Results 51 to 60 of about 18,042 (202)

Structural and Functional Imaging of Motor Outcomes in Twins With Perinatal Stroke: A Case Report

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Perinatal arterial ischemic stroke (AIS) affects 1 in 4000 live births. Dystonia, affecting ~20% of children following AIS, is characterized by involuntary muscle contractions and abnormal movements. Why some develop dystonia post AIS, while others do not, remains unclear.
Prisca Hsu, Trish Domi, Cecilia Jobst, Min Sheng, Amanda Robertson, Erum Syed, Pradeep Krishnan, Douglas Cheyne, Nomazulu Dlamini   +8 more
wiley   +1 more source

Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.

PLoS Biology, 2010
The molecular triggers for axon degeneration remain unknown. We identify endogenous Nmnat2 as a labile axon survival factor whose constant replenishment by anterograde axonal transport is a limiting factor for axon survival.
Jonathan Gilley, Michael P Coleman
doaj   +1 more source

Wallerian Degeneration of the Bilateral Middle Cerebella Peduncles Secondary to Unilateral Pontine Hemorrhage

Psychiatry and Clinical Psychopharmacology, 2021
The bilateral and symmetrical Wallerian degeneration (WD) of the middle cerebella peduncles (MCPs) is rarely reported in pontine hemorrhage. We described a patient with WD of bilateral MCPs secondary to a strip of unilateral and transversal pontine ...
Dawei Chen, Jin Shi
doaj   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

Time‐Continuous Prognostic Mapping of Bell's Palsy Using Yanagihara Scores and Electroneurography

The Laryngoscope, EarlyView.
This study developed a novel, time‐continuous prognostic mapping for Bell's palsy by integrating longitudinal Yanagihara scores and electroneurography in patients treated with high‐dose corticosteroids. By employing a Bayesian probabilistic approach, this model enables individualized recovery estimation at any clinical time point, overcoming the ...
Shogo N. Watanabe, Shumpei Hisamoto, Kazuo Yasuhara, Kenji Kondo, Hironobu Nishijima   +4 more
wiley   +1 more source

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons [PDF]

, 2014
Mitochondrial dysfunction is the underlying cause of many neurological disorders, including peripheral neuropathies. Mitochondria rely on a proton gradient to generate ATP and interfering with electron transport chain function can lead to the deleterious
DiAntonio, Aaron, Milbrandt, Jeffrey, Summers, Daniel W   +2 more
core   +2 more sources

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice [PDF]

, 2019
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated NADase.
DiAntonio, Aaron, Doan, Ryan A, Geisler, Stefanie, Huang, Shay X, Mao, Xianrong, Milbrandt, Jeffrey, Park, Jiwoong, Strickland, Amy, Summers, Daniel W   +8 more
core   +1 more source

Longitudinal assessment of white matter pathology in the injured mouse spinal cord through ultra-high field (16.4T) in vivo diffusion tensor imaging [PDF]

, 2013
This study examined the sensitivity of ultra-high field (16.4 T) diffusion tensor imaging (DTI; 70 mu m in-plane resolution, 1 mm slice thickness) to evaluate the spatiotemporal development of severe mid-thoracic contusive spinal cord injury (SCI) in ...
Brennan, Faith H., Cowin, Gary J., Kurniawan, Nyoman D., Ruitenberg, Marc J.   +3 more
core   +1 more source

Morphological patterns of fetal lateral ventricular border irregularities: descriptive study

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objectives Alterations in the lateral ventricular borders have been documented in the prenatal diagnosis of certain fetal brain conditions. This study aimed to describe and classify the morphological patterns of lateral ventricular border irregularities (LVBI) and to discuss possible etiologies.
E. Hadi, A. Sorotzkin, L. Haddad, E. Kassif, C. Hoffmann, S. Shrot, S. Shoob, A. Shariv, Y. Mizrachi, M. Levy, Z. Leibovitz, T. Lerman‐Sagie, L. Gindes   +12 more
wiley   +1 more source