Results 71 to 80 of about 24,286 (193)
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
PA14 reduced VX-809 (3 μM, 48 hours.) stimulated Cl secretion by CFBE cells.
, 2015 Neither Staphylococcus newman (Staph) nor Streptococcus salivari (Strep) reduced VX-809-stimulated F508del-CFTR Cl secretion compared to VX-809 alone ...
Bruce A. Stanton (226728) +3 more
core +1 more source
Unraveling the active site cover of coproheme decarboxylase from Listeria monocytogenes
The FEBS Journal, EarlyView.During heme biosynthesis in Gram‐positive bacteria, coproheme decarboxylase (ChdC) catalyzes the conversion of four‐propionate substrate coproheme to the two propionate product heme b. Its active site is universally covered by a flexible linking loop. This study identifies an important histidine residue, which stabilizes the loop in a ChdC homolog.
Nikolaus Falb +4 more
wiley +1 more source
Journal of Fish Biology, EarlyView.Abstract The migratory behaviour of Atlantic salmon kelts is poorly understood. Due to the Atlantic salmon's considerable socio‐economic and ecological importance, their precipitous population abundance declines, and the population resilience potential of salmon kelts, addressing these knowledge gaps is important.
Olivia Meredith Simmons +10 more
wiley +1 more source
Yue Han,* Jingyi Wang,* Jin Zhang,* Xi Zheng, Yijia Jiang, Wei Liu, Wenxiong Li Department of Surgical Intensive Care Unit, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors ...
Jiang Y +6 more
core
VX-548 in the treatment of acute pain
Pain ManagementAcute pain management requires balancing analgesia with adverse effects risk. The voltage-gated sodium channel NaV1.8 plays an important role in pain physiology, and its inhibition was shown to have analgesic effects. VX-548 is a new oral NaV1.8-specific inhibitor that received United States Food and Drug Administration Fast Track and Breakthrough ...
Aaron Yik Hang Kong +2 more
openaire +3 more sources
Vestigial Plastids in Parasitic Plants: Evolutionary Remnants or Adaptive Innovations?
Plant, Cell &Environment, EarlyView.ABSTRACT Throughout the evolutionary history of plants, chloroplasts originating from a cyanobacterial endosymbiosis have undergone remarkable adaptation and specialization, giving rise to a multitude of plastid types. The evolution toward parasitism in plants represents a particularly extreme case of such specialization.
Laia Jené, Sergi Munné‐Bosch
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Rising nighttime temperature (Tnight) can reduce crop yields while low Tnight may restrict plant growth and development. Despite quantifiable effects of Tnight, genetic basis underlying plant responses to Tnight remains unclear. We investigated natural variation in long‐term response of effective photosynthetic efficiency (Fq’/Fm’) to Tnight ...
Ana Carolina dos Santos Sá +5 more
wiley +1 more source
, 2017 This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete.
Australian Red Cross Society, National Office
core
CP7q increases the functional rescue of ΔF508-CFTR by VX-809 in A549 and FRT cells.
, 2016 (A) ΔF508-CFTR expressing A549 cells were incubated with 5 μM VX-809 in the presence and absence of 10 μM CP7q or 5 μM VX-770 for 48 hours. The traces are showing iodide influx via the rescued ΔF508-CFTR stimulated with 10 μM forskolin and 10 μM VX-770 ...
Jinhong Park (161037) +8 more
core +1 more source