Results 21 to 30 of about 176,284 (162)

Wallerian degeneration in central nervous system: dynamic associations between diffusion indices and their underlying pathology. [PDF]

PLoS ONE, 2012
BACKGROUND: Although diffusion tensor imaging has been used to monitor Wallerian degeneration, the exact relationship between the evolution of diffusion indices and its underlying pathology, especially in central nervous system, remains largely unknown ...
Wen Qin, Min Zhang, Yueshan Piao, Deyu Guo, Zixin Zhu, Xin Tian, Kuncheng Li, Chunshui Yu   +7 more
doaj   +1 more source

c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. [PDF]

, 2012
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy, Turmaine, Mark, Mirsky, Rhona, Quintes, Susanne, Wicher, GK, Wilton, Daniel K., Chabrol, Elodie, Latouche, Morwena, Chabrol, E, Banerjee, Ambily, Behrens, A, Mirsky, R, Woodhoo, Ashwin, Jenkins, B, Mitter, Richard, Quintes, S, Turmaine, M, Greensmith, L, Jessen, Kristján R., Wicher, Grzegorz K., Woodhoo, A, Mitter, R, Behrens, Axel, Raivich, Gennadij, Wicher, Grzegorz K.,, Latouche, M, Banerjee, Annbily, Arthur-Farraj, PJ, Wilton, DK, Banerjee, A, Rahman, Mary, Jessen, KR, Rahman, M, Arthur-Farraj, Peter J., Greensmith, Linda, Raivich, G   +35 more
core   +1 more source

Heme Oxygenase 1 in Schwann Cells Regulates Peripheral Nerve Degeneration Against Oxidative Stress

ASN Neuro, 2019
During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state of developmental promyelinating cells.
Muwoong Kim, Hyosun Kim, Dogyeong Kim, Dokyoung Kim, Youngbuhm Huh, Chan Park, Hyung-Joo Chung, Junyang Jung, Na Young Jeong   +8 more
doaj   +1 more source

Wallerian degeneration of bilateral cerebral peduncles after acute carbon monoxide poisoning

BMC Neurology, 2020
Background Cases of Wallerian degeneration of bilateral cerebral peduncles after acute carbon monoxide poisoning have not yet been reported. To date, most of the delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) lesions captured in ...
Sui-yi Xu, Chang-xin Li, Le-yi Li, Yu Song, Yi Sui   +4 more
doaj   +1 more source

Differential gene and protein expression between rat tibial nerve and common peroneal nerve during Wallerian degeneration

Neural Regeneration Research, 2019
Wallerian degeneration and nerve regeneration after injury are complex processes involving many genes, proteins and cytokines. After different peripheral nerve injuries the regeneration rate can differ.
Yao-Fa Lin, Zheng Xie, Jun Zhou, Gang Yin, Hao-Dong Lin   +4 more
doaj   +1 more source

Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]

, 2002
Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
George K. Tofaris, Kristjan R. Jessen, Rhona Mirsky, Jessen, KR, Patterson, PH, Tofaris, GK, Mirsky, R, Paul H. Patterson   +7 more
core   +1 more source

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

Cell Reports, 2017
Studies with the WldS mutant mouse have shown that axon and synapse pathology in several models of neurodegenerative diseases are mechanistically related to injury-induced axon degeneration (Wallerian degeneration).
Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman   +2 more
doaj   +1 more source

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. [PDF]

PLoS Biology, 2006
Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wld(s)) mice overexpress a chimeric protein containing the NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase 1) and ...
R Grace Zhai, Yu Cao, P Robin Hiesinger, Yi Zhou, Sunil Q Mehta, Karen L Schulze, Patrik Verstreken, Hugo J Bellen   +7 more
doaj   +1 more source

Tracing of Neuronal Connections in the Human Brain by Magnetic Resonance Imaging in vivo [PDF]

, 1990
Axon degeneration after disruption of fibre tracts in the mammalian nervous system is accompanied by myelin breakdown which leads to changes in its magnetic resonance properties.
Danek, Adrian, Bauer, W. M., Fries, Wolfgang   +2 more
core   +1 more source

Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure

Frontiers in Cellular Neuroscience, 2023
IntroductionThe degeneration of injured axons is driven by conserved molecules, including the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK, and regulators of these proteins.
Thomas J. Waller, Catherine A. Collins, Catherine A. Collins   +2 more
doaj   +1 more source