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Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves
Wallerian degeneration occurs immediately following injury to mammal peripheral nerves. To better understand the molecular events occurring during Wallerian degeneration, a rat model of sciatic nerve transection was used to assess differentially ...
Sheng Yi, Xin Tang, Jun Yu
exaly +2 more sources
Nerve injury is a common and difficult clinical problem worldwide with a high disability rate. Different from the central nervous system, the peripheral nervous system is able to regenerate after injury.
Jun Yu, Xiaosong Gu, Sheng Yi
doaj +2 more sources
MicroRNA-301a knockout attenuates peripheral nerve regeneration by delaying Wallerian degeneration [PDF]
Our recent study demonstrated that knockout of microRNA-301a attenuates migration and phagocytosis in macrophages. Considering that macrophages and Schwann cells synergistically clear the debris of degraded axons and myelin during Wallerian degeneration,
Lanya Fu +19 more
doaj +2 more sources
Role of Cell Oxidant Status and Redox State in Controlling Cell Proliferation and Apoptosis in Two Models of Wallerian Degeneration of Rat Sciatic Nerve [PDF]
After peripheral nerve lesion, the role of reactive oxygen species (ROS) has not been clarified during Wallerian degeneration. The present study examined the participation of oxidant stress after rat sciatic nerve injury induced by two experimental ...
Myrna Alexandra Roberta Dent +2 more
doaj +2 more sources
Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury [PDF]
Macrophages play an important role in peripheral nerve regeneration, but the specific mechanism of regeneration is still unclear. Our preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral ...
Yuhui Kou +5 more
doaj +2 more sources
DOI: 10.3969/j.issn.1672-6731.2018.03 ...
Tong HAN
doaj +1 more source
Axon injury leads to rapid depletion of NAD-biosynthetic enzyme NMNAT2 and high levels of its substrate, NMN. We proposed a key role for NMN in Wallerian degeneration but downstream events and their relationship to other mediators remain unclear.
Andrea Loreto +3 more
doaj +2 more sources
Wallerian degeneration of the pyramidal tract [PDF]
Robert, Forbrig, Adrian, Danek
openaire +3 more sources
Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients [PDF]
Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM).
Alves, Carlos Eduardo +14 more
core +17 more sources

