Results 41 to 50 of about 346,229 (227)

Axon death signalling in Wallerian degeneration among species and in disease

Open Biology, 2019
Axon loss is a shared feature of nervous systems being challenged in neurological disease, by chemotherapy or mechanical force. Axons take up the vast majority of the neuronal volume, thus numerous axonal intrinsic and glial extrinsic support mechanisms ...
Arnau Llobet Rosell, L. Neukomm
semanticscholar   +1 more source

Wallerian degeneration: the innate-immune response to traumatic nerve injury

Journal of Neuroinflammation, 2011
Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by regeneration depends on the cellular and molecular events of Wallerian degeneration that injury induces distal to the lesion site, the domain through which severed
Rotshenker Shlomo
doaj   +1 more source

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]

, 2012
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C., DiAntonio, Aaron, Ebstein, Sarah Y, Gerdts, Josiah, Milbrandt, Jeffrey, Naylor, Sarah A, Royse, Emily X, Sasaki, Yo   +7 more
core   +2 more sources

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. [PDF]

PLoS Biology, 2006
Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wld(s)) mice overexpress a chimeric protein containing the NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase 1) and ...
R Grace Zhai, Yu Cao, P Robin Hiesinger, Yi Zhou, Sunil Q Mehta, Karen L Schulze, Patrik Verstreken, Hugo J Bellen   +7 more
doaj   +1 more source

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

Cell Reports, 2017
Studies with the WldS mutant mouse have shown that axon and synapse pathology in several models of neurodegenerative diseases are mechanistically related to injury-induced axon degeneration (Wallerian degeneration).
Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman   +2 more
doaj   +1 more source

Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure

Frontiers in Cellular Neuroscience, 2023
IntroductionThe degeneration of injured axons is driven by conserved molecules, including the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK, and regulators of these proteins.
Thomas J. Waller, Catherine A. Collins, Catherine A. Collins   +2 more
doaj   +1 more source

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Acta Neuropathologica Communications, 2019
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD).
Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan   +14 more
doaj   +1 more source

MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.

PLoS ONE, 2013
Wallerian degeneration is delayed when sufficient levels of proteins with NMNAT activity are maintained within axons after injury. This has been proposed to form the basis of 'slow Wallerian degeneration' (Wld (S)), a neuroprotective phenotype conferred ...
Catherine Evans, Simon J Cook, Michael P Coleman, Jonathan Gilley   +3 more
doaj   +1 more source

New zebrafish models of neurodegeneration [PDF]

, 2015
In modern biomedicine, the increasing need to develop experimental models to further our understanding of disease conditions and delineate innovative treatments has found in the zebrafish (Danio rerio) an experimental model, and indeed a valuable asset ...
A Nasevicius, A Vaccaro, AE Schaffer, AJ Rennekamp, AM Stewart, B Schmid, Claire Russell, DI Shah, EM Caramillo, F Ivanes, F Mahmood, HQ Jiang, JB Phillips, JW Mink, K Wager, K Wager, KC Donnell, KL Cerveny, L Wang, M Bond, M Nguyen, Michelangelo Campanella, MK Lin, PR Kasher, Rebeca Martín-Jiménez, S Ajroud-Driss, TO Auer, VT Cunliffe, Y Namavar   +28 more
core   +2 more sources

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration

Journal of Neuroscience, 2017
Wallerian degeneration (WD) is considered an essential preparatory stage to the process of axonal regeneration. In the peripheral nervous system, infiltrating monocyte-derived macrophages, which use the chemokine receptor CCR2 to gain entry to injured ...
J. Lindborg, M. Mack, R. Zigmond
semanticscholar   +1 more source