ove Korjus, Adrien Fauchier‐Magnan, Clément Albin, Sergio F. Mayer, Emmanuelle Suard, Thomas Hansen, Laura Henry, Nicolas Guignot, Vittoria Pischedda, Sylvie Le Floch, Claire Villevieille   +11 more
wiley   +1 more source

Physical Implementation of Optical Material‐Based Neural Networks Processing Enabled by Long‐Persistent Luminescence

Advanced Science, Volume 13, Issue 31, 4 June 2026.
This study reports on the physical implementation of optical material‐based neural processing using long‐persistent luminescence as memory‐retention and nonlinear optical material. The system performs optical‐domain preprocessing with opto‐electronic interfaces for stimulus delivery and readout, enabling real‐time demonstrations including Pong gameplay
Sangwon Wi, Yunsang Lee
wiley   +1 more source

Work Versus Force: Simultaneous Processes for Describing Interactions

Advanced Physics Research, Volume 5, Issue 6, June 2026.
ABSTRACT Achieving a unified description of interactions remains an open challenge in theoretical physics, which currently describes four fundamental forces. This situation may be viewed differently when interactions are formulated in terms of processes (work as actio) rather than forces (force as actio), not only at the macroscopic level but also at ...
Grit Kalies, Duong D. Do, Cornelia Breitkopf   +2 more
wiley   +1 more source

Integrative Drug‐Target Causal Analysis, Single‐Cell Sequencing and In‐Vivo Validation for Dissecting Molecular Mechanisms Underlying Focal Epilepsy

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Through Mendelian randomization analysis of the quantitative trait locus data, we identified that four drug targets, namely CASP1, FST, IL10RA, and SUCNR1, have significant genetic associations with the risk of focal epilepsy. This analysis provides preliminary genetic evidence for the causal mechanism by which these targets are involved in the onset ...
Huaiyu Sun, Xuewei Li, Weixuan Zhao, Hongmei Meng, Wuqiong Zhang   +4 more
wiley   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

NPF2 is involved in intracellular pH regulation and ion balance in the diatom Phaeodactylum tricornutum

New Phytologist, Volume 250, Issue 6, Page 3885-3899, June 2026.
Summary Cellular ion and pH homeostasis are crucial factors affecting and regulating metabolic reactions, protein stability, signalling and transport mechanisms. To balance intracellular ion concentrations, organisms need to constantly sense and respond to both the extracellular environment and cell compartments' requests.
Anna Santin, Monia Teresa Russo, Dany Croteau, Antonella Ruggiero, Sara Russo Spena, Laura Morales de los Rios, Claire Corratge‐Faillie, Seleem Brignone, Benoit Lacombe, Remo Sanges, Maurizio Chiurazzi, Maurizio Ribera d'Alcalà, Benjamin Bailleul, Angela Falciatore, Maria Immacolata Ferrante, Alessandra Rogato   +15 more
wiley   +1 more source

Functional divergence of LhcSR and PsbS in zeaxanthin‐mediated non‐photochemical quenching

New Phytologist, Volume 250, Issue 5, Page 3042-3052, June 2026.
Summary To protect photosystem II from excess light, non‐photochemical quenching (NPQ) dissipates excess energy as heat. NPQ relies on trigger proteins, LhcSR in algae and PsbS in vascular plants, and the light‐regulated xanthophyll cycle, which interconverts violaxanthin and zeaxanthin through the opposite activities of violaxanthin de‐epoxidase and ...
Claudia Beraldo, Cleo Bagchus, Dana Verhoeven, Alessandra Bellan, Caterina Gerotto, Emilie Wientjes, Herbert van Amerongen, Tomas Morosinotto, Alessandro Alboresi   +8 more
wiley   +1 more source

Kumpulan Top Minigame dan Event RPG Maker VX Ace

, 2015
Minigame atau quest merupakan permainan pelengkap dalam game khususnya RPG (Role Playing Game). Minigame dapat berhubungan dengan cerita dalam game atau tidak. Kehadiran minigame dalam sebuah RPG memberikan tantangan tambahan.
Wahana Komputer
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