Results 31 to 40 of about 176,284 (162)

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Acta Neuropathologica Communications, 2019
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD).
Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan   +14 more
doaj   +1 more source

Wallerian degeneration: an emerging axon death pathway linking injury and disease. [PDF]

, 2019
Axon degeneration is a prominent early feature of most neurodegenerative disorders and can also be induced directly by nerve injury in a process known as Wallerian degeneration.

core   +6 more sources

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

Journal of Neuroinflammation, 2019
Background Recovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physical impact severed axons, determined
Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal, Shlomo Rotshenker   +5 more
doaj   +1 more source

The Gene for Slow Wallerian Degeneration (Wlds) Is Also Protective against Vincristine Neuropathy

Neurobiology of Disease, 2001
Neurological diseases are frequently associated with axonal degeneration, which leads to dysfunction though separation of neurons from their targets. The mechanisms of axonal degeneration are largely unknown and in many cases are independent of those ...
Min-Sheng Wang, Yue Wu, Deborah G. Culver, Jonathan D. Glass   +3 more
doaj   +1 more source

Different protein expression patterns in rat spinal nerves during Wallerian degeneration assessed using isobaric tags for relative and absolute quantitation proteomics profiling

Neural Regeneration Research, 2020
Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags ...
Shuai Wei, Xue-Zhen Liang, Qian Hu, Wei-Shan Wang, Wen-Jing Xu, Xiao-Qing Cheng, Jiang Peng, Quan-Yi Guo, Shu-Yun Liu, Wen Jiang, Xiao Ding, Gong-Hai Han, Ping Liu, Chen-Hui Shi, Yu Wang   +14 more
doaj   +1 more source

Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis [PDF]

, 2017
Background: Axonal damage and loss substantially contribute to the incremental accumulation of clinical disability in progressive multiple sclerosis. Here, we assessed the amount of Wallerian degeneration in brain tissue of multiple sclerosis patients in
Dallenga, Tobias, Brigitte Maruschak, Brueck, Wolfgang, Singh, Shailender, Siebert, Heike, Wolfgang Brück, Winkler, Anne, Stadelmann, Christine, Anne Winkler, Shailender Singh, Christine Stadelmann, Tobias Dallenga, Shanu Roemer, Heike Siebert, Roemer, Shanu, Maruschak, Brigitte   +15 more
core   +1 more source

Ingenuity pathway analysis of gene expression profiles in distal nerve stump following nerve injury: insights into Wallerian degeneration

Frontiers in Cellular Neuroscience, 2016
Nerve injury is a common and difficult clinical problem worldwide with a high disability rate. Different from the central nervous system, the peripheral nervous system is able to regenerate after injury.
Jun Yu, Xiaosong Gu, Sheng Yi
doaj   +1 more source

Hot Cross Bun Sign Following Bilateral Pontine Infarction: A Case Report [PDF]

Journal of Movement Disorders, 2013
The hot cross bun sign is characterized by cruciform T2 signal hyperintensity in the pons and has been reported to be a specific but not pathognomic for multiple system atrophy.
Sook Young Roh, Hyun-soon Jang, Yoon Hee Kim   +2 more
doaj   +1 more source

Cold Exposure to the Recurrent Laryngeal Nerve: A Porcine Continuous Intraoperative Neuromonitoring Model Study

Head &Neck, EarlyView.
ABSTRACT Background Tissue exposure to cold temperatures is common in clinical practice, yet the safety of exposing the recurrent laryngeal nerve (RLN) to cold remains unclear. This study evaluated temperature‐dependent effects of cold exposure on RLN function.
Tzu‐Yen Huang, Hsin‐Yi Tseng, Yi‐Chu Lin, Gregory W. Randolph, Marika Russell, Amr H. Abdelhamid Ahmed, I‐Cheng Lu, Chih‐Hung Lin, Cheng‐Hsun Chuang, Jia Joanna Wang, Leong‐Perng Chan, Feng‐Yu Chiang, Li‐Ren Yeh, Che‐Wei Wu   +13 more
wiley   +1 more source

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

Neurobiology of Disease, 2008
Axon loss in the CNS is characteristic of many neurodegenerative diseases but the mechanisms of axon degeneration are poorly understood. In particular, we know little of the inflammatory response triggered by CNS axon degeneration with comparison to that
Karine Palin, Colm Cunningham, Penny Forse, V. Hugh Perry, Nick Platt   +4 more
doaj   +1 more source