Results 31 to 40 of about 12,188 (198)

Wallerian Degeneration, Wld^S, and Nmnat [PDF]

, 2010
Traditionally, researchers have believed that axons are highly dependent on their cell bodies for long-term survival. However, recent studies point to the existence of axon-autonomous mechanism(s) that regulate rapid axon degeneration after axotomy ...
Michael P. Coleman, Marc R. Freeman
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Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. [PDF]

PLoS Biology, 2006
Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury. Wallerian degeneration slow (Wld(s)) mice overexpress a chimeric protein containing the NAD synthase NMNAT (nicotinamide mononucleotide adenylyltransferase 1) and ...
R Grace Zhai, Yu Cao, P Robin Hiesinger, Yi Zhou, Sunil Q Mehta, Karen L Schulze, Patrik Verstreken, Hugo J Bellen   +7 more
doaj   +1 more source

Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

Cell Reports, 2017
Studies with the WldS mutant mouse have shown that axon and synapse pathology in several models of neurodegenerative diseases are mechanistically related to injury-induced axon degeneration (Wallerian degeneration).
Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman   +2 more
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Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure

Frontiers in Cellular Neuroscience, 2023
IntroductionThe degeneration of injured axons is driven by conserved molecules, including the sterile armadillo TIR domain-containing protein SARM1, the cJun N-terminal kinase JNK, and regulators of these proteins.
Thomas J. Waller, Catherine A. Collins, Catherine A. Collins   +2 more
doaj   +1 more source

Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss

Acta Neuropathologica Communications, 2019
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition that primarily affects the motor system and shares many features with frontotemporal dementia (FTD).
Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan   +14 more
doaj   +1 more source

Unusual aspects of inflammation in the nervous system: Wallerian degeneration [PDF]

, 1996
Wallerian degeneration in the PNS is accompanied by the rapid recruitment of monocytes, but monocytes do not invade CNS fibre tracts undergoing Wallerian degeneration.
Perry, V. Hugh, Angélica Castaño, Bell, Michael D., Castaño, Angélica, Michael D. Bell, V. Hugh Perry   +5 more
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The role of TNF-alpha during Wallerian degeneration [PDF]

, 2000
The role of TNF-alpha in the course of Wallerian degeneration of the sciatic nerve was studied in control and TNF-alpha deficient mice. In control animals, the characteristic phenomena of Wallerian degeneration such as axon and myelin degeneration as ...
Michel, Uwe, Kollias, G., Sachse, T., Siebert, Heike, Liefner, M., Bruck, Wolfgang W.   +5 more
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Wallerian degeneration: an emerging axon death pathway linking injury and disease. [PDF]

, 2019
Axon degeneration is a prominent early feature of most neurodegenerative disorders and can also be induced directly by nerve injury in a process known as Wallerian degeneration.

core   +2 more sources

Case Report Bilateral Wallerian Degeneration of the Pontocerebellar Tracts [PDF]

, 2020
Wallerian degeneration is the process of progressive demyelination and disintegration of the distal axonal segment following the transection of the axon or damage to the neuron.
Aynur Turan, Baki Hekimoglu, Azad Hekimoglu, Ihsaniye Suer Dogan, Mehmet Fevzi Oztekin   +4 more
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Wallerian degeneration of pyramidal tract after paramedian pons infarct [PDF]

, 2010
The intention of this study was the prospective analysis of Wallerian degeneration of the pyramidal tract after paramedian pons infarction.Patients with paramedian pons infarct underwent MR imaging including diffusion tensor imaging at admission and got ...
Gräßel, David, Witte, Otto W., Fitzek, S., Werner A. Kaiser, Kaiser, W.A., David Gräβel, Matthias Kohl, Witte, O.W., Thomas M. Ringer, Ringer, T.M., Axer, Hubertus, Sabine Fitzek, Axer, H., Ringer, Thomas M., Fitzek, Clemens, Grässel, D., Fitzek, C., Kohl, M., Kohl, Matthias, Fitzek, Sabine, Otto W. Witte, Clemens Fitzek, Hubertus Axer, Kaiser, Werner A.   +23 more
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