Results 31 to 40 of about 18,042 (202)

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Acta Neuropathologica Communications, 2019
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD).
Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan   +14 more
doaj   +1 more source

Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure

Frontiers in Cellular Neuroscience, 2023
IntroductionThe degeneration of injured axons is driven by conserved molecules, including the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK, and regulators of these proteins.
Thomas J. Waller, Catherine A. Collins, Catherine A. Collins   +2 more
doaj   +1 more source

MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signaling.

PLoS ONE, 2013
Wallerian degeneration is delayed when sufficient levels of proteins with NMNAT activity are maintained within axons after injury. This has been proposed to form the basis of 'slow Wallerian degeneration' (Wld (S)), a neuroprotective phenotype conferred ...
Catherine Evans, Simon J Cook, Michael P Coleman, Jonathan Gilley   +3 more
doaj   +1 more source

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]

, 2012
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C., DiAntonio, Aaron, Ebstein, Sarah Y, Gerdts, Josiah, Milbrandt, Jeffrey, Naylor, Sarah A, Royse, Emily X, Sasaki, Yo   +7 more
core   +2 more sources

Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis [PDF]

, 2020
The diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected ...
Burke, David, deCarvalho, Mamede, Grosskreutz, Julian, Kiernan, Matthew C, Leigh, P Nigel, Swash, Michael, Turner, Martin R   +6 more
core   +1 more source

Stronger prediction of motor recovery and outcome post-stroke by cortico-spinal tract integrity than functional connectivity [PDF]

, 2018
ObjectivesTo examine longitudinal changes in structural and functional connectivity post-stroke in patients with motor impairment, and define their importance for recovery and outcome at 12 months.MethodsFirst-time stroke patients (N = 31) were studied ...
Corbetta, Maurizio, Lin, Leanne Y, Metcalf, Nicholas V, Ramsey, Lenny, Rengachary, Jennifer, Shimony, Joshua S, Shulman, Gordon L   +6 more
core   +3 more sources

Critical signaling pathways during Wallerian degeneration of peripheral nerve

Neural Regeneration Research, 2017
Wallerian degeneration is a critical biological process that occurs in distal nerve stumps after nerve injury. To systematically investigate molecular changes underlying Wallerian degeneration, we used a rat sciatic nerve transection model to examine ...
Qiong Cheng, Ya-xian Wang, Jun Yu, Sheng Yi   +3 more
doaj   +1 more source

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo [PDF]

, 2010
Axon and synapse degeneration are common components of many neurodegenerative diseases, and their rescue is essential for effective neuroprotection.
Babetto, Elisabetta, Beirowski, Bogdan, Brown, Rosalind, Coleman, Michael P, Gilley, Jonathan, Janeckova, Lucie, Ribchester, Richard R, Thomson, Derek   +7 more
core   +2 more sources

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

Journal of Neuroinflammation, 2019
Background Recovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physical impact severed axons, determined
Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal, Shlomo Rotshenker   +5 more
doaj   +1 more source

The Gene for Slow Wallerian Degeneration (Wlds) Is Also Protective against Vincristine Neuropathy

Neurobiology of Disease, 2001
Neurological diseases are frequently associated with axonal degeneration, which leads to dysfunction though separation of neurons from their targets. The mechanisms of axonal degeneration are largely unknown and in many cases are independent of those ...
Min-Sheng Wang, Yue Wu, Deborah G. Culver, Jonathan D. Glass   +3 more
doaj   +1 more source