Wallerian degeneration: the innate-immune response to traumatic nerve injury [PDF]
Journal of Neuroinflammation, 2011 Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by regeneration depends on the cellular and molecular events of Wallerian degeneration that injury induces distal to the lesion site, the domain through which severed
Rotshenker Shlomo
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The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves [PDF]
BMC Neuroscience, 2005 Background The progressive nature of Wallerian degeneration has long been controversial. Conflicting reports that distal stumps of injured axons degenerate anterogradely, retrogradely, or simultaneously are based on statistical observations at ...
Grumme Daniela S +6 more
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Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma [PDF]
Life Science Alliance, 2022 Neutrophils accumulate at the epineurium in Wallerian degeneration (WD) and inhibit macrophage infiltration from the epineurium into the parenchyma by releasing neutrophil extracellular traps, resulting in the delay of repair processes in WD.
Yasuhiro Yamamoto +10 more
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Wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction, case report, and review of literature [PDF]
Radiology Case ReportsWallerian degeneration (WD) is a process of axonal degradation that occurs downstream from a primary injury site and is often seen after strokes affecting the brainstem. This case report documents WD of the bilateral middle cerebellar peduncles (MCPs) in
Zaina Brinji +3 more
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MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling. [PDF]
PLoS ONE, 2013 Wallerian degeneration is delayed when sufficient levels of proteins with NMNAT activity are maintained within axons after injury. This has been proposed to form the basis of 'slow Wallerian degeneration' (Wld (S)), a neuroprotective phenotype conferred ...
Catherine Evans +3 more
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Wallerian degeneration: From mechanism to disease to imaging [PDF]
HeliyonWallerian degeneration (WD) was first discovered by Augustus Waller in 1850 in a transection of the glossopharyngeal and hypoglossal nerves in frogs. Initial studies suggested that the formation mechanism of WD is related to the nutrition of neuronal ...
Ruiqi Tian +4 more
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MicroRNA-301a knockout attenuates peripheral nerve regeneration by delaying Wallerian degeneration [PDF]
Neural Regeneration ResearchOur recent study demonstrated that knockout of microRNA-301a attenuates migration and phagocytosis in macrophages. Considering that macrophages and Schwann cells synergistically clear the debris of degraded axons and myelin during Wallerian degeneration,
Lanya Fu +19 more
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Role of Cell Oxidant Status and Redox State in Controlling Cell Proliferation and Apoptosis in Two Models of Wallerian Degeneration of Rat Sciatic Nerve [PDF]
AntioxidantsAfter peripheral nerve lesion, the role of reactive oxygen species (ROS) has not been clarified during Wallerian degeneration. The present study examined the participation of oxidant stress after rat sciatic nerve injury induced by two experimental ...
Myrna Alexandra Roberta Dent +2 more
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2018 DOI: 10.3969/j.issn.1672-6731.2018.03 ...
Tong HAN
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Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury [PDF]
Neural Regeneration ResearchMacrophages play an important role in peripheral nerve regeneration, but the specific mechanism of regeneration is still unclear. Our preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral ...
Yuhui Kou +5 more
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