Results 51 to 60 of about 2,121 (136)

Department of Pathology, Thomas Jefferson University, Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. [PDF]

, 2007
BACKGROUND: Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To address this need, we characterized mammary tumor gene expression
Assefnia, Shahin, Backlund, Michael G, Bastein, Roy, Bernard, Philip S, Brown, Powel H, Chandrasekharan, Subhashini, Churchill, Gary A, Furth, Priscilla A, Glazer, Robert I, Green, Jeffrey E, Herschkowitz, Jason I, Hu, Zhiyuan, Jones, Laundette P, Khramtsov, Andrey I, Kopelovich, Levy, Mikaelian, Igor, Olopade, Olufunmilayo I, Palazzo, Juan P, Perou, Charles M, Quackenbush, John, Rasmussen, Karen E, Simin, Karl, Usary, Jerry, Van Dyke, Terry, Weigman, Victor J, Yin, Yuzhi   +25 more
core   +1 more source

Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense [PDF]

, 2013
Natural antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against a wide range of bacteria, fungi and viruses.
Maffia, Paulo Cesar, Martínez, Melina María Belén, Sanchez, Mercedes Leonor   +2 more
core   +1 more source

Dysregulated proteome and N‐glycoproteome in ALG1‐deficient fibroblasts

PROTEOMICS, Volume 24, Issue 15, August 2024.
Abstract Asparagine‐linked glycosylation 1 protein is a β‐1,4‐mannosyltransferase, is encoded by the ALG1 gene, which catalyzes the first step of mannosylation in N‐glycosylation. Pathogenic variants in ALG1 cause a rare autosomal recessive disorder termed as ALG1‐CDG.
Rohit Budhraja, Neha Joshi, Silvia Radenkovic, Tamas Kozicz, Eva Morava, Akhilesh Pandey   +5 more
wiley   +1 more source

Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]

, 2015
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi, Arne Holmgren, Chan PH, Chen EP, Chu FF, Daiber A, Elias S. J. Arnér, Geismann C, Hogan B, Jaarsma D, Jian-Hong Zhu, Jin R, Leitzmann C, Li JJ, Li JJ, Lu YP, Makino N, Miranda-Vizuete A, Mirochnitchenko O, Motoori S, Mulder DW, Ogata M, Oury TD, Papaioannou V, Radi R, Sandbach JM, Takahara S, Thimmulappa RK, Tome ME, Vogel U, Wang F, Wen JK, Wen-Hsing Cheng, Wispe JR, Woychik RP, Xin Gen Lei, Ye-Shih Ho, Yongping Bao, Yoshida T   +38 more
core   +1 more source

Alterations in sperm RNAs persist after alcohol cessation and correlate with epididymal mitochondrial dysfunction

Andrology, Volume 12, Issue 5, Page 1012-1023, July 2024.
Abstract Background Chronic preconception paternal alcohol use adversely modifies the sperm epigenome, inducing fetoplacental and craniofacial growth defects in the offspring of exposed males. A crucial outstanding question in the field of paternal epigenetic inheritance concerns the resilience of the male germline and its capacity to recover and ...
Alexis N. Roach, Sanat S. Bhadsavle, Samantha L. Higgins, Destani D. Derrico, Alison Basel, Kara N. Thomas, Michael C. Golding   +6 more
wiley   +1 more source

Comprehensive proteomic analysis of human cervical-vaginal fluid using colposcopy samples [PDF]

, 2009
Background Cervical-vaginal fluid (CVF) plays an important role in the prevention of gynecological infections, although little is known about the contribution of CVF proteins to the immunity of the lower female genital tract.
Tjalma Wiebren AA, Coen Edmond P, Van Raemdonck Geert AA, Zegels Geert, Van Ostade Xaveer WM   +4 more
core   +2 more sources

Single‐cell transcriptomics reveal metastatic CLDN4+ cancer cells underlying the recurrence of malignant pleural effusion in patients with advanced non‐small‐cell lung cancer

Clinical and Translational Medicine, Volume 14, Issue 4, April 2024.
Highlights High level of CLDN4+ cancer cells can mediate the recurrence of malignant pleural effusion in advanced NSCLC patients. CLDN4 may contribute to cancer cell proliferation and is regulated by transcription factor ELF3. MIF signaling and VEGFA signaling shaped the immunosuppressive microenvironment in pleural effusion, contributing to the ...
Xiaoshen Zhang, Xuanhe Wang, Yaokai Wen, Shen Chen, Caicun Zhou, Fengying Wu   +5 more
wiley   +1 more source

In-depth proteomic analysis of a mollusc shell: acid-soluble and acid-insoluble matrix of the limpet Lottia gigantea [PDF]

, 2012
Background Invertebrate biominerals are characterized by their extraordinary functionality and physical properties, such as strength, stiffness and toughness that by far exceed those of the pure mineral component of such composites. This is attributed to
Edsinger-Gonzales, Eric, Mann, Karlheinz, Mann, Matthias   +2 more
core   +4 more sources

Response of swine spleen to Streptococcus suis infection revealed by transcription analysis [PDF]

, 2010
Astract Background Streptococcus suis serotype 2 (SS2), a major swine pathogen and an emerging zoonotic agent, has greatly challenged global public health.
Ran Li, Anding Zhang, Bo Chen, Liu Teng, Ya Wang, Huanchun Chen, Meilin Jin   +6 more
core   +1 more source

The use of shotgun label‐free quantitative proteomic mass spectrometry to evaluate the inflammatory response in aqueous humor from horses with uveitis compared to ophthalmologically healthy horses

Veterinary Ophthalmology, Volume 27, Issue 1, Page 40-52, January 2024.
Abstract Objective The objective of this study was to use shotgun label‐free tandem mass spectrometry (LF‐MS/MS) to evaluate aqueous humor (AH) from horses with uveitis (UH) compared to ophthalmologically healthy horses (HH). Animals Studied Twelve horses diagnosed with uveitis based on ophthalmic examination and six ophthalmologically healthy horses ...
Hannah M. Terhaar, Michala de Linde Henriksen, Carolina Mehaffy, Ann Hess, Richard J. McMullen Jr   +4 more
wiley   +1 more source