Results 51 to 60 of about 346,229 (227)
Tracing of Neuronal Connections in the Human Brain by Magnetic Resonance Imaging in vivo [PDF]
, 1990 Axon degeneration after disruption of fibre tracts in the mammalian nervous system is accompanied by myelin breakdown which leads to changes in its magnetic resonance properties.
Bauer, W. M. +2 more
core +1 more source
Science Advances, 2019 The ESCRT complex protein Vps4 is rapidly depleted upon nerve injury, causing autophagic impediment and axonal degeneration. Injured axons undergo a controlled, self-destruction process, known as Wallerian degeneration.
Haiqiong Wang +9 more
semanticscholar +1 more source
The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1
Frontiers in Cellular Neuroscience, 2019 After damage, axons in the peripheral nervous system (PNS) regenerate and regrow following a process termed Wallerian degeneration, but the regenerative process is often incomplete and usually the system does not reach full recovery.
Marta Pellegatta, C. Taveggia
semanticscholar +1 more source
The Gene for Slow Wallerian Degeneration (Wlds) Is Also Protective against Vincristine Neuropathy
Neurobiology of Disease, 2001 Neurological diseases are frequently associated with axonal degeneration, which leads to dysfunction though separation of neurons from their targets. The mechanisms of axonal degeneration are largely unknown and in many cases are independent of those ...
Min-Sheng Wang +3 more
doaj +1 more source
Neural Regeneration Research, 2020 Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags ...
Shuai Wei +14 more
doaj +1 more source
Hot Cross Bun Sign Following Bilateral Pontine Infarction: A Case Report [PDF]
Journal of Movement Disorders, 2013 The hot cross bun sign is characterized by cruciform T2 signal hyperintensity in the pons and has been reported to be a specific but not pathognomic for multiple system atrophy.
Sook Young Roh +2 more
doaj +1 more source
Journal of Neuroinflammation, 2017 BackgroundAxonal damage and loss substantially contribute to the incremental accumulation of clinical disability in progressive multiple sclerosis. Here, we assessed the amount of Wallerian degeneration in brain tissue of multiple sclerosis patients in ...
Shailender Singh +7 more
semanticscholar +1 more source
Neurobiology of Disease, 2019 Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal and synaptic degeneration are early and critical elements of nearly all human neurodegenerative diseases and ...
Rachel A Kline +10 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Differential protection of neuromuscular sensory and motor axons and their endings in Wld(S) mutant mice [PDF]
, 2012 Orthograde Wallerian degeneration normally brings about fragmentation of peripheral nerve axons and their sensory or motor endings within 24-48 h in mice. However, neuronal expression of the chimaeric, Wld(S) gene mutation extends survival of functioning
Hartley, R. +4 more
core +1 more source