Results 101 to 110 of about 678,174 (319)

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

Scientific Reports, 2018
Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood.
Farid Ahmad Siddiqui, Gopinath Prakasam, Shilpi Chattopadhyay, Asad Ur Rehman, Rayees Ahmad Padder, Mohammad Afaque Ansari, Rasha Irshad, Kailash Mangalhara, Rameshwar N. K. Bamezai, Mohammad Husain, Syed Mansoor Ali, Mohammad Askandar Iqbal   +11 more
doaj   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Modeling cancer metabolism on a genome scale [PDF]

, 2015
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton, Eyal Gottlieb, Eytan Ruppin, Keren Yizhak, Kiuru M, Li L, Lobo C, Som P, Vazquez‐Martin A   +8 more
core   +1 more source

Hydrophobic Deep Eutectic Solvent (DES) Design Enables Optimally Hydrated DES‐in‐Water Electrolytes for High‐Performance Bromine Redox‐Enhanced Energy Storage Systems

Advanced Functional Materials, EarlyView.
Faradaic charging with bromine redox chemistry shows promise for energy storage, yet its efficient use in aqueous electrolytes is hindered by water decomposition and polybromides' cross‐diffusion, leading to suboptimal cell performance. This study introduces a tetrabutylammonium bromide‐based hydrated deep eutectic electrolyte with optimized water ...
Tae Pyeong Eom, Gunwoo Lee, Young Hun Cho, Younjee Lim, Seung Joon Yoo   +4 more
wiley   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
core   +5 more sources

Electrochemical Impedance Imaging via the Distribution of Diffusion Times [PDF]

Phys. Rev. Lett. 120, 116001 (2018), 2017
We develop a mathematical framework to analyze electrochemical impedance spectra in terms of a distribution of diffusion times (DDT) for a parallel array of random finite-length Warburg (diffusion) or Gerischer (reaction-diffusion) circuit elements. A robust DDT inversion method is presented based on Complex Nonlinear Least Squares (CNLS) regression ...
arxiv   +1 more source

Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]

, 2019
Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio, Chichiarelli, Silvia, Eufemi, Margherita, Giamogante, Flavia, Gurtner, Aymone, Macone, Alberto, Magliocca, Fabio Massimo, Manganaro, Roberto, Maras, Bruno, Marrocco, Ilaria, Paglia, Giuliano, Patsilinakos, Alexandros, Perugia, Giacomo, Ragno, Rino, Rubini, Elisabetta   +14 more
core   +1 more source

Using Recycled Materials in a Novel Dual Binder System for Hard Carbon Anodes: Closing the Loop Toward Sustainable Li‐/Na‐ion Batteries

Advanced Functional Materials, EarlyView.
The study explores for the first time the use of polyvinyl butyral (PVB), particularly recycled PVB, as a sustainable binder for Li/Na‐based electrodes in the framework of the H2020 SUNRISE EU project. Findings revealed that electrodes bound with a sustainable PAA/PVB mixture demonstrated exceptional rate capability and high initial Coulombic ...
Hamideh Darjazi, Alessandro Piovano, Giuseppina Meligrana, Giuseppe A. Elia, Claudio Gerbaldi   +4 more
wiley   +1 more source

Laplacian Autoencoders for Learning Stochastic Representations [PDF]

arXiv, 2022
Established methods for unsupervised representation learning such as variational autoencoders produce none or poorly calibrated uncertainty estimates making it difficult to evaluate if learned representations are stable and reliable. In this work, we present a Bayesian autoencoder for unsupervised representation learning, which is trained using a novel
arxiv  

Postulates on electromagnetic activity in biological systems and cancer [PDF]

, 2013
A framework of postulates is formulated to define the existence, nature, and function of a coherent state far from thermodynamic equilibrium in biological systems as an essential condition for the existence of life. This state is excited and sustained by
Alberts, Albrecht-Buehler, Albrecht-Buehler, Amos, Amos, Baker, Beil, Bonnet, Chen, Damadian, Dehmelt, Del Giudice, Devlin, Fröhlich, Fröhlich, Fröhlich, Fröhlich, Fuchs, Guck, Hagan, Hameroff, Hölzel, Jan Pokorný, Jandová, Jandová, Jelínek, Jitka Kobilková, Jiří Pokorný, Kirson, Kwapień, Michelakis, Michor, Nakamura, Nakamura, Pavlides, Pelling, Penrose, Pohl, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Popp, Preparata, Priel, Sahu, Sahu, Seyfried, Toyokuni, Traill, Tuszyński, Tyner, Vedruccio, Wada, Wada, Warburg, Warburg, Yamada, Zheng   +69 more
core   +1 more source